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Cat. No.: HY-19244

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JTV-506

JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine (HY-B1204)-induced contraction of tracheal smooth muscle by activation of K_ATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research.

For research use only. We do not sell to patients.

CAS No.: 170148-29-5
Formula: C₁₉H₂₂N₄O₅
Molecular Weight:386.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

JTV-506 Chemical Structure

CAS No.: 170148-29-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

JTV-506 (1 nM-100 μM, 15 min) causes a concentration-dependent inhibition of Histamine-induced contraction in guinea-pig isolated tracheal smooth muscle, and is antagonized by Glibenclamide (HY-15206)^[1].
JTV-506 (1 nM-100 μM) relaxes norepinephrine-preconstricted, endothelium-intact arteries from Monocrotaline (MCT) (HY-N0750)-treated and control rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 170148-29-5
Molecular Weight 386.40
Formula C₁₉H₂₂N₄O₅
SMILES

N#CC1=CC=C2C([C@@H](NC(C=C3)=NN(C)C3=O)[C@H](O)C(COC)(COC)O2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ando T, et al. Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure. Clin Exp Allergy. 1997 Jun;27(6):705-13. [Content Brief]

[2]. Tsutsumi Y, et al. JTV-506, a new K(ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth. 2004;18(3):210-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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