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Results for "

Aminopeptidases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (3) Aminopeptidase (88) Amyloid-β (1) Androgen Receptor (2) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (14) Apoptosis (6) Bacterial (28) Biochemical Assay Reagents (12) Bradykinin Receptor (1) Carboxypeptidase (2) Caspase (1) COX (1) Dipeptidyl Peptidase (10) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Intermediate (3) Endogenous Metabolite (4) Endothelin Receptor (1) Enteropeptidase (2) Ephrin Receptor (1) Epoxide Hydrolase (1) ERK (2) Farnesyl Transferase (1) Fluorescent Dye (7) Fungal (1) GCGR (1) GnRH Receptor (1) HDAC (1) IAP (1) IKK (1) Insulin Receptor (1) Isotope-Labeled Compounds (3) Leukotriene Receptor (4) Ligands for Target Protein for PROTAC (1) Lipase (1) Melanocortin Receptor (1) MetAP (15) MMP (4) Monoamine Oxidase (1) mTOR (2) MyD88 (1) Neprilysin (3) Neurotensin Receptor (1) NF-κB (3) NO Synthase (1) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (4) p38 MAPK (1) Parasite (7) Phosphatase (3) Phosphorylase (1) Potassium Channel (2) PPAR (1) Prolyl Endopeptidase (PREP) (1) Proteasome (1) PSMA (2) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (4) Reference Standards (8) Renin (1) Ser/Thr Protease (2) Somatostatin Receptor (5) Toll-like Receptor (TLR) (1) Tyrosine Hydroxylase (1) VEGFR (1)
By Research Areas:	Cancer (51) Cardiovascular Disease (14) Endocrinology (4) Infection (36) Inflammation/Immunology (23) Metabolic Disease (28) Neurological Disease (24)

By Targets:

Amino Acid Derivatives (3)

Aminopeptidase (88)

Amyloid-β (1)

Androgen Receptor (2)

Angiotensin Receptor (1)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (14)

Apoptosis (6)

Bacterial (28)

Biochemical Assay Reagents (12)

Bradykinin Receptor (1)

Carboxypeptidase (2)

Caspase (1)

COX (1)

Dipeptidyl Peptidase (10)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Drug Derivative (1)

Drug Intermediate (3)

Endogenous Metabolite (4)

Endothelin Receptor (1)

Enteropeptidase (2)

Ephrin Receptor (1)

Epoxide Hydrolase (1)

ERK (2)

Farnesyl Transferase (1)

Fluorescent Dye (7)

Fungal (1)

GCGR (1)

GnRH Receptor (1)

HDAC (1)

IAP (1)

IKK (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (4)

Ligands for Target Protein for PROTAC (1)

Lipase (1)

Melanocortin Receptor (1)

MetAP (15)

MMP (4)

Monoamine Oxidase (1)

mTOR (2)

MyD88 (1)

Neprilysin (3)

Neurotensin Receptor (1)

NF-κB (3)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (4)

p38 MAPK (1)

Parasite (7)

Phosphatase (3)

Phosphorylase (1)

Potassium Channel (2)

PPAR (1)

Prolyl Endopeptidase (PREP) (1)

Proteasome (1)

PSMA (2)

Pyroptosis (1)

Radionuclide-Drug Conjugates (RDCs) (4)

Reference Standards (8)

Renin (1)

Ser/Thr Protease (2)

Somatostatin Receptor (5)

Toll-like Receptor (TLR) (1)

Tyrosine Hydroxylase (1)

VEGFR (1)

By Research Areas:

Cancer (51)

Cardiovascular Disease (14)

Endocrinology (4)

Infection (36)

Inflammation/Immunology (23)

Metabolic Disease (28)

Neurological Disease (24)

180

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0134

Bestatin Maximum Cited Publications 11 Publications Verification Ubenimex	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-B0134A

Bestatin hydrochloride Maximum Cited Publications 11 Publications Verification Ubenimex hydrochloride	Antibiotic Bacterial Aminopeptidase	Infection Cancer
Bestatin hydrochloride is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-14807

Tosedostat 5+ Cited Publications CHR-2797	Aminopeptidase	Cancer
Tosedostat (CHR-2797) is an orally active *aminopeptidase* inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines .

HY-113952

Actinonin 5+ Cited Publications (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-133125

ERAP1-IN-1 5 Publications Verification	Aminopeptidase	Inflammation/Immunology
ERAP1-IN-1 is an *endoplasmic reticulum aminopeptidase* 1 (ERAP1)** inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .

