(3S,5S,6R)-Navtemadlin (Synonyms: (3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232)

Cat. No.: HY-12296A Purity: 97.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC₅₀ of 0.6 nM. Navtemadlin binds to MDM2 with a K_d of 0.045 nM.

For research use only. We do not sell to patients.

(3S,5S,6R)-Navtemadlin Chemical Structure

CAS No. : 2459946-14-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 150	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 150	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 195	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 920	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (3S,5S,6R)-Navtemadlin:

Navtemadlin In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

568.55

Formula

C₂₈H₃₅Cl₂NO₅S

CAS No.

2459946-14-4

Appearance

Solid

Color

White to off-white

SMILES

CC(C)S(C[C@@H](N1[C@@H](C2=CC=C(C=C2)Cl)[C@H](C3=CC(Cl)=CC=C3)C[C@](C)(C1=O)CC(O)=O)C(C)C)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (175.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7589 mL	8.7943 mL	17.5886 mL
5 mM	0.3518 mL	1.7589 mL	3.5177 mL
10 mM	0.1759 mL	0.8794 mL	1.7589 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.01%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (258 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)

References

[1]. Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58. [Content Brief]

[2]. Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7589 mL	8.7943 mL	17.5886 mL	43.9715 mL
	5 mM	0.3518 mL	1.7589 mL	3.5177 mL	8.7943 mL
	10 mM	0.1759 mL	0.8794 mL	1.7589 mL	4.3972 mL
	15 mM	0.1173 mL	0.5863 mL	1.1726 mL	2.9314 mL
	20 mM	0.0879 mL	0.4397 mL	0.8794 mL	2.1986 mL
	25 mM	0.0704 mL	0.3518 mL	0.7035 mL	1.7589 mL
	30 mM	0.0586 mL	0.2931 mL	0.5863 mL	1.4657 mL
	40 mM	0.0440 mL	0.2199 mL	0.4397 mL	1.0993 mL
	50 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.8794 mL
	60 mM	0.0293 mL	0.1466 mL	0.2931 mL	0.7329 mL
	80 mM	0.0220 mL	0.1099 mL	0.2199 mL	0.5496 mL
	100 mM	0.0176 mL	0.0879 mL	0.1759 mL	0.4397 mL

(3S,5S,6R)-Navtemadlin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3S,5S,6R)-Navtemadlin2459946-14-4(3S,5S,6R)-AMG 232 (3S,5S,6R)-KRT-232OthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name			Lot #
Applicant Name *			Email Address *
Phone Number			Department *
Organization Name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

(3S,5S,6R)-Navtemadlin (Synonyms: (3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232)

Customer Review

Other Forms of (3S,5S,6R)-Navtemadlin:

(3S,5S,6R)-Navtemadlin Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(3S,5S,6R)-Navtemadlin Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

Request for HNMR Report