2. Cell Cycle/DNA Damage TGF-beta/Smad Epigenetics Anti-infection Apoptosis Metabolic Enzyme/Protease
  3. Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
  4. Mitoxantrone

Mitoxantrone  (Synonyms: Mitozantrone; NSC 301739)

Cat. No.: HY-13502 Purity: 99.58%
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Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

For research use only. We do not sell to patients.

CAS No. : 65271-80-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 46 publication(s) in Google Scholar

Other Forms of Mitoxantrone:

Mitoxantrone Related Antibodies

Top Publications Citing Use of Products

46 Publications Citing Use of MCE Mitoxantrone

Cell Proliferation/Viability Assay
Apoptosis Analysis
IF
WB

    Mitoxantrone purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Nov;57(11):2559-2573.  [Abstract]

    The USP11 inhibitor Mitoxantrone (5-20 μM; 24 h) was treated to A549 (western blotting for EGFR) cells. The EGFR protein levels were assessed by western blotting using an anti-EGFR antibody.

    Mitoxantrone purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Aug 5;44(1):228.  [Abstract]

    U87-MG and U251 cells with stable CSRP2 overexpression (CSRP2) were treated with or without 0.5 µM Mitoxantrone (MTO) for indicated time periods and the cell proliferation was analyzed. Cells transfected with control vector (NC) were used as a negative control. Two-way ANOVA with Sidak’s post hoc test, n = 6 per group for U87-MG and U251.

    Mitoxantrone purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Aug 5;44(1):228.  [Abstract]

    U87-MG and U251 cells with stable CSRP2 overexpression were treated with 0.5 µM Mitoxantrone (MTO) for 48 h and cell apoptosis was measured by flow cytometry

    Mitoxantrone purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Jun;26(6):917-931.  [Abstract]

    HeLa cells were pre-treated with DMSO or Mitoxantrone (10 μM, 1 h) followed by Tg treatment (1 μM, 3 h).

    Mitoxantrone purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Jun;26(6):917-931.  [Abstract]

    HeLa cells were pre-treated with DMSO or Mitoxantrone (10 μM, 1 h) followed by Tg treatment (1 μM, 3 h).

    View All Topoisomerase Isoform Specific Products:

    View All Isoforms
    Topoisomerase Topo I Topo II DNA gyrase

    View All PKC Isoform Specific Products:

    View All Isoforms
    PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity[1][2][3][4]. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].

    IC50 & Target[1][2]

    PKC

    8.5 μM (IC50)

    Topoisomerase II

     

