876922-98-4
Chemical Structure
GSK-588045
- CAS No.: 876922-98-4
- Formula:C27H28N6O2
- Molecular Weight:468.55
IUPAC Name: 6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethyl)-4H-benzo[b]imidazo[1,5-d][1,4]oxazine-3-carboxamide
InChIKey: HLQJZFFWUXHYMB-UHFFFAOYSA-N
SMILES: CC1=CC=C2C(C=CC=C2N3CCN(CCC4=C(OCC5=C(C(N)=O)N=CN56)C6=CC=C4)CC3)=N1
Biological Activity: GSK-588045 is a potent 5-HT(1A/B/D) receptor antagonist. GSK-588045 shows high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channels. GSK-588045 can be used for the research of neurological disease, such as depression and anxiety[1].
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GSK-588045 | GSK-588045 is a potent 5-HT(1A/B/D) receptor antagonist. GSK-588045 shows high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channels. GSK-588045 can be used for the research of neurological disease, such as depression and anxiety. | |||||||||||||||||||||
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- [1]. Bromidge SM, et al. Design and synthesis of novel tricyclic benzoxazines as potent 5-HT(1A/B/D) receptor antagonists leading to the discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045). J Med Chem. 2010 Aug 12;53(15):5827-43. [Content Brief]
Keywords
