J-104118
J-104118 is a potent and orally active squalene synthase (SQS) inhibitor with an IC50 of 0.52 nM. J-104118 inhibits cholesterol synthesis in mice. J-104118 can be used for cholesterol-lowering research.
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- CAS No.: 172277-82-6
- 화학식: C28H26Cl2FNO5
- 분자량:546.41
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
0.52 nM
Compound: J-104118
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Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cells
Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cells
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10.1016/0960-894X(96)00033-9 |
Chemical Information
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CAS No. 172277-82-6
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분자량 546.41
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화학식 C28H26Cl2FNO5
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SMILES
O=C([C@H](CC(O)=O)CC(N[C@@H](C)[C@@H](CC1=CC=C(C(Cl)=C1)Cl)C2=CC=C(C(F)=C2)C3=CC=CC=C3)=O)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
J-104118 Related Classifications
HY-116595 Related Classifications
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