    Cellular Effect
    Cell Line Type Value Description References
    2008 IC50
    7.8 1
    Compound: Mitoxantrone
    Antiproliferative activity against human 2008 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    Antiproliferative activity against human 2008 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    		[PMID: 31465686]
    2008 IC50
    7.8 1
    Compound: Mitoxantrone
    Antiproliferative activity against human 2008 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    Antiproliferative activity against human 2008 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    		[PMID: 31465686]
    HL-60 IC50
    0.024 1
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
    		[PMID: 30485090]
    A2780 IC50
    0.00055 3
    Compound: Mitoxantrone
    Concentration required to inhibit A2780-cell growth by 50%
    Concentration required to inhibit A2780-cell growth by 50%
    		[PMID: 9703471]
    A2780 IC50
    5.5 3
    Compound: Mitoxantrone
    Compound was evaluated for cytotoxicity against A2780 cell lines.
    Compound was evaluated for cytotoxicity against A2780 cell lines.
    		10.1016/0960-894X(96)00130-8
    A2780 IC50
    0.00055 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
    Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
    		[PMID: 9371240]
    A549 IC50
    0.036 1
    Compound: Mitoxantrone
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 30485090]
    A-375 IC50
    111.5 1
    Compound: Mitoxantrone
    Cytotoxicity against human A375 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human A375 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    A549 GI50
    8.3 3
    Compound: Mitoxantrone
    Growth inhibition of human A549 cells by MTT assay
    Growth inhibition of human A549 cells by MTT assay
    		[PMID: 20153184]
    A549 IC50
    0.07 3
    Compound: Mitoxantrone
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
    		[PMID: 35931243]
    A549 IC50
    0.036 1
    Compound: Mitoxantrone
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 30485090]
    A549 IC50
    15.7 6
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 26599534]
    A549 IC50
    25.3 6
    Compound: Mito
    Cytotoxicity against Homo sapiens (human) A549 cells after 24 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) A549 cells after 24 hr by MTT assay
    		10.1007/s00044-012-0325-2
    A549 IC50
    25.3 6
    Compound: Mito
    Cytotoxicity against Homo sapiens (human) A549 cells after 24 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) A549 cells after 24 hr by MTT assay
    		10.1007/s00044-012-0325-2
    A549 IC50
    15.7 6
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 26599534]
    A549 IC50
    7.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    A-375 IC50
    111.5 1
    Compound: Mitoxantrone
    Cytotoxicity against human A375 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human A375 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    A549 IC50
    3 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    A549 IC50
    7.25 3
    Compound: Table S1, R142C2
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 30684866]
    A-375 IC50
    2.6 x 10-8 41
    Compound: Mitoxantrone
    Inhibitory activity against human tumor cell line A0375 melanoma.
    Inhibitory activity against human tumor cell line A0375 melanoma.
    		[PMID: 7853345]
    A549 IC50
    7.25 3
    Compound: Table S1, R142C2
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 30684866]
    A549 IC50
    7.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    A2780 IC50
    0.00055 3
    Compound: Mitoxantrone
    Concentration required to inhibit A2780-cell growth by 50%
    Concentration required to inhibit A2780-cell growth by 50%
    		[PMID: 9703471]
    A549 IC50
    7.83 3
    Compound: MX
    Cytotoxicity against human A549 cells after 72 hrs
    Cytotoxicity against human A549 cells after 72 hrs
    		[PMID: 21354791]
    A549 IC50
    7.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 21458279]
    A2780 IC50
    0.00055 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
    Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
    		[PMID: 9371240]
    A549 IC50
    7.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 21458279]
    A549 IC50
    7.83 3
    Compound: MX
    Cytotoxicity against human A549 cells after 72 hrs
    Cytotoxicity against human A549 cells after 72 hrs
    		[PMID: 21354791]
    A2780 IC50
    25.1 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780/DX(RI)
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780/DX(RI)
    		[PMID: 10479282]
    A549 IC50
    8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 19615900]
    A549 IC50
    8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 19615900]
    A549 IC50
    0.3 3
    Compound: Mitoxantrone
    In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis)
    In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis)
    		[PMID: 12036369]
    A2780 IC50
    5.5 3
    Compound: Mitoxantrone
    Compound was evaluated for cytotoxicity against A2780 cell lines.
    Compound was evaluated for cytotoxicity against A2780 cell lines.
    		10.1016/0960-894X(96)00130-8
    A549 GI50
    8.3 3
    Compound: Mitoxantrone
    Growth inhibition of human A549 cells by MTT assay
    Growth inhibition of human A549 cells by MTT assay
    		[PMID: 20153184]
    A2780 IC50
    6.11 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780
    		[PMID: 10479282]
    SGC-7901 IC50
    0.293 1
    Compound: Mitoxantrone
    Antiproliferative activity against human SGC7901 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human SGC7901 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 30485090]
    Bel-7402 IC50
    116.6 1
    Compound: Mitoxantrone
    Cytotoxicity against human Bel7402 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human Bel7402 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    A549 IC50
    0.3 3
    Compound: Mitoxantrone
    Inhibitory concentration of compound against proliferation of lung carcinoma A549 cell line
    Inhibitory concentration of compound against proliferation of lung carcinoma A549 cell line
    		[PMID: 12031316]
    A549 GI50
    8.3 3
    Compound: Mitoxantrone
    Growth inhibition of human A549 cells by MTT assay
    Growth inhibition of human A549 cells by MTT assay
    		[PMID: 20153184]
    C6 IC50
    10.9 6
    Compound: Mito
    Cytotoxicity against Rattus norvegicus (rat) C6 cells after 24 hr by MTT assay
    Cytotoxicity against Rattus norvegicus (rat) C6 cells after 24 hr by MTT assay
    		10.1007/s00044-012-0325-2
    A549 IC50
    0.036 1
    Compound: Mitoxantrone
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 30485090]
    HL-60 GI50
    0.33 1
    Compound: MX, mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 17962028]
    C6 IC50
    11 6
    Compound: Mitoxantrone
    Cytotoxicity against rat C6 cells after 24 hrs by MTT assay
    Cytotoxicity against rat C6 cells after 24 hrs by MTT assay
    		[PMID: 26599534]
    MDA-MB-435 IC50
    0.35 1
    Compound: Mitoxantrone
    Antiproliferative activity against MDA435/LCC6 cells by ELISA
    Antiproliferative activity against MDA435/LCC6 cells by ELISA
    		[PMID: 17154505]
    A549 IC50
    0.07 3
    Compound: Mitoxantrone
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
    		[PMID: 35931243]
    A549 IC50
    0.3 3
    Compound: Mitoxantrone
    Inhibitory concentration of compound against proliferation of lung carcinoma A549 cell line
    Inhibitory concentration of compound against proliferation of lung carcinoma A549 cell line
    		[PMID: 12031316]
    Caco-2 IC50
    > 10 3
    Compound: 1
    Cytotoxicity against NAE-knockdown human Caco2 cells after 72 hrs by MTT assay
    Cytotoxicity against NAE-knockdown human Caco2 cells after 72 hrs by MTT assay
    		[PMID: 29232579]
    A2780 IC50
    0.55 1
    Compound: Mitoxantrone
    Concentration required to inhibit A2780-cell growth by 50%
    Concentration required to inhibit A2780-cell growth by 50%
    		[PMID: 9703471]
    A2780 IC50
    0.55 1
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
    Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs
    		[PMID: 9371240]
    A549 IC50
    0.3 3
    Compound: Mitoxantrone
    In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis)
    In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis)
    		[PMID: 12036369]
    Caco-2 IC50
    1.4 3
    Compound: 1
    Cytotoxicity against human Caco2 cells after 72 hrs by MTT assay
    Cytotoxicity against human Caco2 cells after 72 hrs by MTT assay
    		[PMID: 29232579]
    A549 IC50
    15.7 6
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 26599534]
    Cancer cell lines IC50
    0.75 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human H460M cancer cell line was determined after 144 hr
    Cytotoxicity against human H460M cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    G-361 IC50
    0.65 1
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit G-361 cell growth by 50%
    Cytotoxic potency required to inhibit G-361 cell growth by 50%
    		[PMID: 9371240]
    A549 IC50
    25.3 6
    Compound: Mito
    Cytotoxicity against Homo sapiens (human) A549 cells after 24 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) A549 cells after 24 hr by MTT assay
    		10.1007/s00044-012-0325-2
    Cancer cell lines IC50
    0.75 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human H460M cancer cell line was determined after 144 hr
    Cytotoxicity against human H460M cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    Cancer cell lines IC50
    0.85 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human H460M cancer cell line was determined after 1 hr
    Cytotoxicity against human H460M cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    Bone marrow cell GI50
    7 3
    Compound: Mitoxantrone
    Growth inhibition of human bone marrow cells
    Growth inhibition of human bone marrow cells
    		[PMID: 29995404]
    A549 IC50
    3 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    Cancer cell lines IC50
    6.8 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human MKN45 cancer cell line was determined after 1 hr
    Cytotoxicity against human MKN45 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    A549 IC50
    3.1 1
    Compound: Mitoxantrone
    Tested against A549 lung carcinoma in the sulforhodamine B assay.
    Tested against A549 lung carcinoma in the sulforhodamine B assay.
    		[PMID: 8648600]
    Cancer cell lines IC50
    75 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human PC3 cancer cell line was determined after 1 hr
    Cytotoxicity against human PC3 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    HL-60 IC50
    0.81 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound)
    		[PMID: 10479282]
    CCD 19Lu IC50
    > 160 1
    Compound: Mitoxantrone
    Cytotoxicity in human CCD-19Lu cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity in human CCD-19Lu cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 30108778]
    Cancer cell lines IC50
    0.85 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human H460M cancer cell line was determined after 1 hr
    Cytotoxicity against human H460M cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    A549 IC50
    3.1 1
    Compound: mitoxantrone
    Activity against A549 cancer cell line.
    Activity against A549 cancer cell line.
    		[PMID: 8960558]
    CCRF-CEM IC50
    0.036 3
    Compound: mitoxantrone
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    A549 IC50
    7.25 3
    Compound: Table S1, R142C2
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 30684866]
    C6 IC50
    11 6
    Compound: Mitoxantrone
    Cytotoxicity against rat C6 cells after 24 hrs by MTT assay
    Cytotoxicity against rat C6 cells after 24 hrs by MTT assay
    		[PMID: 26599534]
    A549 IC50
    7.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 21458279]
    C6 IC50
    10.9 6
    Compound: Mito
    Cytotoxicity against Rattus norvegicus (rat) C6 cells after 24 hr by MTT assay
    Cytotoxicity against Rattus norvegicus (rat) C6 cells after 24 hr by MTT assay
    		10.1007/s00044-012-0325-2
    CH1 IC50
    0.00265 3
    Compound: Mitoxantrone
    Concentration required to inhibit CH1-cell growth by 50%
    Concentration required to inhibit CH1-cell growth by 50%
    		[PMID: 9703471]
    CH1 IC50
    0.00265 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit CH1 cell growth by 50%
    Cytotoxic potency required to inhibit CH1 cell growth by 50%
    		[PMID: 9371240]
    Caco-2 IC50
    1.4 3
    Compound: 1
    Cytotoxicity against human Caco2 cells after 72 hrs by MTT assay
    Cytotoxicity against human Caco2 cells after 72 hrs by MTT assay
    		[PMID: 29232579]
    A549 IC50
    7.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    A549 IC50
    7.83 3
    Compound: MX
    Cytotoxicity against human A549 cells after 72 hrs
    Cytotoxicity against human A549 cells after 72 hrs
    		[PMID: 21354791]
    Caco-2 IC50
    >10 3
    Compound: 1
    Cytotoxicity against NAE-knockdown human Caco2 cells after 72 hrs by MTT assay
    Cytotoxicity against NAE-knockdown human Caco2 cells after 72 hrs by MTT assay
    		[PMID: 29232579]
    CHO IC50
    22.5 3
    Compound: mitoxantrone
    Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
    Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
    		[PMID: 23812503]
    A549 IC50
    8 3
    Compound: Mitoxantrone
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 19615900]
    CCRF-CEM IC50
    0.036 3
    Compound: mitoxantrone
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    Daudi IC50
    0.005 3
    Compound: Mit
    Antiproliferative activity against human Daudi cells after 72 hrs by MTT assay
    Antiproliferative activity against human Daudi cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    G-361 IC50
    0.00065 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit G-361 cell growth by 50%
    Cytotoxic potency required to inhibit G-361 cell growth by 50%
    		[PMID: 9371240]
    CCRF-CEM IC50
    3.6 3
    Compound: Mitoxantrone
    Cytotoxicity in human leukemic CCRF-CEM cells.
    Cytotoxicity in human leukemic CCRF-CEM cells.
    		[PMID: 14667232]
    H22 IC50
    187 1
    Compound: Mitoxantrone
    Dark toxicity against mouse H22 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Dark toxicity against mouse H22 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    CH1 IC50
    0.00265 3
    Compound: Mitoxantrone
    Concentration required to inhibit CH1-cell growth by 50%
    Concentration required to inhibit CH1-cell growth by 50%
    		[PMID: 9703471]
    HaCaT IC50
    3.9 3
    Compound: Mitoxantrone
    Cytotoxicity against human HaCaT cells by Cell titre-blue assay
    Cytotoxicity against human HaCaT cells by Cell titre-blue assay
    		[PMID: 26684177]
    CH1 IC50
    0.00265 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit CH1 cell growth by 50%
    Cytotoxic potency required to inhibit CH1 cell growth by 50%
    		[PMID: 9371240]
    HCC78 IC50
    13.83 1
    Compound: Mitoxantrone
    Cytotoxicity in human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity in human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 30108778]
    CHO IC50
    22.5 3
    Compound: mitoxantrone
    Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
    Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
    		[PMID: 23812503]
    A549 IC50
    3 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HCT-116 IC50
    0.022 3
    Compound: Mx
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    HCT-116 IC50
    0.025 3
    Compound: Mit
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    A549 IC50
    3.1 1
    Compound: mitoxantrone
    Activity against A549 cancer cell line.
    Activity against A549 cancer cell line.
    		[PMID: 8960558]
    HCT-116 IC50
    1.61 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    A549 IC50
    3.1 1
    Compound: Mitoxantrone
    Tested against A549 lung carcinoma in the sulforhodamine B assay.
    Tested against A549 lung carcinoma in the sulforhodamine B assay.
    		[PMID: 8648600]
    HCT-116 IC50
    110 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human HCT116 cancer cell line was determined after 1 hr
    Cytotoxicity against human HCT116 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    LoVo IC50
    3.3 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human LoVo cancer cell line was determined after 144 hr
    Cytotoxicity against human LoVo cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    HCT-116 IC50
    3.96 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells by MTT assay
    Cytotoxicity against human HCT116 cells by MTT assay
    		[PMID: 20951582]
    HL-60 IC50
    4 1
    Compound: MITO
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    		[PMID: 29945793]
    HL-60 IC50
    4 1
    Compound: MITO
    Cytotoxicity against human HL60 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HL60 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28342398]
    HCT-116 IC50
    5.8 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human HCT116 cancer cell line was determined after 144 hr
    Cytotoxicity against human HCT116 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    HCT-116 IC50
    7.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    P388 IC50
    4.3 1
    Compound: Mitoxantrone
    Antiproliferative activity against P388 cells by ELISA
    Antiproliferative activity against P388 cells by ELISA
    		[PMID: 17154505]
    Daudi IC50
    0.005 3
    Compound: Mit
    Antiproliferative activity against human Daudi cells after 72 hrs by MTT assay
    Antiproliferative activity against human Daudi cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    HCT-116 IC50
    7.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells by MTT assay
    Cytotoxicity against human HCT116 cells by MTT assay
    		[PMID: 21458279]
    HEK293 IC50
    0.4 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
    		[PMID: 23241029]
    L1210 IC50
    5 1
    Compound: Mitoxantrone
    Anti-tumor activity against murine L1210 sensitive cell line by using MTT assay
    Anti-tumor activity against murine L1210 sensitive cell line by using MTT assay
    		[PMID: 7699715]
    Bel-7402 IC50
    116.6 1
    Compound: Mitoxantrone
    Cytotoxicity against human Bel7402 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human Bel7402 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    HEK293 IC50
    0.53 3
    Compound: mitoxantrone
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    DU-145 IC50
    5.6 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145
    		[PMID: 10479282]
    Bone marrow cell GI50
    7 3
    Compound: Mitoxantrone
    Growth inhibition of human bone marrow cells
    Growth inhibition of human bone marrow cells
    		[PMID: 29995404]
    HEK293 IC50
    0.53 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    C6 IC50
    10.9 6
    Compound: Mito
    Cytotoxicity against Rattus norvegicus (rat) C6 cells after 24 hr by MTT assay
    Cytotoxicity against Rattus norvegicus (rat) C6 cells after 24 hr by MTT assay
    		10.1007/s00044-012-0325-2
    HaCaT IC50
    3.9 3
    Compound: Mitoxantrone
    Cytotoxicity against human HaCaT cells by Cell titre-blue assay
    Cytotoxicity against human HaCaT cells by Cell titre-blue assay
