2. Metabolic Enzyme/Protease
  3. Farnesyl Transferase
  4. J-104118

J-104118 is a potent and orally active squalene synthase (SQS) inhibitor with an IC50 of 0.52 nM. J-104118 inhibits cholesterol synthesis in mice. J-104118 can be used for cholesterol-lowering research.

For research use only. We do not sell to patients.

J-104118

J-104118 Chemical Structure

CAS No. : 172277-82-6

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Description

J-104118 is a potent and orally active squalene synthase (SQS) inhibitor with an IC50 of 0.52 nM. J-104118 inhibits cholesterol synthesis in mice. J-104118 can be used for cholesterol-lowering research[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
0.52 nM
Compound: J-104118
Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cells
Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cells
10.1016/0960-894X(96)00033-9
Molecular Weight

546.41

Formula

C28H26Cl2FNO5
CAS No.
SMILES

O=C([C@H](CC(O)=O)CC(N[C@@H](C)[C@@H](CC1=CC=C(C(Cl)=C1)Cl)C2=CC=C(C(F)=C2)C3=CC=CC=C3)=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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J-104118 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

J-104118172277-82-6J104118J 104118Farnesyl TransferaseFtasecholesterol synthesisSQSmiceInhibitorinhibitorinhibit

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