2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. HsTX1 TFA

HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM and inhibits TEM cell activation and attenuates inflammation in autoimmunity.

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HsTX1 TFA Chemical Structure

HsTX1 TFA Chemical Structure

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5 mg USD 815 In-stock
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Other Forms of HsTX1 TFA:

HsTX1 TFA Related Antibodies

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Description

HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM and inhibits TEM cell activation and attenuates inflammation in autoimmunity[1][2][3].

Molecular Weight

3818.47 (free base)

Formula

C149H246N54O46S9.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Ala-Ser-Cys-Arg-Thr-Pro-Lys-Asp-Cys-Ala-Asp-Pro-Cys-Arg-Lys-Glu-Thr-Gly-Cys-Pro-Tyr-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Asn-Arg-Cys-NH2 (Disulfide Bridge: Cys3-Cys24; Cys9-Cys29; Cys13-Cys31; Cys19-Cys34)
Sequence Shortening

ASCRTPKDCADPCRKETGCPYGKCMNRKCKCNRC-NH2 (Disulfide Bridge: Cys3-Cys24; Cys9-Cys29; Cys13-Cys31; Cys19-Cys34)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
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HsTX1 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HsTX1HsTX 1HsTX-1Potassium ChannelKcsAPotassium Channel InhibitorAutoimmune DisorderInhibitorinhibitorinhibit

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