    		[PMID: 26684177]
    HEK293 IC50
    0.83 3
    Compound: mitoxantrone
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    HCT-116 IC50
    5.8 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human HCT116 cancer cell line was determined after 144 hr
    Cytotoxicity against human HCT116 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    C6 IC50
    11 6
    Compound: Mitoxantrone
    Cytotoxicity against rat C6 cells after 24 hrs by MTT assay
    Cytotoxicity against rat C6 cells after 24 hrs by MTT assay
    		[PMID: 26599534]
    HEK293 IC50
    10 1
    Compound: Mitoxantrone
    Cytotoxicity against HEK293 cells after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells after 72 hrs by MTT assay
    		[PMID: 24611893]
    OVCAR-3 IC50
    5.8 1
    Compound: mitoxantrone
    Antitumor activity against human ovarian OVCAR-3 cell lines.
    Antitumor activity against human ovarian OVCAR-3 cell lines.
    		[PMID: 8960558]
    CCD 19Lu IC50
    > 160 1
    Compound: Mitoxantrone
    Cytotoxicity in human CCD-19Lu cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity in human CCD-19Lu cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 30108778]
    HEK293 IC50
    11.7 1
    Compound: Mitoxantrone
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    		[PMID: 31465686]
    OVCAR-3 IC50
    5.8 1
    Compound: Mitoxantrone
    Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay
    Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay
    		[PMID: 7699715]
    HEK293 IC50
    26.6 1
    Compound: Mitoxantrone
    Cytotoxicity against HEK293 cells overexpressing ABCG2 after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells overexpressing ABCG2 after 72 hrs by MTT assay
    		[PMID: 24611893]
    OVCAR-3 IC50
    5.8 1
    Compound: Mitoxantrone
    Inhibitory activity against OVCAR-3 cell line
    Inhibitory activity against OVCAR-3 cell line
    		[PMID: 8648600]
    HCT-116 IC50
    1.61 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    CCRF-CEM IC50
    0.036 3
    Compound: mitoxantrone
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    HEK293 IC50
    43.9 3
    Compound: mitoxantrone
    Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    HCT-116 IC50
    0.025 3
    Compound: Mit
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    CCRF-CEM IC50
    3.6 3
    Compound: Mitoxantrone
    Cytotoxicity in human leukemic CCRF-CEM cells.
    Cytotoxicity in human leukemic CCRF-CEM cells.
    		[PMID: 14667232]
    HEK293 IC50
    60.5 3
    Compound: mitoxantrone
    Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    CH1 IC50
    0.00265 3
    Compound: Mitoxantrone
    Concentration required to inhibit CH1-cell growth by 50%
    Concentration required to inhibit CH1-cell growth by 50%
    		[PMID: 9703471]
    OVCAR-3 IC50
    6 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line OVCAR-3, a resistant ovarian carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line OVCAR-3, a resistant ovarian carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HEK293 IC50
    73.3 3
    Compound: mitoxantrone
    Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    HEK-293T IC50
    < 0.1 3
    Compound: mitoxantrone
    Cytotoxicity against human 293T cells expressing telomerase after 96 hrs by MTT assay
    Cytotoxicity against human 293T cells expressing telomerase after 96 hrs by MTT assay
    		[PMID: 18754611]
    CH1 IC50
    0.00265 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit CH1 cell growth by 50%
    Cytotoxic potency required to inhibit CH1 cell growth by 50%
    		[PMID: 9371240]
    A2780 IC50
    6.11 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780
    		[PMID: 10479282]
    HeLa IC50
    < 0.1 3
    Compound: mitoxantrone
    Cytotoxicity against human HeLa cells expressing telomerase after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells expressing telomerase after 96 hrs by MTT assay
    		[PMID: 18754611]
    CHO IC50
    22.5 3
    Compound: mitoxantrone
    Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
    Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
    		[PMID: 23812503]
    HCT-116 IC50
    7.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    HCT-116 IC50
    0.022 3
    Compound: Mx
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    HeLa IC50
    0.044 3
    Compound: Mit
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    HeLa EC50
    0.55 6
    Compound: 4
    Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
    Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
    		[PMID: 3172129]
    HCT-116 IC50
    3.96 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells by MTT assay
    Cytotoxicity against human HCT116 cells by MTT assay
    		[PMID: 20951582]
    HeLa IC50
    2.35 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    HCT-116 IC50
    7.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells by MTT assay
    Cytotoxicity against human HCT116 cells by MTT assay
    		[PMID: 21458279]
    HepG2 IC50
    11.05 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 24794747]
    Cancer cell lines IC50
    6.8 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human MKN45 cancer cell line was determined after 1 hr
    Cytotoxicity against human MKN45 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    HepG2 IC50
    15.33 3
    Compound: MTZ
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33191085]
    PC-3 IC50
    7 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human PC3 cancer cell line was determined after 144 hr
    Cytotoxicity against human PC3 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    HepG2 IC50
    18.6 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    K562 IC50
    7.06 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 hr exposure to compound)
    		[PMID: 10479282]
    HL-60 IC50
    0.0025 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    		[PMID: 22944121]
    PC-3 IC50
    7.1 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line PC3
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line PC3
    		[PMID: 10479282]
    HL-60 GI50
    0.01 3
    Compound: mitoxantrone
    Growth inhibition of human HL60 cells by Almar blue assay
    Growth inhibition of human HL60 cells by Almar blue assay
    		[PMID: 17418582]
    2008 IC50
    7.8 1
    Compound: Mitoxantrone
    Antiproliferative activity against human 2008 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    Antiproliferative activity against human 2008 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    		[PMID: 31465686]
    HL-60 IC50
    0.016 3
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    WiDr IC50
    8 1
    Compound: mitoxantrone
    Tested for inhibitory activity against a sensitive strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    Tested for inhibitory activity against a sensitive strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    		[PMID: 10956214]
    HL-60 IC50
    0.024 1
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
    		[PMID: 30485090]
    WiDr IC50
    8.1 1
    Compound: mitoxantrone
    Activity against human colon carcinoma sensitive WiDr cell line.
    Activity against human colon carcinoma sensitive WiDr cell line.
    		[PMID: 8960558]
    HL-60 IC50
    0.063 3
    Compound: MX
    Cytotoxicity against human HL60 cells after 72 hrs
    Cytotoxicity against human HL60 cells after 72 hrs
    		[PMID: 20961767]
    WiDr IC50
    8.1 1
    Compound: Mitoxantrone
    Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
    Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
    		[PMID: 8648600]
    HL-60 IC50
    0.063 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs
    Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs
    		[PMID: 18507368]
    MCF7 IC50
    8.7 1
    Compound: mitoxantrone
    Antitumor activity against human mammary carcinoma sensitive MXF7 breast cell line.
    Antitumor activity against human mammary carcinoma sensitive MXF7 breast cell line.
    		[PMID: 8960558]
    HL-60 GI50
    0.192 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human HL60 cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    MCF7 IC50
    8.7 1
    Compound: Mitoxantrone
    Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
    Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
    		[PMID: 8648600]
    MCF7 IC50
    9 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line MCF7, a strain sensitive to doxorubicin of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line MCF7, a strain sensitive to doxorubicin of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HL-60 IC50
    0.29 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    HL-60 GI50
    0.33 1
    Compound: MX, mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 17962028]
    L1210 IC50
    9.7 1
    Compound: mitoxantrone
    Antitumor activity against sensitive L1210 murine leukemia cell lines.
    Antitumor activity against sensitive L1210 murine leukemia cell lines.
    		[PMID: 8960558]
    L1210 IC50
    9.7 1
    Compound: Mitoxantrone
    Inhibitory activity against sensitive L1210 cell lines
    Inhibitory activity against sensitive L1210 cell lines
    		[PMID: 8648600]
    HL-60 IC50
    1.51 3
    Compound: MX
    Cytotoxicity against human HL60/MX2 cells after 72 hrs
    Cytotoxicity against human HL60/MX2 cells after 72 hrs
    		[PMID: 20961767]
    HL-60 IC50
    4 1
    Compound: MITO
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    		[PMID: 29945793]
    Caco-2 IC50
    1.4 3
    Compound: 1
    Cytotoxicity against human Caco2 cells after 72 hrs by MTT assay
    Cytotoxicity against human Caco2 cells after 72 hrs by MTT assay
    		[PMID: 29232579]
    HEK293 IC50
    10 1
    Compound: Mitoxantrone
    Cytotoxicity against HEK293 cells after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells after 72 hrs by MTT assay
    		[PMID: 24611893]
    HL-60 IC50
    4 1
    Compound: MITO
    Cytotoxicity against human HL60 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HL60 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28342398]
    Caco-2 IC50
    > 10 3
    Compound: 1
    Cytotoxicity against NAE-knockdown human Caco2 cells after 72 hrs by MTT assay
    Cytotoxicity against NAE-knockdown human Caco2 cells after 72 hrs by MTT assay
    		[PMID: 29232579]
    HT-29 IC50
    10 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity is determined as the concentration required to inhibit the growth of human colon adenocarcinoma (HT-29) cell line
    Cytotoxicity is determined as the concentration required to inhibit the growth of human colon adenocarcinoma (HT-29) cell line
    		[PMID: 15456268]
    HL-60 IC50
    6.3 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 19615900]
    HT-29 IC50
    10 1
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxic potency against HT-29 (human colon adenocarcinoma) cell line.
    In vitro cytotoxic potency against HT-29 (human colon adenocarcinoma) cell line.
    		[PMID: 11806721]
    L1210 IC50
    10 1
    Compound: mitoxantrone
    Tested for inhibitory activity against murine cell line L12110, a strain sensitive to doxorubicin using MTT assay.
    Tested for inhibitory activity against murine cell line L12110, a strain sensitive to doxorubicin using MTT assay.
    		[PMID: 10956214]
    HL-60 IC50
    6.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 19926279]
    HEK293 IC50
    0.04 3
    Compound: MX
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    		[PMID: 36780419]
    HL-60 IC50
    7.5 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 20951582]
    HL-60 GI50
    7.8 3
    Compound: Mitoxantrone
    Growth inhibition of human HL60 cells by MTT assay
    Growth inhibition of human HL60 cells by MTT assay
    		[PMID: 20153184]
    HEK293 IC50
    1.72 3
    Compound: MX
    Cytotoxicity against human HEK293 cells expressing ABCG2 assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human HEK293 cells expressing ABCG2 assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    		[PMID: 36780419]
    WiDr IC50
    10 1
    Compound: Mitoxantrone
    Activity against sensitive cell line of WiDr human colon tumor
    Activity against sensitive cell line of WiDr human colon tumor
    		[PMID: 7699715]
    HL-60 IC50
    7.9 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 21458279]
    HL-60 IC50
    8.1 3
    Compound: MX
    Cytotoxicity against human HL60 cells after 72 hrs
    Cytotoxicity against human HL60 cells after 72 hrs
    		[PMID: 21354791]
    Cancer cell lines IC50
    0.75 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human H460M cancer cell line was determined after 144 hr
    Cytotoxicity against human H460M cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    L1210 IC50
    11.4 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 hr exposure to compound)
    		[PMID: 10479282]
    HL-60 IC50
    8.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    HEK293 IC50
    11.7 1
    Compound: Mitoxantrone
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    		[PMID: 31465686]
    Cancer cell lines IC50
    0.85 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human H460M cancer cell line was determined after 1 hr
    Cytotoxicity against human H460M cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    Cancer cell lines IC50
    6.8 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human MKN45 cancer cell line was determined after 1 hr
    Cytotoxicity against human MKN45 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    HL60/MX2 IC50
    0.561 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    		[PMID: 22944121]
    HEK293 IC50
    0.4 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
    		[PMID: 23241029]
    HL60/MX2 IC50
    1.51 3
    Compound: MX, mitoxantrone
    Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs
    Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs
    		[PMID: 18507368]
    Cancer cell lines IC50
    75 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human PC3 cancer cell line was determined after 1 hr
    Cytotoxicity against human PC3 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    HEK293 IC50
    0.53 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    HL60/MX2 IC50
    148 1
    Compound: MITO
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    		[PMID: 29945793]
    HEK293 IC50
    0.83 3
    Compound: mitoxantrone
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    LoVo IC50
    12 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human LoVo cancer cell line was determined after 1 hr
    Cytotoxicity against human LoVo cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    HL60/MX2 IC50
    148 1
    Compound: MITO
    Cytotoxicity against human HL60/MX2 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HL60/MX2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28342398]
    MKN-45 IC50
    12 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human MKN45 cancer cell line was determined after 144 hr
    Cytotoxicity against human MKN45 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    HL60/MX2 GI50
    26 1
    Compound: MX, mitoxantrone
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    		[PMID: 17962028]
    HL60/MX2 GI50
    4.42 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60/MX2 cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human HL60/MX2 cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    HEK293 IC50
    43.9 3
    Compound: mitoxantrone
    Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    DU-145 IC50
    5.6 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line DU145
    		[PMID: 10479282]
    HT-29 IC50
    0.01 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit HT-29 cell growth by 50% after cell drug contact for 144 hrs
    Cytotoxic potency required to inhibit HT-29 cell growth by 50% after cell drug contact for 144 hrs
    		[PMID: 9371240]
    Daudi IC50
    0.005 3
    Compound: Mit
    Antiproliferative activity against human Daudi cells after 72 hrs by MTT assay
    Antiproliferative activity against human Daudi cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    HEK293 IC50
    73.3 3
    Compound: mitoxantrone
    Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    HEK293 IC50
    60.5 3
    Compound: mitoxantrone
    Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    HT-29 IC50
    0.01 3
    Compound: MX
    Concentration required to inhibit cell growth by 50% in vitro against Human colon adenocarcinoma cell line
    Concentration required to inhibit cell growth by 50% in vitro against Human colon adenocarcinoma cell line
    		[PMID: 11563932]
    HT-29 IC50
    0.025 3
    Compound: Mx
    Antiproliferative activity against HT29 cells by MTT assay after 72 hrs
    Antiproliferative activity against HT29 cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    HCC78 IC50
    13.83 1
    Compound: Mitoxantrone
    Cytotoxicity in human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity in human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 30108778]
    G-361 IC50
    0.00065 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit G-361 cell growth by 50%
    Cytotoxic potency required to inhibit G-361 cell growth by 50%
    		[PMID: 9371240]
    HT-29 IC50
    21.65 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    HEK-293T IC50
    <0.1 3
    Compound: mitoxantrone
    Cytotoxicity against human 293T cells expressing telomerase after 96 hrs by MTT assay
    Cytotoxicity against human 293T cells expressing telomerase after 96 hrs by MTT assay
    		[PMID: 18754611]
    HT-29 IC50
    8.7 3
    Compound: Mitoxantrone
    Cytotoxicity against human HT-29 cells by MTT assay
    Cytotoxicity against human HT-29 cells by MTT assay
    		[PMID: 19615900]
    HeLa EC50
    0.55 6
    Compound: 4
    Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
    Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
    		[PMID: 3172129]
    HT-29 GI50
    8.9 3
    Compound: Mitoxantrone
    Growth inhibition of human HT-29 cells by MTT assay
    Growth inhibition of human HT-29 cells by MTT assay
    		[PMID: 20153184]
    HeLa IC50
    2.35 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    H22 IC50
    187 1
    Compound: Mitoxantrone
    Dark toxicity against mouse H22 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Dark toxicity against mouse H22 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    HeLa IC50
    0.044 3
    Compound: Mit
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    Ishikawa IC50
    0.01 3
    Compound: Mit
    Antiproliferative activity against human Ishikawa cells after 72 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    HeLa IC50
    0.04 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth
    		[PMID: 35931243]
    K562 IC50
    0.0026 3
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    		[PMID: 18076140]
    HeLa IC50
    <0.1 3
    Compound: mitoxantrone
    Cytotoxicity against human HeLa cells expressing telomerase after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells expressing telomerase after 96 hrs by MTT assay
    		[PMID: 18754611]
    K562 IC50
    0.0334 6
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    K562 IC50
    0.42 3
    Compound: Mitoxantrone
    Growth inhibition of human K562 cells after 72 hrs by MTS method
    Growth inhibition of human K562 cells after 72 hrs by MTS method
