149889-02-1
149889-02-1
Chemical Structure
NE-10133
- CAS No.: 149889-02-1
- Formula:C23H30Cl3N5O4
- Molecular Weight:546.87
InChIKey: PHFFZLIQGNLRRH-BYEGLACWSA-N
SMILES: O=C1N(CC(N1CCCN2CCN(CC2)CCO)=O)/N=C/C3=CC=C(C4=CC=C(Cl)C=C4)O3.Cl.Cl
Biological Activity: NE-10133 is a ISK and IKS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias[1][2].
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NE-10133 | NE-10133 is a ISK and IKS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias. | |||||||||||||||||||||
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References
- [1]. Bao JJ, et al. Separation and quantitation of azimilide and its putative metabolites by capillary electrophoresis. J Chromatogr B Biomed Sci Appl. 1998;720(1-2):129-140. [Content Brief]
- [2]. Busch AE, et al. The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochem Biophys Res Commun. 1994;202(1):265-270. [Content Brief]
