2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel Sodium Channel Calcium Channel
  4. VU6032735

VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception.

For research use only. We do not sell to patients.

VU6032735

VU6032735 Chemical Structure

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VU6032735 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception[1].

IC50 & Target[1]

hSLO3

165 nM (IC50)

mSLO3

730 nM (IC50)

L-type calcium channel

 

In Vitro

VU6032735 (10 μM, 1-2 h) significantly inhibits human sperm hyperactivated motility[1].
VU6032735 (0.01-1 μM) inhibits mouse SLO3-γ2 channels in HEK293 cells[1].
VU6032735 (10 μM) inhibits sodium channel and L-type calcium channel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU6032735 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 MRT CL Vss AUC
Mice[1] 5 mg/kg i.v. 33.7 h 45.9 h 8.6 mL/min/kg 23.6 L/kg 9835 ng·h/mL
Rat[1] 0.2 mg/kg i.v. 2.19 h 2.66 h 29.3 mL/min/kg 4.69 L/kg 114 ng·h/mL
In Vivo

VU6032735 (10 mg/kg, i.p.) sustain high tissue exposure in ovaries, oviducts, and uterus over 24 h in female mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

525.44

Formula

C25H21F6N3O3
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(OCC2=CC=C(OC(F)(F)F)C=C2)C=C1)N3CCN(C4=NC=C(C(F)(F)F)C=C4)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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VU6032735 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU6032735VU 6032735VU-6032735Potassium ChannelSodium ChannelCalcium ChannelKcsANa channelsNa+ channelsCa2+ channelsCa channelsPotassium channelSodium channelL-type calcium channelContraceptionInhibitorinhibitorinhibit

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