    		[PMID: 18258442]
    LoVo IC50
    17.1 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo
    		[PMID: 10479282]
    K562 IC50
    0.51 3
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    HepG2 IC50
    11.05 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 24794747]
    K562 IC50
    2 6
    Compound: mitoxanthrone
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 12027731]
    HepG2 IC50
    18.6 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    K562 IC50
    2.35 3
    Compound: MTZ
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33191085]
    HepG2 IC50
    15.33 3
    Compound: MTZ
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33191085]
    HT-29 IC50
    19.6 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29
    		[PMID: 10479282]
    K562 IC50
    4.55 3
    Compound: Mitoxantrone
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    HL-60 GI50
    0.192 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human HL60 cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    KB EC50
    0.355 6
    Compound: Mitoxantrone
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    KB EC50
    0.36 3
    Compound: mitoxantrone
    Antiproliferative activity against human KB/HeLa cells after 48 hrs
    Antiproliferative activity against human KB/HeLa cells after 48 hrs
    		[PMID: 23395656]
    HL-60 GI50
    0.01 3
    Compound: mitoxantrone
    Growth inhibition of human HL60 cells by Almar blue assay
    Growth inhibition of human HL60 cells by Almar blue assay
    		[PMID: 17418582]
    KB EC50
    0.42 3
    Compound: Mitoxantrone
    Cytotoxicity against human KB/HeLa cells after 48 hrs by resazurin dye assay
    Cytotoxicity against human KB/HeLa cells after 48 hrs by resazurin dye assay
    		[PMID: 23988351]
    HL-60 GI50
    7.8 3
    Compound: Mitoxantrone
    Growth inhibition of human HL60 cells by MTT assay
    Growth inhibition of human HL60 cells by MTT assay
    		[PMID: 20153184]
    L1210 EC50
    > 5 6
    Compound: 4
    Effective concentration required to inhibit by 50% the growth of L1210 cells
    Effective concentration required to inhibit by 50% the growth of L1210 cells
    		[PMID: 3172129]
    HL-60 IC50
    0.0025 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    		[PMID: 22944121]
    L1210 IC50
    0.00004 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
    Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
    		[PMID: 9371240]
    HL-60 IC50
    0.063 3
    Compound: MTX, NOVANTRONE
    Cytotoxicity against human HL60 cells
    Cytotoxicity against human HL60 cells
    		[PMID: 21439821]
    HL-60 IC50
    8.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    L1210 IC50
    10 1
    Compound: mitoxantrone
    Tested for inhibitory activity against murine cell line L12110, a strain sensitive to doxorubicin using MTT assay.
    Tested for inhibitory activity against murine cell line L12110, a strain sensitive to doxorubicin using MTT assay.
    		[PMID: 10956214]
    HL-60 IC50
    0.29 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    HCC78 IC50
    13.83 1
    Compound: Mitoxantrone
    Cytotoxicity in human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity in human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 30108778]
    L1210 IC50
    15 3
    Compound: Mitoxantrone
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28222315]
    HL-60 IC50
    0.063 3
    Compound: MX
    Cytotoxicity against human HL60 cells after 72 hrs
    Cytotoxicity against human HL60 cells after 72 hrs
    		[PMID: 20961767]
    L1210 IC50
    39 1
    Compound: Mitoxantrone
    Antitumor activity against murine L1210 resistant cell line by using MTT assay
    Antitumor activity against murine L1210 resistant cell line by using MTT assay
    		[PMID: 7699715]
    HL-60 IC50
    8.1 3
    Compound: MX
    Cytotoxicity against human HL60 cells after 72 hrs
    Cytotoxicity against human HL60 cells after 72 hrs
    		[PMID: 21354791]
    HCT-116 IC50
    0.022 3
    Compound: Mx
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    L1210 IC50
    39 1
    Compound: mitoxantrone
    Tested for inhibitory activity against murine cell line L12110, a strain resistant to doxorubicin using MTT assay.
    Tested for inhibitory activity against murine cell line L12110, a strain resistant to doxorubicin using MTT assay.
    		[PMID: 10956214]
    HCT-116 IC50
    0.025 3
    Compound: Mit
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    HL-60 IC50
    0.016 3
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    L1210 IC50
    5 1
    Compound: Mitoxantrone
    Anti-tumor activity against murine L1210 sensitive cell line by using MTT assay
    Anti-tumor activity against murine L1210 sensitive cell line by using MTT assay
    		[PMID: 7699715]
    LoVo IC50
    12 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human LoVo cancer cell line was determined after 1 hr
    Cytotoxicity against human LoVo cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    HCT-116 IC50
    1.61 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    HL-60 IC50
    6.3 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 19615900]
    HL-60 IC50
    6.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 19926279]
    HCT-116 IC50
    110 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human HCT116 cancer cell line was determined after 1 hr
    Cytotoxicity against human HCT116 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    LoVo IC50
    3.3 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human LoVo cancer cell line was determined after 144 hr
    Cytotoxicity against human LoVo cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    HCT-116 IC50
    3.96 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells by MTT assay
    Cytotoxicity against human HCT116 cells by MTT assay
    		[PMID: 20951582]
    HL-60 IC50
    7.5 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 20951582]
    MCF7 GI50
    3.93 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    MCF7 IC50
    380.2 1
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    HCT-116 IC50
    5.8 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human HCT116 cancer cell line was determined after 144 hr
    Cytotoxicity against human HCT116 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    HL-60 IC50
    7.9 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 21458279]
    HCT-116 IC50
    7.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells by MTT assay
    Cytotoxicity against human HCT116 cells by MTT assay
    		[PMID: 21458279]
    HL-60 IC50
    1.51 3
    Compound: MX
    Cytotoxicity against human HL60/MX2 cells after 72 hrs
    Cytotoxicity against human HL60/MX2 cells after 72 hrs
    		[PMID: 20961767]
    MCF7 IC50
    41 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line MCF7, a strain resistant to mitoxantrone of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line MCF7, a strain resistant to mitoxantrone of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HL-60 IC50
    0.063 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs
    Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs
    		[PMID: 18507368]
    HCT-116 IC50
    7.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    MCF7 IC50
    7.1 3
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 21458279]
    MCF7 IC50
    7.1 3
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 19615900]
    HEK-293T IC50
    < 0.1 3
    Compound: mitoxantrone
    Cytotoxicity against human 293T cells expressing telomerase after 96 hrs by MTT assay
    Cytotoxicity against human 293T cells expressing telomerase after 96 hrs by MTT assay
    		[PMID: 18754611]
    HL-60 IC50
    3.35 3
    Compound: mitoxantrone
    Relative cytotoxicity against Human promyelocytic Leukemia(HL-60) cells; Value is in range, activity expressed as IC50
    Relative cytotoxicity against Human promyelocytic Leukemia(HL-60) cells; Value is in range, activity expressed as IC50
    		[PMID: 10377219]
    HL60/MX2 GI50
    4.42 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60/MX2 cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human HL60/MX2 cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    HEK293 IC50
    0.04 3
    Compound: MX
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    		[PMID: 36780419]
    MCF7 IC50
    72 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line D40, a strain resistant to doxorubicin of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line D40, a strain resistant to doxorubicin of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HEK293 IC50
    0.4 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
    		[PMID: 23241029]
    HL60/MX2 IC50
    0.561 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    		[PMID: 22944121]
    MCF7 IC50
    9 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line MCF7, a strain sensitive to doxorubicin of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line MCF7, a strain sensitive to doxorubicin of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HL60/MX2 IC50
    1.51 3
    Compound: MTX, NOVANTRONE
    Cytotoxicity against human HL60/MX2 cells
    Cytotoxicity against human HL60/MX2 cells
    		[PMID: 21439821]
    HEK293 IC50
    0.53 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    MDA-MB-231 IC50
    0.96 3
    Compound: mitoxantrone
    Antiproliferative activity against human MDA-MB-231 cells by WST-1 method after 72 hrs
    Antiproliferative activity against human MDA-MB-231 cells by WST-1 method after 72 hrs
    		[PMID: 17335189]
    L1210 IC50
    21 1
    Compound: Mitoxantrone
    An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
    An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
    		[PMID: 8648600]
    HEK293 IC50
    0.53 3
    Compound: mitoxantrone
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    MDA-MB-435 IC50
    0.35 1
    Compound: Mitoxantrone
    Antiproliferative activity against MDA435/LCC6 cells by ELISA
    Antiproliferative activity against MDA435/LCC6 cells by ELISA
    		[PMID: 17154505]
    HL60/MX2 IC50
    1.51 3
    Compound: MX, mitoxantrone
    Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs
    Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs
    		[PMID: 18507368]
    HEK293 IC50
    0.83 3
    Compound: mitoxantrone
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    MDA-MB-435 IC50
    1442 1
    Compound: Mitoxantrone
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA
    		[PMID: 17154505]
    HT-29 GI50
    8.9 3
    Compound: Mitoxantrone
    Growth inhibition of human HT-29 cells by MTT assay
    Growth inhibition of human HT-29 cells by MTT assay
    		[PMID: 20153184]
    HEK293 IC50
    1.72 3
    Compound: MX
    Cytotoxicity against human HEK293 cells expressing ABCG2 assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Cytotoxicity against human HEK293 cells expressing ABCG2 assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    		[PMID: 36780419]
    MDA-MB-435 IC50
    646 1
    Compound: Mitoxantrone
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    		[PMID: 17154505]
    HEK293 IC50
    10 1
    Compound: Mitoxantrone
    Cytotoxicity against HEK293 cells after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells after 72 hrs by MTT assay
    		[PMID: 24611893]
    MDCK-II IC50
    0.19 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
    		[PMID: 23241029]
    HT-29 IC50
    0.025 3
    Compound: Mx
    Antiproliferative activity against HT29 cells by MTT assay after 72 hrs
    Antiproliferative activity against HT29 cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    HT-29 IC50
    21.65 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    MES-SA IC50
    0.003 3
    Compound: Mx
    Antiproliferative activity against MES-SA cells by MTT assay after 72 hrs
    Antiproliferative activity against MES-SA cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    HEK293 IC50
    11.7 1
    Compound: Mitoxantrone
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 5 days by MTS/PMS assay
    		[PMID: 31465686]
    HEK293 IC50
    26.6 1
    Compound: Mitoxantrone
    Cytotoxicity against HEK293 cells overexpressing ABCG2 after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells overexpressing ABCG2 after 72 hrs by MTT assay
    		[PMID: 24611893]
    MES-SA IC50
    0.006 3
    Compound: Mit
    Antiproliferative activity against human MES-SA cells after 72 hrs by MTT assay
    Antiproliferative activity against human MES-SA cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    HT-29 IC50
    0.01 3
    Compound: MX
    Concentration required to inhibit cell growth by 50% in vitro against Human colon adenocarcinoma cell line
    Concentration required to inhibit cell growth by 50% in vitro against Human colon adenocarcinoma cell line
    		[PMID: 11563932]
    MES-SA IC50
    0.012 3
    Compound: Mx
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    HT-29 IC50
    0.01 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit HT-29 cell growth by 50% after cell drug contact for 144 hrs
    Cytotoxic potency required to inhibit HT-29 cell growth by 50% after cell drug contact for 144 hrs
    		[PMID: 9371240]
    HEK293 IC50
    43.9 3
    Compound: mitoxantrone
    Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    MES-SA/Dx5 IC50
    0.028 3
    Compound: Mx
    Antiproliferative activity against doxorubicin-resistant MES-SA/Dx5 cells by MTT assay after 72 hrs
    Antiproliferative activity against doxorubicin-resistant MES-SA/Dx5 cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    HT-29 IC50
    8.7 3
    Compound: Mitoxantrone
    Cytotoxicity against human HT-29 cells by MTT assay
    Cytotoxicity against human HT-29 cells by MTT assay
    		[PMID: 19615900]
    HEK293 IC50
    60.5 3
    Compound: mitoxantrone
    Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    HEK293 IC50
    73.3 3
    Compound: mitoxantrone
    Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
    		[PMID: 23241029]
    HT-29 IC50
    8 3
    Compound: Mitoxantrone
    In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis)
    In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis)
    		[PMID: 12036369]
    MES-SA/Dx5 IC50
    0.073 3
    Compound: Mit
    Antiproliferative activity against human MES-SA/Dx5 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MES-SA/Dx5 cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    MES-SA/Dx5 IC50
    0.08 3
    Compound: Mx
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    HT-29 IC50
    0.02 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity against colorectal adenocarcinoma HT-29 cells
    In vitro cytotoxicity against colorectal adenocarcinoma HT-29 cells
    		[PMID: 16169719]
    HT-29 IC50
    0.01 3
    Compound: Mitoxantrone
    In vitro cytotoxicity was tested against human colon adenocarcinoma HT-29 cell line
    In vitro cytotoxicity was tested against human colon adenocarcinoma HT-29 cell line
    		[PMID: 10411474]
    MKN-28 IC50
    0.02 6
    Compound: mitoxantrone
    Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
    Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    HT-29 IC50
    8 3
    Compound: Mitoxantrone
    Inhibitory concentration of compound against proliferation of colon carcinoma HT-29 cell line
    Inhibitory concentration of compound against proliferation of colon carcinoma HT-29 cell line
    		[PMID: 12031316]
    MKN-45 IC50
    12 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human MKN45 cancer cell line was determined after 144 hr
    Cytotoxicity against human MKN45 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    NCI-H460 EC50
    0.03 3
    Compound: Mitoxantrone
    Cytotoxicity against human NCI-H460 cells after 48 hrs by resazurin dye assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by resazurin dye assay
    		[PMID: 23988351]
    A2780 IC50
    25.1 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780/DX(RI)
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line A2780/DX(RI)
    		[PMID: 10479282]
    NCI-H460 EC50
    0.12 3
    Compound: mitoxantrone
    Antiproliferative activity against human NCI-H460 cells after 48 hrs
    Antiproliferative activity against human NCI-H460 cells after 48 hrs
    		[PMID: 23395656]
    HL-60 GI50
    0.01 3
    Compound: mitoxantrone
    Growth inhibition of human HL60 cells by Almar blue assay
    Growth inhibition of human HL60 cells by Almar blue assay
    		[PMID: 17418582]
    HL60/MX2 GI50
    26 1
    Compound: MX, mitoxantrone
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    		[PMID: 17962028]
    HL-60 GI50
    0.192 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human HL60 cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    NCI-H460 EC50
    0.1224 6
    Compound: Mitoxantrone
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    MCF7 IC50
    26 1
    Compound: mitoxantrone
    Cytotoxicity against human MCF7 cells
    Cytotoxicity against human MCF7 cells
    		[PMID: 25811651]
    NCI-H460 IC50
    0.36 3
    Compound: MX
    Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 2 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 2 hrs by MTT assay
    		[PMID: 31302589]
    HL-60 GI50
    0.33 1
    Compound: MX, mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 17962028]
    HEK293 IC50
    26.6 1
    Compound: Mitoxantrone
    Cytotoxicity against HEK293 cells overexpressing ABCG2 after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells overexpressing ABCG2 after 72 hrs by MTT assay
    		[PMID: 24611893]
    HL-60 GI50
    7.8 3
    Compound: Mitoxantrone
    Growth inhibition of human HL60 cells by MTT assay
    Growth inhibition of human HL60 cells by MTT assay
    		[PMID: 20153184]
    NCI-H460 GI50
    1.29 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    Ishikawa IC50
    0.01 3
    Compound: Mit
    Antiproliferative activity against human Ishikawa cells after 72 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    K562 IC50
    4.55 3
    Compound: Mitoxantrone
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    NIH3T3 IC50
    42 3
    Compound: Mitoxantrone
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28222315]
    HL-60 IC50
    0.0025 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    		[PMID: 22944121]
    OVCAR-3 IC50
    5.8 1
    Compound: Mitoxantrone
    Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay
    Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay
    		[PMID: 7699715]
    K562 IC50
    0.14 3
    Compound: Mitoxantrone
    Antiproliferative activity against human K562 cells assessed as inhibition of cell growth
    Antiproliferative activity against human K562 cells assessed as inhibition of cell growth
    		[PMID: 35931243]
    HL-60 IC50
    0.016 3
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    K562 IC50
    2.35 3
    Compound: MTZ
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33191085]
    OVCAR-3 IC50
    6 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line OVCAR-3, a resistant ovarian carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line OVCAR-3, a resistant ovarian carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HL-60 IC50
    0.024 1
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
    		[PMID: 30485090]
    P388 IC50
    4.3 1
    Compound: Mitoxantrone