HY-115194

Amastatin hydrochloride 1 Publications Verification	Aminopeptidase Bacterial	Infection
Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K_i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase .

HY-114336

Enocyanin 3 Publications Verification	Phosphatase	Inflammation/Immunology
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dye	Others
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-W009004

Trilysine Lys-Lys-Lys; H-Lys-Lys-Lys-OH	Biochemical Assay Reagents	Others
Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

HY-101932

TNP-470 2 Publications Verification AGM-1470	Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

HY-151518

Aminopeptidase-IN-1	Aminopeptidase	Neurological Disease
Aminopeptidase-IN-1 is an insulin-regulated aminopeptidase (IRAP) inhibitor with an K_i value of 7.7 μM. Aminopeptidase-IN-1 can be used for the research of memory impairments .

HY-16710

GPDA 1 Publications Verification GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dye	Others
GPDA (GPN; Glycylproline p-nitroanilide tosylate) is a chromogenic substrate of prolyl dipeptidyl aminopeptidase. GPDA is used to detect the activity of prolyl dipeptidyl aminopeptidase in human serum .

HY-W015876

L-Leucinol (+)-Leucinol	Aminopeptidase	Others
L-Leucinol ((+)-Leucinol) is a competitive *aminopeptidase* inhibitor with a K_i value of 17 μM. As a dietary intake inhibitor, L-Leucinol reduces the basal dietary leucine intake in rats via microinjection into the rat anterior piriform cortex .

HY-E70199

Aminopeptidase N (rat) APN/CD13	Aminopeptidase	Cardiovascular Disease
Aminopeptidase N (rat) (APN/CD13) is a Zn ²⁺-dependent membrane-bound exopeptidase that preferentially degrades proteins and peptides with N-terminal neutral amino acids. Aminopeptidase N (rat) is inhibited by angiotensin IV and participates in the regulation of angiotensin IV half-life in the rat striatum .

HY-P2779

*Microsomal aminopeptidase, Microorganism*	Endogenous Metabolite	Metabolic Disease
Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .

HY-W011911

L-Leucyl-4-nitroanilide	Biochemical Assay Reagents	Others
L-Leucyl-4-nitroanilide is a colorimetric substrate for leucine aminopeptidase assays.

HY-W016477

Phenazine	Bacterial	Infection
Phenazine is an electron shuttles, which modulates the redox state of cells and the downstream gene expression related to biofilm formation and bacterial survival. Phenazines is a biocontrol agents, which affects the growth of plants and induces the systemic resistance in plants. Phenazine maintains NAD+/NADH balance .

HY-133016

M8891	MetAP	Cardiovascular Disease Cancer
M8891 is an orally active, reversible and brain penetrant *Methionine Aminopeptidase-2 (MetAP-2)* inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .

HY-148442

ecMetAP-IN-1	MetAP Bacterial	Infection
ecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC₅₀ of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli .

HY-177590

14-3-3-IN-2	MMP	Others
14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC₅₀ of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels .

HY-13731

PPI-2458	MetAP	Inflammation/Immunology Cancer
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .

HY-W027340

ARM1 1 Publications Verification 4BSA	Aminopeptidase Epoxide Hydrolase	Cancer
ARM1 (4BSA) is a potent *aminopeptidase* and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM .

HY-118953

LAF389	MetAP	Cancer
LAF389, a benaamide B analogue, is a methionine aminopeptidases (MetAps) inhibitor with an IC₅₀ of 800 nM for MetAp2. LAF389 has both antiproliferative and antiangiogenetic properties and can inhibit tumor cells growth. LAF389 can be used for the research of cancer .

HY-147401

Sitagliptin fenilalanil 1 Publications Verification	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

HY-110259

HFI-142 1 Publications Verification	Aminopeptidase	Neurological Disease
HFI-142 is an *insulin-regulated aminopeptidase* (IRAP) inhibitor with a K_i** of 2.01 μM .

HY-W011539

EcMetAP1-IN-1	Bacterial	Infection
EcMetAP1-IN-1 (compound 4) is an inhibitor of Escherichia coli methionine aminopeptidase MetAP1 .

HY-B0134AS

Bestatin-d7 hydrochloride Ubenimex-d7 hydrochloride	Isotope-Labeled Compounds Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-122369

Histargin	Carboxypeptidase	Metabolic Disease
Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B .

