Iptakalim hydrochloride

Name: Iptakalim hydrochloride
Brand: MedChemExpress
SKU: HY-108069
Rating: 4.5 (1 reviews)

Cat. No.: HY-108069 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (K_ATP) opener, as well as an α₄β₂-containing nicotinic acetylcholine receptor (nAChR) antagonist.

For research use only. We do not sell to patients.

Iptakalim hydrochloride Chemical Structure

CAS No. : 642407-63-4

Size	Price	Stock	Quantity
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Iptakalim (Ipt) hydrochloride has been shown to reverse pulmonary resistance vascular remodeling, inhibit proliferation of pulmonary arterial smooth muscle cells (PASMCs) and airway smooth muscle cells (ASMCs), as well as protect PAECs from pathological stimulation^[1].
Iptakalim has an inhibitory effect on [Ca²⁺]cyt increase and the proliferation of pulmonary arterial SMCs induced by endothelin-1 through activation of K_ATP channels. Iptakalim (10 μM, 10 min) pretreatment of pulmonary arterial SMCs significantly prevents ransient ncrease of [Ca²⁺]cyt elicited by endothelin-1^[2].
Iptakalim at he concentrations of 0.1, 1, and 10 AM lowered[3H]thymidine incorporation by 19.75±4.60% (n=10), 41.20±9.49% (n=10), and 54.74±10.11% (n=10), respectively, compared with that of cells treated only with endothelin-1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Iptakalim (10-60 mg/kg) attenuates nicotine-evoked conditioned responding. Iptakalim also attenuates chamber activity in these nicotine test sessions^[3].
. Iptakalim (60 mg/kg) pretreatment significantly reduced activity (LSD comparisons)^[3].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Thirty male Sprague-Dawley rats weighing 275-299 grams^[3].
Dosage:	0, 10, 30, or 60 mg/kg.
Administration:	IP, 10 min before the start of a 4-min test session.
Result:	Decreased chamber activity. Dipper entries following pretreatment with 30 and 60 mg/kg Iptakalim were significantly lower than with 0 (saline) or 10 mg/kg iptakalim pretreatment (Tukey HSD tests).

Molecular Weight

179.73

Formula

C₉H₂₂ClN

CAS No.

642407-63-4

Appearance

Solid

Color

Yellow to orange

SMILES

CC(C)NC(C)(C)C(C)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (139.10 mM; ultrasonic and warming and heat to 70°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5639 mL	27.8195 mL	55.6390 mL
5 mM	1.1128 mL	5.5639 mL	11.1278 mL
10 mM	0.5564 mL	2.7820 mL	5.5639 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (556.39 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (245 KB) HNMR (234 KB)

Handling Instructions (2659 KB)

References

[1]. Mengyu He, et al. Iptakalim ameliorates hypoxia-impaired human endothelial colony-forming cells proliferation, migration, and angiogenesis via Akt/eNOS pathways. Pulm Circ. 2019 Oct 18;9(3):2045894019875417. [Content Brief]

[2]. Weiping Xie, et al. Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells. Eur J Pharmacol. 2005 Mar 28;511(2-3):81-7. [Content Brief]

[3]. S Charntikov, et al. Iptakalim attenuates self-administration and acquired goal-tracking behavior controlled by nicotine. Neuropharmacology. 2013 Dec;75:138-44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.5639 mL	27.8195 mL	55.6390 mL	139.0975 mL
	5 mM	1.1128 mL	5.5639 mL	11.1278 mL	27.8195 mL
	10 mM	0.5564 mL	2.7820 mL	5.5639 mL	13.9098 mL
	15 mM	0.3709 mL	1.8546 mL	3.7093 mL	9.2732 mL
	20 mM	0.2782 mL	1.3910 mL	2.7820 mL	6.9549 mL
	25 mM	0.2226 mL	1.1128 mL	2.2256 mL	5.5639 mL
	30 mM	0.1855 mL	0.9273 mL	1.8546 mL	4.6366 mL
	40 mM	0.1391 mL	0.6955 mL	1.3910 mL	3.4774 mL
	50 mM	0.1113 mL	0.5564 mL	1.1128 mL	2.7820 mL
	60 mM	0.0927 mL	0.4637 mL	0.9273 mL	2.3183 mL
	80 mM	0.0695 mL	0.3477 mL	0.6955 mL	1.7387 mL
	100 mM	0.0556 mL	0.2782 mL	0.5564 mL	1.3910 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.