    Antiproliferative activity against P388 cells by ELISA
    Antiproliferative activity against P388 cells by ELISA
    		[PMID: 17154505]
    K562 IC50
    0.0334 6
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    K562 IC50
    2 6
    Compound: mitoxanthrone
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 12027731]
    HL-60 IC50
    0.063 3
    Compound: MTX, NOVANTRONE
    Cytotoxicity against human HL60 cells
    Cytotoxicity against human HL60 cells
    		[PMID: 21439821]
    P388/ADR IC50
    194 1
    Compound: Mitoxantrone
    Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    		[PMID: 17154505]
    HL-60 IC50
    0.063 3
    Compound: MX
    Cytotoxicity against human HL60 cells after 72 hrs
    Cytotoxicity against human HL60 cells after 72 hrs
    		[PMID: 20961767]
    P388/ADR IC50
    395 1
    Compound: Mitoxantrone
    Antiproliferative activity against adriamycin resistant P388 cells by ELISA
    Antiproliferative activity against adriamycin resistant P388 cells by ELISA
    		[PMID: 17154505]
    K562 IC50
    0.0026 3
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    		[PMID: 18076140]
    K562 IC50
    0.51 3
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    HL-60 IC50
    0.063 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs
    Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs
    		[PMID: 18507368]
    PC-3 IC50
    0.29 3
    Compound: Mitoxantrone
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 22100139]
    K562 IC50
    0.42 3
    Compound: Mitoxantrone
    Growth inhibition of human K562 cells after 72 hrs by MTS method
    Growth inhibition of human K562 cells after 72 hrs by MTS method
    		[PMID: 18258442]
    PC-3 GI50
    0.78 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    HL-60 IC50
    0.29 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    HL-60 IC50
    0.81 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against HL60 human leukemia cell line (72 hr exposure to compound)
    		[PMID: 10479282]
    PC-3 IC50
    7 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human PC3 cancer cell line was determined after 144 hr
    Cytotoxicity against human PC3 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    KB EC50
    0.36 3
    Compound: mitoxantrone
    Antiproliferative activity against human KB/HeLa cells after 48 hrs
    Antiproliferative activity against human KB/HeLa cells after 48 hrs
    		[PMID: 23395656]
    KB EC50
    0.355 6
    Compound: Mitoxantrone
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    SF-268 EC50
    0.315 6
    Compound: Mitoxantrone
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    HL-60 IC50
    1.51 3
    Compound: MX
    Cytotoxicity against human HL60/MX2 cells after 72 hrs
    Cytotoxicity against human HL60/MX2 cells after 72 hrs
    		[PMID: 20961767]
    SF-268 EC50
    0.32 3
    Compound: mitoxantrone
    Antiproliferative activity against human SF268 cells after 48 hrs
    Antiproliferative activity against human SF268 cells after 48 hrs
    		[PMID: 23395656]
    HL-60 IC50
    3.35 3
    Compound: mitoxantrone
    Relative cytotoxicity against Human promyelocytic Leukemia(HL-60) cells; Value is in range, activity expressed as IC50
    Relative cytotoxicity against Human promyelocytic Leukemia(HL-60) cells; Value is in range, activity expressed as IC50
    		[PMID: 10377219]
    KB EC50
    0.42 3
    Compound: Mitoxantrone
    Cytotoxicity against human KB/HeLa cells after 48 hrs by resazurin dye assay
    Cytotoxicity against human KB/HeLa cells after 48 hrs by resazurin dye assay
    		[PMID: 23988351]
    SF-268 GI50
    0.97 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
    Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    L1210 IC50
    39 1
    Compound: Mitoxantrone
    Antitumor activity against murine L1210 resistant cell line by using MTT assay
    Antitumor activity against murine L1210 resistant cell line by using MTT assay
    		[PMID: 7699715]
    HL-60 IC50
    4 1
    Compound: MITO
    Cytotoxicity against human HL60 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HL60 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28342398]
    HL-60 IC50
    4 1
    Compound: MITO
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
    		[PMID: 29945793]
    L1210 IC50
    39 1
    Compound: mitoxantrone
    Antitumor activity against murine leukemia L1210 cell line.
    Antitumor activity against murine leukemia L1210 cell line.
    		[PMID: 8960558]
    SGC-7901 IC50
    0.293 1
    Compound: Mitoxantrone
    Antiproliferative activity against human SGC7901 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human SGC7901 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 30485090]
    SK-OV-3 IC50
    0.0053 3
    Compound: Mitoxantrone
    Concentration required to inhibit SKOV-3-cell growth by 50%
    Concentration required to inhibit SKOV-3-cell growth by 50%
    		[PMID: 9703471]
    HL-60 IC50
    6.3 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 19615900]
    L1210 IC50
    39 1
    Compound: Mitoxantrone
    Inhibitory activity against resistant murine leukemia L1210 cell lines.
    Inhibitory activity against resistant murine leukemia L1210 cell lines.
    		[PMID: 8648600]
    SK-OV-3 EC50
    0.12 3
    Compound: mitoxantrone
    Antiproliferative activity against human SKOV3 cells after 48 hrs
    Antiproliferative activity against human SKOV3 cells after 48 hrs
    		[PMID: 23395656]
    L1210 IC50
    39 1
    Compound: mitoxantrone
    Tested for inhibitory activity against murine cell line L12110, a strain resistant to doxorubicin using MTT assay.
    Tested for inhibitory activity against murine cell line L12110, a strain resistant to doxorubicin using MTT assay.
    		[PMID: 10956214]
    HL-60 IC50
    6.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 19926279]
    HL-60 IC50
    7.5 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 20951582]
    SK-OV-3 EC50
    0.1207 6
    Compound: Mitoxantrone
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    MCF7 IC50
    41 1
    Compound: mitoxantrone
    Antitumor activity against human mammary carcinoma mitoxantrone-resistant MXF7 breast cell line.
    Antitumor activity against human mammary carcinoma mitoxantrone-resistant MXF7 breast cell line.
    		[PMID: 8960558]
    SK-OV-3 GI50
    11 3
    Compound: Mitoxantrone
    Growth inhibition of human SKOV3 cells by MTT assay
    Growth inhibition of human SKOV3 cells by MTT assay
    		[PMID: 20153184]
    HL-60 IC50
    7.9 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 21458279]
    MCF7 IC50
    41 1
    Compound: Mitoxantrone
    Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
    Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
    		[PMID: 8648600]
    SK-OV-3 IC50
    9.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human SKOV3 cells by MTT assay
    Cytotoxicity against human SKOV3 cells by MTT assay
    		[PMID: 19615900]
    HL-60 IC50
    8.1 3
    Compound: MX
    Cytotoxicity against human HL60 cells after 72 hrs
    Cytotoxicity against human HL60 cells after 72 hrs
    		[PMID: 21354791]
    MCF7 IC50
    41 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line MCF7, a strain resistant to mitoxantrone of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line MCF7, a strain resistant to mitoxantrone of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    U-937 IC50
    6.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human U937 cells by MTT assay
    Cytotoxicity against human U937 cells by MTT assay
    		[PMID: 19615900]
    HL-60 IC50
    8.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
    		[PMID: 21507644]
    L1210 EC50
    >5 6
    Compound: 4
    Effective concentration required to inhibit by 50% the growth of L1210 cells
    Effective concentration required to inhibit by 50% the growth of L1210 cells
    		[PMID: 3172129]
    L1210 IC50
    0.00004 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
    Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
    		[PMID: 9371240]
    UACC-375 IC50
    48 1
    Compound: Mitoxantrone
    Anti-tumor activity against human UACC375 melanoma cell lines by using MTT assay
    Anti-tumor activity against human UACC375 melanoma cell lines by using MTT assay
    		[PMID: 7699715]
    L1210 IC50
    15 3
    Compound: Mitoxantrone
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28222315]
    HL60/MX2 GI50
    26 1
    Compound: MX, mitoxantrone
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    		[PMID: 17962028]
    UACC-375 IC50
    48 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line UA375 of melanoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line UA375 of melanoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HL60/MX2 GI50
    4.42 6
    Compound: mitoxantrone
    Cytotoxicity against human HL60/MX2 cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human HL60/MX2 cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    WiDr IC50
    488 1
    Compound: mitoxantrone
    Tested for inhibitory activity against a multi drug resistant (MDR) strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    Tested for inhibitory activity against a multi drug resistant (MDR) strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    		[PMID: 10956214]
    L1210 IC50
    0.1 3
    Compound: mitoxantrone
    Dose level for 50% inhibition of L1210 cell growth was measured after 24 h.
    Dose level for 50% inhibition of L1210 cell growth was measured after 24 h.
    		[PMID: 3351863]
    HL60/MX2 IC50
    0.561 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    		[PMID: 22944121]
    L1210 IC50
    0.1 3
    Compound: Mitoxantrone
    In vitro cytotoxicity against mouse leukemia L1210 cell lines
    In vitro cytotoxicity against mouse leukemia L1210 cell lines
    		[PMID: 15341949]
    WiDr IC50
    8 1
    Compound: mitoxantrone
    Tested for inhibitory activity against a sensitive strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    Tested for inhibitory activity against a sensitive strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    		[PMID: 10956214]
    HL60/MX2 IC50
    1.51 3
    Compound: MTX, NOVANTRONE
    Cytotoxicity against human HL60/MX2 cells
    Cytotoxicity against human HL60/MX2 cells
    		[PMID: 21439821]
    L1210 IC50
    0.077 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity against murine leukemia cell line L1210
    In vitro cytotoxicity against murine leukemia cell line L1210
    		[PMID: 16169719]
    HL60/MX2 IC50
    1.51 3
    Compound: MX, mitoxantrone
    Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs
    Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs
    		[PMID: 18507368]
    L1210 IC50
    0.002 3
    Compound: Mitoxantrone
    In vitro extracellular concentration required to reduce cell population to 50% against L1210 leukemia cells
    In vitro extracellular concentration required to reduce cell population to 50% against L1210 leukemia cells
    		[PMID: 1573635]
    L1210 IC50
    0.04 3
    Compound: Mitoxantrone
    Inhibitory concentration of compound against proliferation of murine leukemia L1210 cell line
    Inhibitory concentration of compound against proliferation of murine leukemia L1210 cell line
    		[PMID: 12031316]
    HL60/MX2 IC50
    148 1
    Compound: MITO
    Cytotoxicity against human HL60/MX2 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HL60/MX2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28342398]
    L1210 IC50
    0.009 6
    Compound: 1b (mitoxantrone)
    Tested in vitro for inhibitory activity against L1210 murine leukemia
    Tested in vitro for inhibitory activity against L1210 murine leukemia
    		[PMID: 8145234]
    HL60/MX2 IC50
    148 1
    Compound: MITO
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    		[PMID: 29945793]
    HT-1080 IC50
    6.6 x 10-8 41
    Compound: Mitoxantrone
    Inhibitory activity against human tumor cell line HT1080.
    Inhibitory activity against human tumor cell line HT1080.
    		[PMID: 7853345]
    UACC-375 IC50
    48 1
    Compound: mitoxantrone
    Antitumor activity against human melanoma UACC375 cell line.
    Antitumor activity against human melanoma UACC375 cell line.
    		[PMID: 8960558]
    HT-29 GI50
    8.9 3
    Compound: Mitoxantrone
    Growth inhibition of human HT-29 cells by MTT assay
    Growth inhibition of human HT-29 cells by MTT assay
    		[PMID: 20153184]
    UACC-375 IC50
    48 1
    Compound: Mitoxantrone
    Anti-tumor activity against human UACC375 melanoma cell lines by using MTT assay
    Anti-tumor activity against human UACC375 melanoma cell lines by using MTT assay
    		[PMID: 7699715]
    UACC-375 IC50
    48 1
    Compound: Mitoxantrone
    Inhibitory activity against AUC375 cell line
    Inhibitory activity against AUC375 cell line
    		[PMID: 8648600]
    HT-29 IC50
    0.01 3
    Compound: MX
    Concentration required to inhibit cell growth by 50% in vitro against Human colon adenocarcinoma cell line
    Concentration required to inhibit cell growth by 50% in vitro against Human colon adenocarcinoma cell line
    		[PMID: 11563932]
    UACC-375 IC50
    48 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line UA375 of melanoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line UA375 of melanoma using sulforhodamine B assay.
    		[PMID: 10956214]
    HT-29 IC50
    0.01 3
    Compound: Mitoxantrone
    In vitro cytotoxicity was tested against human colon adenocarcinoma HT-29 cell line
    In vitro cytotoxicity was tested against human colon adenocarcinoma HT-29 cell line
    		[PMID: 10411474]
    LoVo IC50
    0.023 6
    Compound: mitoxantrone
    In vitro cytotoxic activity against human colon adenocarcinoma (LoVo) cells
    In vitro cytotoxic activity against human colon adenocarcinoma (LoVo) cells
    		[PMID: 10698460]
    HT-29 IC50
    0.01 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit HT-29 cell growth by 50% after cell drug contact for 144 hrs
    Cytotoxic potency required to inhibit HT-29 cell growth by 50% after cell drug contact for 144 hrs
    		[PMID: 9371240]
    HT-29 IC50
    0.02 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity against colorectal adenocarcinoma HT-29 cells
    In vitro cytotoxicity against colorectal adenocarcinoma HT-29 cells
    		[PMID: 16169719]
    LoVo IC50
    0.62 6
    Compound: mitoxantrone
    In vitro cytotoxic activity against human colon adenocarcinoma resistant to doxorubicin (LoVo Dx) cells.
    In vitro cytotoxic activity against human colon adenocarcinoma resistant to doxorubicin (LoVo Dx) cells.
    		[PMID: 10698460]
    HT-29 IC50
    0.025 3
    Compound: Mx
    Antiproliferative activity against HT29 cells by MTT assay after 72 hrs
    Antiproliferative activity against HT29 cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    LoVo IC50
    0.024 6
    Compound: mitoxantrone
    In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
    In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
    		[PMID: 9876113]
    LoVo IC50
    0.67 6
    Compound: mitoxantrone
    In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
    In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
    		[PMID: 9876113]
    HT-29 IC50
    10 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity is determined as the concentration required to inhibit the growth of human colon adenocarcinoma (HT-29) cell line
    Cytotoxicity is determined as the concentration required to inhibit the growth of human colon adenocarcinoma (HT-29) cell line
    		[PMID: 15456268]
    HT-29 IC50
    10 1
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxic potency against HT-29 (human colon adenocarcinoma) cell line.
    In vitro cytotoxic potency against HT-29 (human colon adenocarcinoma) cell line.
    		[PMID: 11806721]
    LoVo IC50
    0.046 3
    Compound: Mitoxantrone
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo cell line
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo cell line
    		[PMID: 10411474]
    LoVo IC50
    1.29 3
    Compound: Mitoxantrone
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo/Dx resistant cell line
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo/Dx resistant cell line
    		[PMID: 10411474]
    HT-29 IC50
    19.6 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29
    		[PMID: 10479282]
    HT-29 IC50
    2025 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29/Mx
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29/Mx
    		[PMID: 10479282]
    LoVo IC50
    0.25 6
    Compound: 1b (mitoxantrone)
    Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line
    Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line
    		[PMID: 8145234]
    HT-29 IC50
    21.65 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    LoVo IC50
    0.009 6
    Compound: 1b (mitoxantrone)
    Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo)
    Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo)
    		[PMID: 8145234]
    MCF7 GI50
    3.93 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    HT-29 IC50
    8 3
    Compound: Mitoxantrone
    Inhibitory concentration of compound against proliferation of colon carcinoma HT-29 cell line
    Inhibitory concentration of compound against proliferation of colon carcinoma HT-29 cell line
    		[PMID: 12031316]
    HT-29 IC50
    8 3
    Compound: Mitoxantrone
    In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis)
    In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis)
    		[PMID: 12036369]
    MCF7 IC50
    7.1 3
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 19615900]
    MCF7 IC50
    7.1 3
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 21458279]
    HT-29 IC50
    8.7 3
    Compound: Mitoxantrone
    Cytotoxicity against human HT-29 cells by MTT assay
    Cytotoxicity against human HT-29 cells by MTT assay
    		[PMID: 19615900]
    MCF7 IC50
    4 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human mammary carcinoma MCF-7/ADR system.
    In vitro inhibition of tumor cell growth in the human mammary carcinoma MCF-7/ADR system.
    		[PMID: 1447730]
    HT-29 IC50
    1.7 x 10-8 41
    Compound: Mitoxantrone
    Inhibitory activity against human tumor cell line HT-29.
    Inhibitory activity against human tumor cell line HT-29.
    		[PMID: 7853345]
    MCF7 IC50
    0.005 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human mammary tumor MCF-7 system
    In vitro inhibition of tumor cell growth in the human mammary tumor MCF-7 system
    		[PMID: 1447730]
    MCF7 IC50
    72 1
    Compound: mitoxantrone
    Antitumor activity against human mammary carcinoma doxorubicin-resistant MXF7 breast cell line.
    Antitumor activity against human mammary carcinoma doxorubicin-resistant MXF7 breast cell line.
    		[PMID: 8960558]
    MCF7 IC50
    72 1
    Compound: Mitoxantrone
    Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
    Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
    		[PMID: 8648600]
    MCF7 IC50
    72 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line D40, a strain resistant to doxorubicin of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line D40, a strain resistant to doxorubicin of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    MDA-MB-231 IC50
    0.96 3
    Compound: mitoxantrone
    Antiproliferative activity against human MDA-MB-231 cells
    Antiproliferative activity against human MDA-MB-231 cells
    		[PMID: 18296053]
    Cancer cell lines IC50
