VU6032735
Based on 1 Customer Validation
VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception.
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- Purity: 99.26%
- 화학식: C25H21F6N3O3
- 분자량:525.44
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
All Calcium Channel Isoforms
More
Biological Activity
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hSLO3 165 nM (IC50) |
mSLO3 730 nM (IC50) |
L-type calcium channel |
VU6032735 (10 μM, 1-2 h) significantly inhibits human sperm hyperactivated motility[1].
VU6032735 (0.01-1 μM) inhibits mouse SLO3-γ2 channels in HEK293 cells[1].
VU6032735 (10 μM) inhibits sodium channel and L-type calcium channel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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분자량 525.44
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화학식 C25H21F6N3O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(OCC2=CC=C(OC(F)(F)F)C=C2)C=C1)N3CCN(C4=NC=C(C(F)(F)F)C=C4)CC3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
순도&문서
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)