HY-117702

RB 101	Prolyl Endopeptidase (PREP) Aminopeptidase	Metabolic Disease
RB 101 is an active mixed inhibitor against two enzymes which metabolize the enkephalins neutral endopeptidase and aminopeptidase N. RB 101 has rather long-lasting antinociceptive effects. RB 101 inhibits the in vivo [ ³H]DPN binding both under basal conditions and after swim stress in mice. RB 101 can be used to determine the precise in vivo localization of enkephalinergic pathways recruited by various stimuli .

HY-P1044

Spinorphin LVV-hemorphin-4	Carboxypeptidase	Neurological Disease
Spinorphin is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-P1044A

Spinorphin TFA LVV-hemorphin-4 TFA	Angiotensin Receptor	Neurological Disease
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-133016A

(R)-M8891	MetAP	Others
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .

HY-160239

HFI-437	Aminopeptidase	Neurological Disease
HFI-437 is a potent non-peptidic *insulin-regulated aminopeptidase* (IRAP) inhibitor with a K_i** of 20 nM. HFI-437 is a cognitive enhancer .

HY-109188

Relzomostat	MetAP	Metabolic Disease
Relzomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor.Relzomostat may be useful for the research of obesity, type 2 diabetes, and other obesity-associated conditions .

HY-137528

H-Glu(4MβNA)-OH H-Glu(4MbetaNA)-OH; L-Glutamic acid γ-(4-methoxy-β-naphthylamide)	Aminopeptidase	Others
H-Glu(4MβNA)-OH is a substrate of aminopeptidases (APs) .

HY-W250725

H-GLU-AMC-OH	Fluorescent Dye	Neurological Disease
H-GLU-AMC-OH is an amino acid derivative that can be used as A fluorescent peptide substrate for the determination of aminopeptidase A enzyme activity .

HY-P2928

Aeromonas proteolytica aminopeptidase	Biochemical Assay Reagents Aminopeptidase	Others
Aeromonas proteolytica aminopeptidase is an aminopeptidase from Aeromonas proteolytica. Aeromonas proteolytica aminopeptidase can function as an esterase. Aeromonas proteolytica aminopeptidase can catalyze the hydrolysis of L-leucine ethyl ester (L-Leu-OEt) with a K_m of 700 µM .

HY-147401A

Sitagliptin fenilalanil hydrochloride 1 Publications Verification	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil hydrochloride is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

HY-P4549

H-D-Ala-D-Ala-D-Ala-D-Ala-OH	Aminopeptidase	Others
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase .

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-E70571

Glycylproline dipeptidyl aminopeptidase	Aminopeptidase	Metabolic Disease
Glycylproline dipeptidyl aminopeptidase is an enzyme that catalyzes the hydrolysis of N-terminal glycylproline from glycylprolyl-β-naphthylamide and glycylproline-β-nitroanilide .

HY-137159

Bestatin methyl ester	Aminopeptidase Ligands for Target Protein for PROTAC IAP	Cancer
Bestatin methyl ester is a cell permeable Zn2+-binding aminopeptidases inhibitor. Bestatin methyl ester inhibits spore cell differentiation .

HY-P4584

TRH-βNA	Biochemical Assay Reagents	Others
TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .

HY-P4658

H-Val-Ala-pNA	Dipeptidyl Peptidase	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

HY-129298

Amastatin	Aminopeptidase	Others
Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC₅₀ of 0.54 μg/mL for AP-A .

HY-W794670

H-Ala-Pro-Ala-OH	Aminopeptidase	Others
H-Ala-Pro-Ala-OH, tripeptide, is a substrate for Escherichia coli PepP (Xaa-Pro aminopeptidase). H-Ala-Pro-Ala-OH acts as a nitrogen source for wild-type Escherichia coli .

HY-163727

MMV1557817	Parasite	Infection
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites .

HY-W009906

2-(2′-Pyridyl)benzimidazole	Aminopeptidase	Inflammation/Immunology
2-(2’-Pyridyl)benzimidazole is a potentially tridentate ligand that can form stable complexes with various transition metal ions. 2-(2’-Pyridyl)benzimidazole can be used as an anti-inflammatory agent and an inhibitor of Escherichia coli methionine *aminopeptidase* .

HY-P4205

Aminopeptidase N Ligand (CD13) NGR peptide	Aminopeptidase	Cancer
Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research .