    75 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human PC3 cancer cell line was determined after 1 hr
    Cytotoxicity against human PC3 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    MDA-MB-231 IC50
    0.96 3
    Compound: mitoxantrone
    Antiproliferative activity against human MDA-MB-231 cells by WST-1 method after 72 hrs
    Antiproliferative activity against human MDA-MB-231 cells by WST-1 method after 72 hrs
    		[PMID: 17335189]
    MDA-MB-231 IC50
    1 3
    Compound: Mitoxantrone
    In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis)
    In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis)
    		[PMID: 12036369]
    MDCK-II IC50
    0.19 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
    		[PMID: 23241029]
    MES-SA IC50
    0.006 3
    Compound: Mit
    Antiproliferative activity against human MES-SA cells after 72 hrs by MTT assay
    Antiproliferative activity against human MES-SA cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    MES-SA IC50
    0.003 3
    Compound: Mx
    Antiproliferative activity against MES-SA cells by MTT assay after 72 hrs
    Antiproliferative activity against MES-SA cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    MES-SA IC50
    0.012 3
    Compound: Mx
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    MES-SA IC50
    0.003 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity against uterine sarcoma MES-SA cells
    In vitro cytotoxicity against uterine sarcoma MES-SA cells
    		[PMID: 16169719]
    MES-SA IC50
    0.03 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity variant MES-SA/Dx5 multidrug resistant cells
    In vitro cytotoxicity variant MES-SA/Dx5 multidrug resistant cells
    		[PMID: 16169719]
    MES-SA/Dx5 IC50
    0.028 3
    Compound: Mx
    Antiproliferative activity against doxorubicin-resistant MES-SA/Dx5 cells by MTT assay after 72 hrs
    Antiproliferative activity against doxorubicin-resistant MES-SA/Dx5 cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    MES-SA/Dx5 IC50
    0.073 3
    Compound: Mit
    Antiproliferative activity against human MES-SA/Dx5 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MES-SA/Dx5 cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    MES-SA/Dx5 IC50
    0.08 3
    Compound: Mx
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    HaCaT IC50
    3.9 3
    Compound: Mitoxantrone
    Cytotoxicity against human HaCaT cells by Cell titre-blue assay
    Cytotoxicity against human HaCaT cells by Cell titre-blue assay
    		[PMID: 26684177]
    MKN-28 IC50
    0.02 6
    Compound: mitoxantrone
    Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
    Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    HCT-116 IC50
    110 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human HCT116 cancer cell line was determined after 1 hr
    Cytotoxicity against human HCT116 cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    A-375 IC50
    111.5 1
    Compound: Mitoxantrone
    Cytotoxicity against human A375 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human A375 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    HeLa EC50
    0.55 6
    Compound: 4
    Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
    Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
    		[PMID: 3172129]
    HeLa IC50
    0.04 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth
    		[PMID: 35931243]
    Bel-7402 IC50
    116.6 1
    Compound: Mitoxantrone
    Cytotoxicity against human Bel7402 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human Bel7402 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    HeLa IC50
    0.044 3
    Compound: Mit
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    K562 IC50
    133.5 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 hr exposure to compound)
    		[PMID: 10479282]
    HeLa IC50
    2.35 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    HL60/MX2 IC50
    148 1
    Compound: MITO
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    Antiproliferative activity against human HL60/MX2 cells after 72 hrs by SRB assay
    		[PMID: 29945793]
    HL60/MX2 IC50
    148 1
    Compound: MITO
    Cytotoxicity against human HL60/MX2 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HL60/MX2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28342398]
    HeLa IC50
    < 0.1 3
    Compound: mitoxantrone
    Cytotoxicity against human HeLa cells expressing telomerase after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells expressing telomerase after 96 hrs by MTT assay
    		[PMID: 18754611]
    H22 IC50
    187 1
    Compound: Mitoxantrone
    Dark toxicity against mouse H22 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Dark toxicity against mouse H22 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    P388/ADR IC50
    194 1
    Compound: Mitoxantrone
    Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    		[PMID: 17154505]
    N592 IC50
    0.02 3
    Compound: Mitoxantrone
    Cytotoxicity against human small-cell lung cancer (SCLC)
    Cytotoxicity against human small-cell lung cancer (SCLC)
    		[PMID: 8258835]
    HepG2 IC50
    11.05 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 24794747]
    HepG2 IC50
    15.33 3
    Compound: MTZ
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33191085]
    NCI-H460 EC50
    0.12 3
    Compound: mitoxantrone
    Antiproliferative activity against human NCI-H460 cells after 48 hrs
    Antiproliferative activity against human NCI-H460 cells after 48 hrs
    		[PMID: 23395656]
    HepG2 IC50
    18.6 3
    Compound: Mitoxantrone
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    NCI-H460 EC50
    0.1224 6
    Compound: Mitoxantrone
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    NCI-H460 EC50
    0.03 3
    Compound: Mitoxantrone
    Cytotoxicity against human NCI-H460 cells after 48 hrs by resazurin dye assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by resazurin dye assay
    		[PMID: 23988351]
    NCI-H460 GI50
    1.29 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    NCI-H460 IC50
    0.36 3
    Compound: MX
    Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 2 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 2 hrs by MTT assay
    		[PMID: 31302589]
    Ishikawa IC50
    0.01 3
    Compound: Mit
    Antiproliferative activity against human Ishikawa cells after 72 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    NIH3T3 IC50
    42 3
    Compound: Mitoxantrone
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28222315]
    MCF7 IC50
    380.2 1
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    P388 IC50
    27.56 3
    Compound: mitoxantrone
    Relative cytotoxicity against Human bone marrow samples; Value is in range, activity expressed as IC50
    Relative cytotoxicity against Human bone marrow samples; Value is in range, activity expressed as IC50
    		[PMID: 10377219]
    K562 IC50
    0.0026 3
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    		[PMID: 18076140]
    P388/ADR IC50
    395 1
    Compound: Mitoxantrone
    Antiproliferative activity against adriamycin resistant P388 cells by ELISA
    Antiproliferative activity against adriamycin resistant P388 cells by ELISA
    		[PMID: 17154505]
    LoVo IC50
    461 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo/Dx(RI)
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo/Dx(RI)
    		[PMID: 10479282]
    K562 IC50
    0.0334 6
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    WiDr IC50
    488 1
    Compound: mitoxantrone
    Activity against human colon carcinoma multi drug resistant (MDR)-WiDr cell line.
    Activity against human colon carcinoma multi drug resistant (MDR)-WiDr cell line.
    		[PMID: 8960558]
    K562 IC50
    0.14 3
    Compound: Mitoxantrone
    Antiproliferative activity against human K562 cells assessed as inhibition of cell growth
    Antiproliferative activity against human K562 cells assessed as inhibition of cell growth
    		[PMID: 35931243]
    WiDr IC50
    488 1
    Compound: Mitoxantrone
    Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
    Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
    		[PMID: 8648600]
    K562 IC50
    0.42 3
    Compound: Mitoxantrone
    Growth inhibition of human K562 cells after 72 hrs by MTS method
    Growth inhibition of human K562 cells after 72 hrs by MTS method
    		[PMID: 18258442]
    K562 IC50
    0.51 3
    Compound: mitoxantrone
    Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay
    		[PMID: 22582991]
    PC-3 GI50
    0.78 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    K562 IC50
    133.5 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (RI) (72 hr exposure to compound)
    		[PMID: 10479282]
    WiDr IC50
    488 1
    Compound: mitoxantrone
    Tested for inhibitory activity against a multi drug resistant (MDR) strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    Tested for inhibitory activity against a multi drug resistant (MDR) strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    		[PMID: 10956214]
    K562 IC50
    2.35 3
    Compound: MTZ
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33191085]
    PC-3 IC50
    0.29 3
    Compound: Mitoxantrone
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 22100139]
    MDA-MB-435 IC50
    646 1
    Compound: Mitoxantrone
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    		[PMID: 17154505]
    K562 IC50
    2 6
    Compound: mitoxanthrone
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 12027731]
    K562 IC50
    4.55 3
    Compound: Mitoxantrone
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 29407981]
    RPMI-8226 IC50
    0.03 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human myeloma 8226 system.
    In vitro inhibition of tumor cell growth in the human myeloma 8226 system.
    		[PMID: 1447730]
    K562 IC50
    7.06 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against MDR cell line K562R (72 hr exposure to compound)
    		[PMID: 10479282]
    RPMI-8226 IC50
    0.18 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human myeloma 8226/ADR system.
    In vitro inhibition of tumor cell growth in the human myeloma 8226/ADR system.
    		[PMID: 1447730]
    SCLC IC50
    0.03 3
    Compound: Mitoxantrone
    Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP)
    Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP)
    		[PMID: 8258835]
    KB EC50
    0.355 6
    Compound: Mitoxantrone
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    KB EC50
    0.36 3
    Compound: mitoxantrone
    Antiproliferative activity against human KB/HeLa cells after 48 hrs
    Antiproliferative activity against human KB/HeLa cells after 48 hrs
    		[PMID: 23395656]
    SF-268 EC50
    0.32 3
    Compound: mitoxantrone
    Antiproliferative activity against human SF268 cells after 48 hrs
    Antiproliferative activity against human SF268 cells after 48 hrs
    		[PMID: 23395656]
    KB EC50
    0.42 3
    Compound: Mitoxantrone
    Cytotoxicity against human KB/HeLa cells after 48 hrs by resazurin dye assay
    Cytotoxicity against human KB/HeLa cells after 48 hrs by resazurin dye assay
    		[PMID: 23988351]
    SF-268 EC50
    0.315 6
    Compound: Mitoxantrone
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    SF-268 GI50
    0.97 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
    Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    L1210 EC50
    > 5 6
    Compound: 4
    Effective concentration required to inhibit by 50% the growth of L1210 cells
    Effective concentration required to inhibit by 50% the growth of L1210 cells
    		[PMID: 3172129]
    WiDr IC50
    1400 1
    Compound: Mitoxantrone
    Activity against resistant cell line of WiDr human colon tumor
    Activity against resistant cell line of WiDr human colon tumor
    		[PMID: 7699715]
    L1210 IC50
    0.002 3
    Compound: Mitoxantrone
    In vitro extracellular concentration required to reduce cell population to 50% against L1210 leukemia cells
    In vitro extracellular concentration required to reduce cell population to 50% against L1210 leukemia cells
    		[PMID: 1573635]
    MDA-MB-435 IC50
    1442 1
    Compound: Mitoxantrone
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA
    		[PMID: 17154505]
    L1210 IC50
    0.009 6
    Compound: 1b (mitoxantrone)
    Tested in vitro for inhibitory activity against L1210 murine leukemia
    Tested in vitro for inhibitory activity against L1210 murine leukemia
    		[PMID: 8145234]
    L1210 IC50
    0.04 3
    Compound: Mitoxantrone
    Inhibitory concentration of compound against proliferation of murine leukemia L1210 cell line
    Inhibitory concentration of compound against proliferation of murine leukemia L1210 cell line
    		[PMID: 12031316]
    HT-29 IC50
    2025 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29/Mx
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29/Mx
    		[PMID: 10479282]
    L1210 IC50
    0.077 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity against murine leukemia cell line L1210
    In vitro cytotoxicity against murine leukemia cell line L1210
    		[PMID: 16169719]
    SK-BR-3 IC50
    0.016 3
    Compound: Mitoxantrone
    The IC50 value was measured on human breast cancer cell line SK-BR-3.
    The IC50 value was measured on human breast cancer cell line SK-BR-3.
    		[PMID: 7699696]
    L1210 IC50
    0.1 3
    Compound: Mitoxantrone
    In vitro cytotoxicity against mouse leukemia L1210 cell lines
    In vitro cytotoxicity against mouse leukemia L1210 cell lines
    		[PMID: 15341949]
    SK-OV-3 EC50
    0.12 3
    Compound: mitoxantrone
    Antiproliferative activity against human SKOV3 cells after 48 hrs
    Antiproliferative activity against human SKOV3 cells after 48 hrs
    		[PMID: 23395656]
    SK-OV-3 EC50
    0.1207 6
    Compound: Mitoxantrone
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    L1210 IC50
    0.1 3
    Compound: mitoxantrone
    Dose level for 50% inhibition of L1210 cell growth was measured after 24 h.
    Dose level for 50% inhibition of L1210 cell growth was measured after 24 h.
    		[PMID: 3351863]
    L1210 IC50
    0.1 3
    Compound: mitoxantrone
    Dose level for 50% inhibition of L1210 cell growth was measured after 48 hr.
    Dose level for 50% inhibition of L1210 cell growth was measured after 48 hr.
    		[PMID: 3351863]
    SK-OV-3 GI50
    11 3
    Compound: Mitoxantrone
    Growth inhibition of human SKOV3 cells by MTT assay
    Growth inhibition of human SKOV3 cells by MTT assay
    		[PMID: 20153184]
    SK-OV-3 IC50
    0.0053 3
    Compound: Mitoxantrone
    Compound was evaluated for cytotoxicity against SCOV-3 cell lines.
    Compound was evaluated for cytotoxicity against SCOV-3 cell lines.
    		10.1016/0960-894X(96)00130-8
    L1210 IC50
    10 1
    Compound: mitoxantrone
    Tested for inhibitory activity against murine cell line L12110, a strain sensitive to doxorubicin using MTT assay.
    Tested for inhibitory activity against murine cell line L12110, a strain sensitive to doxorubicin using MTT assay.
    		[PMID: 10956214]
    L1210 IC50
    11.4 1
    Compound: Mitoxantrone
    Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 hr exposure to compound)
    Compound was tested in vitro for cytotoxicity against L1210 murine cell line (48 hr exposure to compound)
    		[PMID: 10479282]
    SK-OV-3 IC50
    0.0053 3
    Compound: Mitoxantrone
    Concentration required to inhibit SKOV-3-cell growth by 50%
    Concentration required to inhibit SKOV-3-cell growth by 50%
    		[PMID: 9703471]
    SK-OV-3 IC50
    0.0053 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit SKOV-3 cell growth 50%
    Cytotoxic potency required to inhibit SKOV-3 cell growth 50%
    		[PMID: 9371240]
    L1210 IC50
    15 3
    Compound: Mitoxantrone
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28222315]
    L1210 IC50
    21 1
    Compound: Mitoxantrone
    An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
    An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
    		[PMID: 8648600]
    SK-OV-3 IC50
    9.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human SKOV3 cells by MTT assay
    Cytotoxicity against human SKOV3 cells by MTT assay
    		[PMID: 19615900]
    L1210 IC50
    39 1
    Compound: Mitoxantrone
    Antitumor activity against murine L1210 resistant cell line by using MTT assay
    Antitumor activity against murine L1210 resistant cell line by using MTT assay
    		[PMID: 7699715]
    T cell line IC50
    23.1 3
    Compound: 202a; MTX
    Antiviral activity against HIV-1 infected in human T cell line assessed as inhibition of DNA replication
    Antiviral activity against HIV-1 infected in human T cell line assessed as inhibition of DNA replication
    		[PMID: 34060847]
    U-937 IC50
    6.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human U937 cells by MTT assay
    Cytotoxicity against human U937 cells by MTT assay
    		[PMID: 19615900]
    L1210 IC50
    39 1
    Compound: Mitoxantrone
    Inhibitory activity against resistant murine leukemia L1210 cell lines.
    Inhibitory activity against resistant murine leukemia L1210 cell lines.
    		[PMID: 8648600]
    L1210 IC50
    39 1
    Compound: mitoxantrone
    Tested for inhibitory activity against murine cell line L12110, a strain resistant to doxorubicin using MTT assay.
    Tested for inhibitory activity against murine cell line L12110, a strain resistant to doxorubicin using MTT assay.
    		[PMID: 10956214]
    CCD 19Lu IC50
    >160 1
    Compound: Mitoxantrone
    Cytotoxicity in human CCD-19Lu cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity in human CCD-19Lu cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 30108778]
    L1210 IC50
    39 1
    Compound: mitoxantrone
    Antitumor activity against murine leukemia L1210 cell line.
    Antitumor activity against murine leukemia L1210 cell line.
    		[PMID: 8960558]
    XRS6 IC50
    0.01 3
    Compound: mitoxantrone
    Cytotoxicity against CHO cell line xrs6
    Cytotoxicity against CHO cell line xrs6
    		[PMID: 7473578]
    L1210 IC50
    5 1
    Compound: Mitoxantrone
    Anti-tumor activity against murine L1210 sensitive cell line by using MTT assay
    Anti-tumor activity against murine L1210 sensitive cell line by using MTT assay
    		[PMID: 7699715]
    L1210 IC50
    9.7 1
    Compound: Mitoxantrone
    Inhibitory activity against sensitive L1210 cell lines
    Inhibitory activity against sensitive L1210 cell lines
    		[PMID: 8648600]
    L1210 IC50
    9.7 1
    Compound: mitoxantrone
    Antitumor activity against sensitive L1210 murine leukemia cell lines.
    Antitumor activity against sensitive L1210 murine leukemia cell lines.
    		[PMID: 8960558]
    L1210 IC50
    1.6 x 10-9 41
    Compound: 1
    In vitro for its inhibitory activity against murine L1210 leukemia
    In vitro for its inhibitory activity against murine L1210 leukemia
    		[PMID: 3397990]
    L1210 IC50
    1.6 x 10-9 41
    Compound: 5 (mitoxantrone)
    Tested in vitro against murine L1210 leukemia.
    Tested in vitro against murine L1210 leukemia.
    		[PMID: 3806589]
    L1210 IC50
    uM 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
    Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
    		[PMID: 9371240]
    LoVo IC50
    0.009 6
    Compound: 1b (mitoxantrone)
    Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo)
    Tested in vitro for cytotoxic activity against Human colon Adenocarcinoma sensitive cell line (LoVo)
