NE-10133
NE-10133 is a ISK and IKS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias.
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- CAS No.: 149889-02-1
- Formule: C23H30Cl3N5O4
- Masse moléculaire:546.87
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
NE-10133 potently inhibits rat ISK channels expressed in Xenopus oocytes, with an EC50 of 12 μM; at concentrations up to 20 μM, it exerts no effect on RBK1, RBK2 or RGK5 potassium channels[2].
NE-10133 potently inhibits the IKs potassium current in guinea pig ventricular myocytes with an EC50 of 11 μM, and its efficacy is comparable to its inhibitory effect on rat ISK channels in Xenopus oocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 149889-02-1
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Masse moléculaire 546.87
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Formule C23H30Cl3N5O4
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SMILES
O=C1N(CC(N1CCCN2CCN(CC2)CCO)=O)/N=C/C3=CC=C(C4=CC=C(Cl)C=C4)O3.Cl.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Bao JJ, et al. Separation and quantitation of azimilide and its putative metabolites by capillary electrophoresis. J Chromatogr B Biomed Sci Appl. 1998;720(1-2):129-140. [Content Brief]
[2]. Busch AE, et al. The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochem Biophys Res Commun. 1994;202(1):265-270. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NE-10133 Related Classifications
HY-182646 Related Classifications
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