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potassium-deuteroxide-99-5-d-40-wt-in-d2o

" in MedChemExpress (MCE) Product Catalog:

100

Inhibitors & Agonists

1

Fluorescent Dyes

6

Biochemical Assay Reagents

21

Peptides

14

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0219
    Bicuculline
    Maximum Cited Publications
    37 Publications Verification

    (+)-Bicuculline

    		 GABA Receptor Neurological Disease
    Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca 2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice [2] .
    Bicuculline
  • HY-17508
    Clarithromycin
    20+ Cited Publications

    		 Bacterial Cytochrome P450 Autophagy Antibiotic Infection Cancer
    Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM [2]. Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
    Clarithromycin
  • HY-15551
    E-4031
    5+ Cited Publications

    		 Potassium Channel Cardiovascular Disease
    E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies .
    E-4031
  • HY-D0143
    Quinine
    5+ Cited Publications

    		 Flavivirus Dengue Virus Parasite Potassium Channel Infection
    Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM [2].
    Quinine
  • HY-B0252
    Hydrochlorothiazide
    5+ Cited Publications

    HCTZ

    		 TGF-beta/Smad Potassium Channel Cardiovascular Disease Metabolic Disease Cancer
    Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect [2] .
    Hydrochlorothiazide
  • HY-Y0537
    Potassium chloride, AR, 99.5%
    2 Publications Verification

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Potassium chloride, AR, 99.5% is extensively used as a potassium supplement. Potassium chloride, AR, 99.5% is a readily available potassium fertilizer. Potassium chloride is promising for research of hyperkalaemia [2].
    Potassium chloride, AR, 99.5%
  • HY-139791
    Azetukalner

    XEN1101

    		 Potassium Channel Neurological Disease
    Azetukalner (XEN1101) is a selective and orally active Kv7.2/Kv7.3 potassium channel opener with an EC50 of 27 nM. Azetukalner is approximately 4-fold more selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50 of 94 nM) and Kv7.4 (EC50 of 113 nM) channels. Azetukalner exhibits a selectivity >100-fold for Kv7 channels over other ion channels and receptors. Azetukalner can be used for the study of focal epilepsy [2].
    Azetukalner
  • HY-Y0537E
    Potassium chloride, for cell culture
    1 Publications Verification

    		 Environmental Pollutants Calcium Channel Potassium Channel Biochemical Assay Reagents Neurological Disease
    Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells [2].
    Potassium chloride, for cell culture
  • HY-12326
    c-di-AMP

    Cyclic diadenylate; Cyclic-di-AMP

    		 STING Bacterial Endogenous Metabolite Inflammation/Immunology
    c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses [2] .
    c-di-AMP
  • HY-109079A
    Abeprazan hydrochloride

    DWP14012 hydrochloride; Fexuprazan hydrochloride

    		 Proton Pump Metabolic Disease
    Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H +, K +- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .
    Abeprazan hydrochloride
  • HY-109079
    Abeprazan

    DWP14012; Fexuprazan

    		 Proton Pump Metabolic Disease
    Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H +, K +- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .
    Abeprazan
  • HY-N7056
    4'-Hydroxychalcone
    3 Publications Verification

    		 Oxidative Phosphorylation Proteasome Inflammation/Immunology Cancer
    4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria [2] .
    4'-Hydroxychalcone
  • HY-Y0319B
    Acetic acid (potassium 99%)
    1 Publications Verification

    potassium acetate

    		 Environmental Pollutants Biochemical Assay Reagents Infection Cancer
    Acetic acid potassium 99% (Potassium acetate) is a potassium salt employed to replenish electrolytes, for restoration of water-electrolyte balance. Acetic acid potassium 99% can employ in DNA and protein purification. Acetic acid potassium 99% has been used to prepare neutralizing solution for alkaline lysis of bacteria and activated carbon [2] .
    Acetic acid (potassium 99%)
  • HY-14290A
    Pinacidil monohydrate
    4 Publications Verification

    P-1134 monohydrate

    		 Potassium Channel Cardiovascular Disease
    Pinacidil (P-1134) monohydrate is a potent activator of ATP-sensitive potassium channel. Pinacidil monohydrate is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K + channels. Pinacidil monohydrate enhances K +-efflux in smooth muscle. Pinacidil monohydrate has vasorelaxant properties. Pinacidil monohydrate is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil monohydrate can be studied in research area such as cardiovascular diseases [2].
    Pinacidil monohydrate
  • HY-17508R
    Clarithromycin (Standard)
    20+ Cited Publications