    		[PMID: 8145234]
    LoVo IC50
    0.023 6
    Compound: mitoxantrone
    In vitro cytotoxic activity against human colon adenocarcinoma (LoVo) cells
    In vitro cytotoxic activity against human colon adenocarcinoma (LoVo) cells
    		[PMID: 10698460]
    LoVo IC50
    0.024 6
    Compound: mitoxantrone
    In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
    In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
    		[PMID: 9876113]
    LoVo IC50
    0.046 3
    Compound: Mitoxantrone
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo cell line
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo cell line
    		[PMID: 10411474]
    LoVo IC50
    0.25 6
    Compound: 1b (mitoxantrone)
    Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line
    Tested in vitro for cytotoxic activity against Doxorubicin resistant Human colon Adenocarcinoma sensitive cell line
    		[PMID: 8145234]
    LoVo IC50
    0.62 6
    Compound: mitoxantrone
    In vitro cytotoxic activity against human colon adenocarcinoma resistant to doxorubicin (LoVo Dx) cells.
    In vitro cytotoxic activity against human colon adenocarcinoma resistant to doxorubicin (LoVo Dx) cells.
    		[PMID: 10698460]
    LoVo IC50
    0.67 6
    Compound: mitoxantrone
    In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
    In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
    		[PMID: 9876113]
    LoVo IC50
    1.29 3
    Compound: Mitoxantrone
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo/Dx resistant cell line
    In vitro cytotoxicity was tested against human colon adenocarcinoma LoVo/Dx resistant cell line
    		[PMID: 10411474]
    LoVo IC50
    12 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human LoVo cancer cell line was determined after 1 hr
    Cytotoxicity against human LoVo cancer cell line was determined after 1 hr
    		[PMID: 15456268]
    LoVo IC50
    17.1 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo
    		[PMID: 10479282]
    LoVo IC50
    3.3 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human LoVo cancer cell line was determined after 144 hr
    Cytotoxicity against human LoVo cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    LoVo IC50
    461 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo/Dx(RI)
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line LoVo/Dx(RI)
    		[PMID: 10479282]
    LoVo IC50
    9.7 x 10-9 41
    Compound: Mitoxantrone
    Inhibitory activity against human colon adenocarcinoma cell line LoVo.
    Inhibitory activity against human colon adenocarcinoma cell line LoVo.
    		[PMID: 7853345]
    LoVo IC50
    5.3 x 10-7 41
    Compound: Mitoxantrone
    Inhibitory activity against human colon adenocarcinoma cell line LoVo/Dx.
    Inhibitory activity against human colon adenocarcinoma cell line LoVo/Dx.
    		[PMID: 7853345]
    MCF7 GI50
    3.93 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    MCF7 IC50
    0.005 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human mammary tumor MCF-7 system
    In vitro inhibition of tumor cell growth in the human mammary tumor MCF-7 system
    		[PMID: 1447730]
    MCF7 IC50
    26 1
    Compound: mitoxantrone
    Cytotoxicity against human MCF7 cells
    Cytotoxicity against human MCF7 cells
    		[PMID: 25811651]
    MCF7 IC50
    380.2 1
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and measured after 48 hrs by CCK8 assay
    		[PMID: 30925340]
    MCF7 IC50
    4 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human mammary carcinoma MCF-7/ADR system.
    In vitro inhibition of tumor cell growth in the human mammary carcinoma MCF-7/ADR system.
    		[PMID: 1447730]
    MCF7 IC50
    41 1
    Compound: Mitoxantrone
    Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
    Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
    		[PMID: 8648600]
    MCF7 IC50
    41 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line MCF7, a strain resistant to mitoxantrone of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line MCF7, a strain resistant to mitoxantrone of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    MCF7 IC50
    41 1
    Compound: mitoxantrone
    Antitumor activity against human mammary carcinoma mitoxantrone-resistant MXF7 breast cell line.
    Antitumor activity against human mammary carcinoma mitoxantrone-resistant MXF7 breast cell line.
    		[PMID: 8960558]
    MCF7 IC50
    7.1 3
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 19615900]
    MCF7 IC50
    7.1 3
    Compound: Mitoxantrone
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 21458279]
    MCF7 IC50
    72 1
    Compound: Mitoxantrone
    Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
    Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
    		[PMID: 8648600]
    MCF7 IC50
    72 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line D40, a strain resistant to doxorubicin of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line D40, a strain resistant to doxorubicin of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    MCF7 IC50
    72 1
    Compound: mitoxantrone
    Antitumor activity against human mammary carcinoma doxorubicin-resistant MXF7 breast cell line.
    Antitumor activity against human mammary carcinoma doxorubicin-resistant MXF7 breast cell line.
    		[PMID: 8960558]
    MCF7 IC50
    8.7 1
    Compound: Mitoxantrone
    Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
    Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
    		[PMID: 8648600]
    MCF7 IC50
    8.7 1
    Compound: mitoxantrone
    Antitumor activity against human mammary carcinoma sensitive MXF7 breast cell line.
    Antitumor activity against human mammary carcinoma sensitive MXF7 breast cell line.
    		[PMID: 8960558]
    MCF7 IC50
    9 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line MCF7, a strain sensitive to doxorubicin of breast carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line MCF7, a strain sensitive to doxorubicin of breast carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    MCF7 IC50
    2.0 x 10-8 41
    Compound: Mitoxantrone
    Inhibitory activity against human tumor cell line MCF-7 breast adenocarcinoma.
    Inhibitory activity against human tumor cell line MCF-7 breast adenocarcinoma.
    		[PMID: 7853345]
    MDA-MB-231 IC50
    0.96 3
    Compound: mitoxantrone
    Antiproliferative activity against human MDA-MB-231 cells by WST-1 method after 72 hrs
    Antiproliferative activity against human MDA-MB-231 cells by WST-1 method after 72 hrs
    		[PMID: 17335189]
    MDA-MB-231 IC50
    0.96 3
    Compound: mitoxantrone
    Antiproliferative activity against human MDA-MB-231 cells
    Antiproliferative activity against human MDA-MB-231 cells
    		[PMID: 18296053]
    MDA-MB-231 IC50
    1 3
    Compound: Mitoxantrone
    In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis)
    In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis)
    		[PMID: 12036369]
    MDA-MB-435 IC50
    0.35 1
    Compound: Mitoxantrone
    Antiproliferative activity against MDA435/LCC6 cells by ELISA
    Antiproliferative activity against MDA435/LCC6 cells by ELISA
    		[PMID: 17154505]
    MDA-MB-435 IC50
    1442 1
    Compound: Mitoxantrone
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA
    		[PMID: 17154505]
    MDA-MB-435 IC50
    646 1
    Compound: Mitoxantrone
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    		[PMID: 17154505]
    MDCK-II IC50
    0.19 3
    Compound: mitoxantrone
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
    Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
    		[PMID: 23241029]
    MES-SA IC50
    0.003 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity against uterine sarcoma MES-SA cells
    In vitro cytotoxicity against uterine sarcoma MES-SA cells
    		[PMID: 16169719]
    MES-SA IC50
    0.003 3
    Compound: Mx
    Antiproliferative activity against MES-SA cells by MTT assay after 72 hrs
    Antiproliferative activity against MES-SA cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    MES-SA IC50
    0.006 3
    Compound: Mit
    Antiproliferative activity against human MES-SA cells after 72 hrs by MTT assay
    Antiproliferative activity against human MES-SA cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    MES-SA IC50
    0.012 3
    Compound: Mx
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    MES-SA IC50
    0.03 3
    Compound: Mitoxantrone (Mx)
    In vitro cytotoxicity variant MES-SA/Dx5 multidrug resistant cells
    In vitro cytotoxicity variant MES-SA/Dx5 multidrug resistant cells
    		[PMID: 16169719]
    MES-SA/Dx5 IC50
    0.028 3
    Compound: Mx
    Antiproliferative activity against doxorubicin-resistant MES-SA/Dx5 cells by MTT assay after 72 hrs
    Antiproliferative activity against doxorubicin-resistant MES-SA/Dx5 cells by MTT assay after 72 hrs
    		[PMID: 16824751]
    MES-SA/Dx5 IC50
    0.073 3
    Compound: Mit
    Antiproliferative activity against human MES-SA/Dx5 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MES-SA/Dx5 cells after 72 hrs by MTT assay
    		[PMID: 25998504]
    MES-SA/Dx5 IC50
    0.08 3
    Compound: Mx
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 21444205]
    MKN-28 IC50
    0.02 6
    Compound: mitoxantrone
    Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
    Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay
    		[PMID: 10843567]
    MKN-45 IC50
    12 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human MKN45 cancer cell line was determined after 144 hr
    Cytotoxicity against human MKN45 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    N592 IC50
    0.02 3
    Compound: Mitoxantrone
    Cytotoxicity against human small-cell lung cancer (SCLC)
    Cytotoxicity against human small-cell lung cancer (SCLC)
    		[PMID: 8258835]
    NCI-H460 EC50
    0.03 3
    Compound: Mitoxantrone
    Cytotoxicity against human NCI-H460 cells after 48 hrs by resazurin dye assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by resazurin dye assay
    		[PMID: 23988351]
    NCI-H460 EC50
    0.12 3
    Compound: mitoxantrone
    Antiproliferative activity against human NCI-H460 cells after 48 hrs
    Antiproliferative activity against human NCI-H460 cells after 48 hrs
    		[PMID: 23395656]
    NCI-H460 EC50
    0.1224 6
    Compound: Mitoxantrone
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    NCI-H460 GI50
    1.29 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    NCI-H460 IC50
    0.36 3
    Compound: MX
    Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 2 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 2 hrs by MTT assay
    		[PMID: 31302589]
    NIH3T3 IC50
    42 3
    Compound: Mitoxantrone
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28222315]
    OVCAR-3 IC50
    5.8 1
    Compound: Mitoxantrone
    Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay
    Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay
    		[PMID: 7699715]
    OVCAR-3 IC50
    5.8 1
    Compound: Mitoxantrone
    Inhibitory activity against OVCAR-3 cell line
    Inhibitory activity against OVCAR-3 cell line
    		[PMID: 8648600]
    OVCAR-3 IC50
    5.8 1
    Compound: mitoxantrone
    Antitumor activity against human ovarian OVCAR-3 cell lines.
    Antitumor activity against human ovarian OVCAR-3 cell lines.
    		[PMID: 8960558]
    OVCAR-3 IC50
    6 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line OVCAR-3, a resistant ovarian carcinoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line OVCAR-3, a resistant ovarian carcinoma using sulforhodamine B assay.
    		[PMID: 10956214]
    P388 IC50
    27.56 3
    Compound: mitoxantrone
    Relative cytotoxicity against Human bone marrow samples; Value is in range, activity expressed as IC50
    Relative cytotoxicity against Human bone marrow samples; Value is in range, activity expressed as IC50
    		[PMID: 10377219]
    P388 IC50
    4.3 1
    Compound: Mitoxantrone
    Antiproliferative activity against P388 cells by ELISA
    Antiproliferative activity against P388 cells by ELISA
    		[PMID: 17154505]
    P388/ADR IC50
    194 1
    Compound: Mitoxantrone
    Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA
    		[PMID: 17154505]
    P388/ADR IC50
    395 1
    Compound: Mitoxantrone
    Antiproliferative activity against adriamycin resistant P388 cells by ELISA
    Antiproliferative activity against adriamycin resistant P388 cells by ELISA
    		[PMID: 17154505]
    PC-3 GI50
    0.78 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    PC-3 IC50
    0.29 3
    Compound: Mitoxantrone
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
    		[PMID: 22100139]
    PC-3 IC50
    7 1
    Compound: MX (Mitoxantrone)
    Cytotoxicity against human PC3 cancer cell line was determined after 144 hr
    Cytotoxicity against human PC3 cancer cell line was determined after 144 hr
    		[PMID: 15456268]
    PC-3 IC50
    7.1 1
    Compound: Mitoxantrone
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line PC3
    In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line PC3
    		[PMID: 10479282]
    RPMI-8226 IC50
    0.03 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human myeloma 8226 system.
    In vitro inhibition of tumor cell growth in the human myeloma 8226 system.
    		[PMID: 1447730]
    RPMI-8226 IC50
    0.18 3
    Compound: MTXN
    In vitro inhibition of tumor cell growth in the human myeloma 8226/ADR system.
    In vitro inhibition of tumor cell growth in the human myeloma 8226/ADR system.
    		[PMID: 1447730]
    SCLC IC50
    0.03 3
    Compound: Mitoxantrone
    Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP)
    Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP)
    		[PMID: 8258835]
    SF-268 EC50
    0.315 6
    Compound: Mitoxantrone
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    SF-268 EC50
    0.32 3
    Compound: mitoxantrone
    Antiproliferative activity against human SF268 cells after 48 hrs
    Antiproliferative activity against human SF268 cells after 48 hrs
    		[PMID: 23395656]
    SF-268 GI50
    0.97 3
    Compound: MX, mitoxantrone
    Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
    Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
    		[PMID: 17962028]
    SGC-7901 IC50
    0.293 1
    Compound: Mitoxantrone
    Antiproliferative activity against human SGC7901 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human SGC7901 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 30485090]
    SK-BR-3 IC50
    0.016 3
    Compound: Mitoxantrone
    The IC50 value was measured on human breast cancer cell line SK-BR-3.
    The IC50 value was measured on human breast cancer cell line SK-BR-3.
    		[PMID: 7699696]
    SK-OV-3 EC50
    0.12 3
    Compound: mitoxantrone
    Antiproliferative activity against human SKOV3 cells after 48 hrs
    Antiproliferative activity against human SKOV3 cells after 48 hrs
    		[PMID: 23395656]
    SK-OV-3 EC50
    0.1207 6
    Compound: Mitoxantrone
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay
    		[PMID: 21458262]
    SK-OV-3 GI50
    11 3
    Compound: Mitoxantrone
    Growth inhibition of human SKOV3 cells by MTT assay
    Growth inhibition of human SKOV3 cells by MTT assay
    		[PMID: 20153184]
    SK-OV-3 IC50
    0.0053 3
    Compound: Mitoxantrone
    Compound was evaluated for cytotoxicity against SCOV-3 cell lines.
    Compound was evaluated for cytotoxicity against SCOV-3 cell lines.
    		10.1016/0960-894X(96)00130-8
    SK-OV-3 IC50
    0.0053 3
    Compound: Mitoxantrone
    Concentration required to inhibit SKOV-3-cell growth by 50%
    Concentration required to inhibit SKOV-3-cell growth by 50%
    		[PMID: 9703471]
    SK-OV-3 IC50
    0.0053 3
    Compound: mitoxantrone
    Cytotoxic potency required to inhibit SKOV-3 cell growth 50%
    Cytotoxic potency required to inhibit SKOV-3 cell growth 50%
    		[PMID: 9371240]
    SK-OV-3 IC50
    9.8 3
    Compound: Mitoxantrone
    Cytotoxicity against human SKOV3 cells by MTT assay
    Cytotoxicity against human SKOV3 cells by MTT assay
    		[PMID: 19615900]
    T cell line IC50
    23.1 3
    Compound: 202a; MTX
    Antiviral activity against HIV-1 infected in human T cell line assessed as inhibition of DNA replication
    Antiviral activity against HIV-1 infected in human T cell line assessed as inhibition of DNA replication
    		[PMID: 34060847]
    U-937 IC50
    6.2 3
    Compound: Mitoxantrone
    Cytotoxicity against human U937 cells by MTT assay
    Cytotoxicity against human U937 cells by MTT assay
    		[PMID: 19615900]
    UACC-375 IC50
    48 1
    Compound: Mitoxantrone
    Anti-tumor activity against human UACC375 melanoma cell lines by using MTT assay
    Anti-tumor activity against human UACC375 melanoma cell lines by using MTT assay
    		[PMID: 7699715]
    UACC-375 IC50
    48 1
    Compound: Mitoxantrone
    Inhibitory activity against AUC375 cell line
    Inhibitory activity against AUC375 cell line
    		[PMID: 8648600]
    UACC-375 IC50
    48 1
    Compound: mitoxantrone
    Tested for inhibitory activity against human tumor cell line UA375 of melanoma using sulforhodamine B assay.
    Tested for inhibitory activity against human tumor cell line UA375 of melanoma using sulforhodamine B assay.
    		[PMID: 10956214]
    UACC-375 IC50
    48 1
    Compound: mitoxantrone
    Antitumor activity against human melanoma UACC375 cell line.
    Antitumor activity against human melanoma UACC375 cell line.
    		[PMID: 8960558]
    WiDr IC50
    10 1
    Compound: Mitoxantrone
    Activity against sensitive cell line of WiDr human colon tumor
    Activity against sensitive cell line of WiDr human colon tumor
    		[PMID: 7699715]
    WiDr IC50
    1400 1
    Compound: Mitoxantrone
    Activity against resistant cell line of WiDr human colon tumor
    Activity against resistant cell line of WiDr human colon tumor
    		[PMID: 7699715]
    WiDr IC50
    488 1
    Compound: Mitoxantrone
    Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
    Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
    		[PMID: 8648600]
    WiDr IC50
    488 1
    Compound: mitoxantrone
    Tested for inhibitory activity against a multi drug resistant (MDR) strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    Tested for inhibitory activity against a multi drug resistant (MDR) strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    		[PMID: 10956214]
    WiDr IC50
    488 1
    Compound: mitoxantrone
    Activity against human colon carcinoma multi drug resistant (MDR)-WiDr cell line.
    Activity against human colon carcinoma multi drug resistant (MDR)-WiDr cell line.
    		[PMID: 8960558]
    WiDr IC50
    8 1
    Compound: mitoxantrone
    Tested for inhibitory activity against a sensitive strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    Tested for inhibitory activity against a sensitive strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
    		[PMID: 10956214]
    WiDr IC50
    8.1 1
    Compound: Mitoxantrone
    Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
    Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
    		[PMID: 8648600]
    WiDr IC50
    8.1 1
    Compound: mitoxantrone
    Activity against human colon carcinoma sensitive WiDr cell line.
    Activity against human colon carcinoma sensitive WiDr cell line.
    		[PMID: 8960558]
    XRS6 IC50
    0.01 3
    Compound: mitoxantrone
    Cytotoxicity against CHO cell line xrs6
    Cytotoxicity against CHO cell line xrs6
    		[PMID: 7473578]
    In Vitro

