1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. GSM-1

GSM-1 

Cat. No.: HY-119165
Handling Instructions

GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1).

For research use only. We do not sell to patients.

GSM-1 Chemical Structure

GSM-1 Chemical Structure

CAS No. : 884600-68-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1)[1][2].

In Vitro

GSM-1 increases the levels of Aβ38 produced from WT APP. GSM-1 potently loweres the levels of Aβ42 of WT APP and all the Phe mutants by ∼70–80%, even for the V44F mutant, which produced only extremely small amounts of Aβ42[1].
GSM-1 directly binds to the N-terminal fragment of PS1[2].

Molecular Weight

481.98

Formula

C₂₆H₃₁ClF₃NO₂

CAS No.

884600-68-4

SMILES

O=C(O)C[[email protected]]1C[[email protected]@H](C2=CC=C(C(F)(F)F)C=C2)N([[email protected]@H](C3=CC=C(Cl)C=C3)CCC(C)C)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GSM-1GSM1GSM 1γ-secretaseGamma secretaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GSM-1
Cat. No.:
HY-119165
Quantity:
MCE Japan Authorized Agent: