GSK-588045
GSK-588045 is a potent 5-HT(1A/B/D) receptor antagonist. GSK-588045 shows high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channels. GSK-588045 can be used for the research of neurological disease, such as depression and anxiety.
For research use only. We do not sell to patients.
- CAS No.: 876922-98-4
- Formula: C27H28N6O2
- Molecular Weight:468.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT1A Receptor |
5-HT1B/D Receptor |
Chemical Information
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CAS No. 876922-98-4
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Molecular Weight 468.55
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Formula C27H28N6O2
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SMILES
CC1=CC=C2C(C=CC=C2N3CCN(CCC4=C(OCC5=C(C(N)=O)N=CN56)C6=CC=C4)CC3)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Bromidge SM, et al. Design and synthesis of novel tricyclic benzoxazines as potent 5-HT(1A/B/D) receptor antagonists leading to the discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045). J Med Chem. 2010 Aug 12;53(15):5827-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-588045 Related Classifications
HY-10800 Related Classifications
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