    Mitoxantrone inhibits PKC in a competitive manner with respect to histone H1, and its Ki value is 6.3 μM and in a non-competitive manner with respect to phosphatidylserine and ATP[1].
    Mitoxantrone (0.5 μg/mL, 48 h) induces a decrease in B-CLL cells. Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), demonstrating that the cytotoxic effect of Mitoxantrone is due to induction of apoptosis[2].
    Mitoxantrone shows cytotoxicity to human breast carcinoma cell lines MDA-MB-231 and MCF-7 with IC50 values of 18 and 196 nM, respectively[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Mitoxantrone Related Antibodies
    In Vivo

    Mitoxantrone (IP, 0-3.2 mg/kg/day) produces a statistically significant number of 60-day survivors at 1.6 mg/kg in mice with IP implanted L1210 leukemia[4].
    Mitoxantrone (IV, 0-3.2 mg/kg/day) shows effective antitumor activities and produces a 60% ILS (increase in lifespan) at 3.2 mg/kg in SC implanted Lewis lung carcinoma[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    444.48

    Formula

    C22H28N4O6
    CAS No.
    Appearance

    Solid

    Color

    Dark blue to black

    SMILES

    O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 35 mg/mL (78.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2498 mL 11.2491 mL 22.4982 mL
    5 mM 0.4500 mL 2.2498 mL 4.4996 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.58%

    SDS (394 KB)

    COA (251 KB) HNMR (425 KB) RP-HPLC (266 KB) LCMS (133 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [3]

    The human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded in standard 96-well plates. One day after seeding, the culture medium is changed and replaced by medium containing different concentration of Mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) during 7 days. Viability of cells are measured as a whole by the tetrazolium salt assay[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [4]

    Mice: Mitoxantrone is tested for antitumor activity against experimental tumors in mice and the results are compared with those of seven antitumor antibiotics. The drugs are given IP or IV, in general on days 1, 5, and 9 following tumor inoculation. Mitoxantrone is given IP at the optimal dose (1.6 mg/kg/day; as a free base)[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2498 mL 11.2491 mL 22.4982 mL 56.2455 mL
    5 mM 0.4500 mL 2.2498 mL 4.4996 mL 11.2491 mL
    10 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
    15 mM 0.1500 mL 0.7499 mL 1.4999 mL 3.7497 mL
    20 mM 0.1125 mL 0.5625 mL 1.1249 mL 2.8123 mL
    25 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
    30 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
    40 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4061 mL
    50 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
    60 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9374 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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