2459946-14-4
Chemical Structure
(3S,5S,6R)-Navtemadlin
Synonym(s): (3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232
- CAS No.: 2459946-14-4
- Formula:C28H35Cl2NO5S
- Molecular Weight:568.55
IUPAC Name: 2-((3S,5S,6R)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
InChIKey: DRLCSJFKKILATL-CBZDIVBHSA-N
SMILES: CC(C)S(C[C@@H](N1[C@@H](C2=CC=C(C=C2)Cl)[C@H](C3=CC(Cl)=CC=C3)C[C@](C)(C1=O)CC(O)=O)C(C)C)(=O)=O
Biological Activity: (3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(3S,5S,6R)-Navtemadlin | 99.60% | (3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM. | ||||||||||||||||||||
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References
- [1]. Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58. [Content Brief]
- [2]. Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41. [Content Brief]
