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  4. (6R)-ML753286

(6R)-ML753286 is an isomer of ML753286 (HY-116494). ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species.

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(6R)-ML753286 Chemical Structure

(6R)-ML753286 Chemical Structure

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1 mg USD 550 In-stock
5 mg USD 950 In-stock
10 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (6R)-ML753286:

(6R)-ML753286 Related Antibodies

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Description

(6R)-ML753286 is an isomer of ML753286 (HY-116494). ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species[1].

In Vitro

ML753286 has IC50 values of >30, 0.6, and 39.0 μM for the inhibition of P-gp-, BCRP-, and OATP mediated transport, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(6R)-ML753286 Related Antibodies
In Vivo

ML753286 (25- or 50-mg/kg (PO); 10 or 20 mg/kg (IV); 0.083-24 hours) appears to completely inhibit Bcrp functions in rats at 25 mg/kg PO or at 20 mg/kg IV. The tmax values in plasma were 1.4, 4.0, and 4.1 hours in Bcrp KO rats, WT rats pre-administered 25-mg/kg ML753286, and WT rats pre-administered 50-mg/kg ML753286, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

355.43

Formula

C20H25N3O3
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C2C(NC3=C2C[C@]4(N([C@@H]3CC(C)C)C([C@@H](NC4=O)C)=O)[H])=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (70.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8135 mL 14.0675 mL 28.1349 mL
5 mM 0.5627 mL 2.8135 mL 5.6270 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (253 KB) HNMR (117 KB) MS (193 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8135 mL 14.0675 mL 28.1349 mL 70.3373 mL
5 mM 0.5627 mL 2.8135 mL 5.6270 mL 14.0675 mL
10 mM 0.2813 mL 1.4067 mL 2.8135 mL 7.0337 mL
15 mM 0.1876 mL 0.9378 mL 1.8757 mL 4.6892 mL
20 mM 0.1407 mL 0.7034 mL 1.4067 mL 3.5169 mL
25 mM 0.1125 mL 0.5627 mL 1.1254 mL 2.8135 mL
30 mM 0.0938 mL 0.4689 mL 0.9378 mL 2.3446 mL
40 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.7584 mL
50 mM 0.0563 mL 0.2813 mL 0.5627 mL 1.4067 mL
60 mM 0.0469 mL 0.2345 mL 0.4689 mL 1.1723 mL
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(6R)-ML753286 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(6R)-ML753286OthersIsomerInhibitorinhibitorinhibit

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