    		 Reference Standards Bacterial Cytochrome P450 Autophagy Antibiotic Infection Cancer
    Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM [2]. Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
    Clarithromycin (Standard)
  • HY-108595
    VU590
    2 Publications Verification

    		 Potassium Channel Others
    VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney [2].
    VU590
  • HY-157485
    Ebio1

    		Potassium Channel Others
    Ebio1 is a selective voltage-gated potassium channel KCNQ2 activator. Ebio1 activates KCNQ2 by generating an extended channel gate with greater conductance at a saturation voltage (+50 mV) .
    Ebio1
  • HY-159051
    Dragendorff reagent

    		Biochemical Assay Reagents Others
    Dragendorff reagent is used for detecting alkaloids and other nitrogen-containing compounds. Dragendorff reagent is a solution of potassium bismuth iodide composing of Basic bismuth nitrate (Bi(NO3)3), Tartaric acid (HY-N2436), and Potassium iodide (KI). When contact with alkaloids, Dragendorff reagent produces an orange or orange red precipitate .
    Dragendorff reagent
  • HY-12326B
    c-di-AMP diammonium
    15+ Cited Publications

    Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium

    		 STING Bacterial Endogenous Metabolite Inflammation/Immunology
    c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses [2] .
    c-di-AMP diammonium
  • HY-D0143B
    Quinine hemisulfate hydrate
    5+ Cited Publications

    		 Parasite Potassium Channel Infection
    Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV, with an IC50 of 169 μM [2].
    Quinine hemisulfate hydrate
  • HY-175728
    VU6032735

    		Potassium Channel Sodium Channel Calcium Channel Metabolic Disease
    VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception .
    VU6032735
  • HY-108591
    L-364,373

    R-L3

    		 Potassium Channel Cardiovascular Disease
    L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .
    L-364,373
  • HY-158741
    IPG-2 AM

    APG-2 Acetoxymethyl ester

    		 Fluorescent Dye Potassium Channel Others
    IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeant acetoxymethyl ester derivative and selective fluorescent potassium ion indicator. IPG-2 AM exhibits fluorescence increases proportional to extracellular potassium ion concentrations. IPG-2 AM enables real-time monitoring of cytosolic free potassium ion fluxes in human platelets and macrophages. IPG-2 AM can be used for the research of intracellular potassium concentration dynamics [2].
    IPG-2 AM
  • HY-126486
    AVE1231

    A293

    		 Potassium Channel Cardiovascular Disease
    AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation [2].
    AVE1231
  • HY-111996
    Kv3 activator-1

    		Potassium Channel Neurological Disease Inflammation/Immunology
    Kv3 activator-1 is a Kv3 family voltage-gated potassium channel activator. Kv3 activator-1 reverses mechanical hyperalgesia in rat models of neuropathic and inflammatory pain, with rapid onset and long-lasting, dose-related effects. Kv3 activator-1 can be used for the research of pain .
    Kv3 activator-1
  • HY-15208
    Clamikalant sodium

    HMR 1098

    		 Potassium Channel Neurological Disease
    Clamikalant sodium (HMR 1098) is an ATP-sensitive potassium (KATP) channel blocker. Clamikalant sodium can be used for the research of arrhythmia .
    Clamikalant sodium
  • HY-155248
    HL23

    		HDAC Cancer
    HL23 is a histone deacetylase (HDAC) inhibitor with activity against hepatocellular carcinoma (HCC). HL23 enhances acetylation of the TXNIP promoter and upregulates TXNIP expression, thereby mediating potassium channel activity and triggering TXNIP-dependent potassium deprivation. HL23 inhibits HCC progression and metastasis and has a synergistic effect with Sorafenib (HY-10201) and is more potent than Sorafenib+Vorinostat (HY-10221) .
    HL23
  • HY-100783B
    Bicuculline methobromide

    (+)-Bicuculline methobromide

    		 GABA Receptor Neurological Disease
    Bicuculline methobromide is a selective GABAA Receptor antagonist with an IC50 value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca 2+ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders [2].
    Bicuculline methobromide
  • HY-108069
    Iptakalim hydrochloride

    		Potassium Channel nAChR Neurological Disease
    Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist .
    Iptakalim hydrochloride
  • HY-P3055A
    Dendrotoxin-I TFA

    DTX-I TFA

    		 Potassium Channel Cancer
    Dendrotoxin-I (DTX-I) TFA is a potent K + channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research [2] .
    Dendrotoxin-I TFA
  • HY-161092A
    KIO-301 chloride hydrochloride

    		HCN Channel Potassium Channel Neurological Disease
    KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .
    KIO-301 chloride hydrochloride
  • HY-161092
    KIO-301 chloride

    		HCN Channel Potassium Channel Neurological Disease
    KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light .
    KIO-301 chloride
  • HY-W110917
    Dimethylsulfonazo III

    		Biochemical Assay Reagents Others
    Dimethylsulfonazo III is a potent sulfate indicator. Dimethylsulfonazo III can be used as indicator to test those samples contaminated with potassium or phosphate ions [2].
    Dimethylsulfonazo III
  • HY-B1364
    Quinethazone

    		Carbonic Anhydrase Cardiovascular Disease
    Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research [2].
    Quinethazone
  • HY-106895
    L-702958

    		Potassium Channel Cardiovascular Disease
    L-702958 is a potent hERG blocker (IC50 = 14.3 nM). L-702958 can be used for research on arrhythmia .
    L-702958
  • HY-W008585
    Benzo-15-crown-5-ether

    B15C5

    		 Biochemical Assay Reagents Others
    Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .
    Benzo-15-crown-5-ether
  • HY-15551R
    E-4031 (Standard)

    		Potassium Channel Reference Standards Cardiovascular Disease
    E-4031 (Standard) is the analytical standard of E-4031. This product is intended for research and analytical applications. E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies .
    E-4031 (Standard)
  • HY-P5182A
    HsTX1 TFA

    		Potassium Channel Inflammation/Immunology
    HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM and inhibits TEM cell activation and attenuates inflammation in autoimmunity [2] .
    HsTX1 TFA
  • HY-106570
    Tripamide

    		Potassium Channel Metabolic Disease
    Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent .
    Tripamide
  • HY-U00280
    Potassium Channel Activator 1

    		Potassium Channel Neurological Disease
    Potassium Channel Activator 1 ((2,4-Dimethyl-6-morpholin-4-yl-pyridin-3-yl)-carbamic acid benzyl ester) is a potassium channel activator. Potassium Channel Activator 1 can be used for the study diseases or symptoms of dopaminergic system disorders .
    Potassium Channel Activator 1
  • HY-179065
    VU0494372

    		Potassium Channel Cardiovascular Disease
    VU0494372 is an activator of potassium ion channel KCNQ1. VU0494372 can significantly enhance the cell surface expression and transport efficiency of KCNQ1. VU0494372 does not alter KCNQ1 mRNA levels and protein degradation rate, and has no significant cytotoxicity. VU0494372 can be used for research on cardiovascular conditions .
    VU0494372
  • HY-P5925
    Ssm spooky toxin

    SsTx Toxin

    		 Potassium Channel Neurological Disease Inflammation/Immunology
    Ssm Spooky Toxin is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC50s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system [2] .
    Ssm spooky toxin
  • HY-D0143R
    Quinine (Standard)

    		Dengue Virus Flavivirus Reference Standards Parasite Potassium Channel Infection
    Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM [2].
    Quinine (Standard)
  • HY-N0219R
    Bicuculline (Standard)

    (+)-Bicuculline (Standard)

    		 Reference Standards GABA Receptor Neurological Disease
    Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice [2] .
    Bicuculline (Standard)
  • HY-P3055
    Dendrotoxin-I

    DTX-I

    		 Potassium Channel Neurological Disease Cancer
    Dendrotoxin-I (DTX-I) is a potent K + channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research [2] .
    Dendrotoxin-I
  • HY-N13198
    4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside

    		Endogenous Metabolite Metabolic Disease
    4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a pancreatic lipase inhibitor, with an IC50 value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .
    4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside
  • HY-P2785A
    Phrixotoxin-1 TFA

    		Potassium Channel Neurological Disease
    Phrixotoxin-1 (TFA), from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel [2].
    Phrixotoxin-1 TFA
  • HY-P5921
    Tityustoxin-Kα

    TsTx-Kα

    		 Potassium Channel Neurological Disease
    Tityustoxin-Kα (TsTx-Kα) is an inhibitor of potassium voltage-gated channels. Tityustoxin-Kα shows a dose-dependent block of the sustained outward current in cultured hippocampal neurons .
    Tityustoxin-Kα
  • HY-P3111
    Slotoxin

    		Potassium Channel Others
    Slotoxin, a peptide from Centruroides noxius Hoffmann scorpion venom, blocks high conductance calcium-activated potassium channel, with Kd of 1.5 nM[1].
    Slotoxin
  • HY-106895A
    L-702958 hydrochloride

    		Potassium Channel Cardiovascular Disease
    L-702958 hydrochloride is a potent hERG blocker (IC50 = 14.3 nM). L-702958 hydrochloride can be used for research on arrhythmia .
    L-702958 hydrochloride

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