HY-P2842

*Aminopeptidase*	Biochemical Assay Reagents	Others Cancer
Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .

Cat. No.	Product Name	Type

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dyes
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-16710

GPDA 1 Publications Verification GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dyes
GPDA (GPN; Glycylproline p-nitroanilide tosylate) is a chromogenic substrate of prolyl dipeptidyl aminopeptidase. GPDA is used to detect the activity of prolyl dipeptidyl aminopeptidase in human serum .

HY-137928

H-Ala-4MβNA hydrochloride	Fluorescent Dyes
H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .

HY-D3191

L&M-D-MR

Fluorescent Dyes

L&M-D-MR is a highly specific fluorescent "AND" logic probe with response moieties for leucine aminopeptidase (LAP) and monoamine oxidase (MAO). The coexistence of both LAP and MAO is required for L&M-D-MR to trigger intramolecular cyclization, release fluorophores and activate fluorescence. In the presence of only a single enzyme, L&M-D-MR generates only an extremely weak signal. L&M-D-MR enables bioimaging in living cells and mouse models, and can effectively distinguish different subtypes of liver diseases via blood samples or test strips. L&M-D-MR is widely used in studies related to liver cirrhosis, hepatitis B and drug-induced liver injury .

Cat. No.	Product Name	Type

HY-W016477

Phenazine	Biochemical Assay Reagents
Phenazine is an electron shuttles, which modulates the redox state of cells and the downstream gene expression related to biofilm formation and bacterial survival. Phenazines is a biocontrol agents, which affects the growth of plants and induces the systemic resistance in plants. Phenazine maintains NAD+/NADH balance .

HY-137895

L-Arginine p-nitroanilide dihydrochloride, 98% H-Arg-pNA 2HCl, 98%	Biochemical Assay Reagents
L-Arginine p-nitroanilide dihydrochloride, 98% (H-Arg-pNA 2HCl, 98%) is a chromogenic substrate for cathepsin H and aminopeptidases.

HY-137901

L-Alanine 4-nitroanilide hydrochloride, 99% Ala-4-nitroanilide, 99%; H-Ala-pNA, 99%	Biochemical Assay Reagents
L-Alanine 4-nitroanilide hydrochloride, 99% is a detection substrate for L-alanine aminopeptidase.

HY-W016477R

Phenazine (Standard)	Biochemical Assay Reagents
Phenazine is an electron shuttles, which modulates the redox state of cells and the downstream gene expression related to biofilm formation and bacterial survival. Phenazines is a biocontrol agents, which affects the growth of plants and induces the systemic resistance in plants. Phenazine maintains NAD+/NADH balance .

HY-W286423

L-Pyroglutamic acid 7-amido-4-methylcoumarin	Biochemical Assay Reagents
L-Pyroglutamic acid 7-amido-4-methylcoumarin is a fluorogenic substrate for *pyroglutamate aminopeptidase* 1 (PGP-1)** .

Cat. No.	Product Name	Target	Research Area

HY-P4070

Insulin icodec	Insulin Receptor	Metabolic Disease
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA_1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .

HY-W009004

Trilysine Lys-Lys-Lys; H-Lys-Lys-Lys-OH	Biochemical Assay Reagents	Others
Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

HY-105055

Didemnin B	Peptides	Cancer
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P5362

NODAGA-LM3	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Neurological Disease Cancer
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-P2336A

CCZ01048 TFA 3 Publications Verification	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .

HY-111173

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

HY-P10341

ZP3022	GCGR	Metabolic Disease
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .

HY-P1044A

Spinorphin TFA LVV-hemorphin-4 TFA	Angiotensin Receptor	Neurological Disease
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-P2648

Suc-Ala-Ala-Pro-Leu-pNA N-Succinyl-AAPL-p-nitroanilide	Aminopeptidase	Endocrinology
Suc-Ala-Ala-Pro-Leu-pNA (N-Succinyl-AAPL-p-nitroanilide) is a tripeptidyl p-nitroanilide substrate that can be catalytically hydrolyzed by acyl amidase-like leucine aminopeptidase in seminal plasma. Amastatin (HY-129298) and Actinonin (HY-113952) exert potent inhibitory effects on this hydrolytic activity. Suc-Ala-Ala-Pro-Leu-pNA can be used for the research of diseases such as azoospermia .

HY-P4549

H-D-Ala-D-Ala-D-Ala-D-Ala-OH	Aminopeptidase	Others
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase .

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-P4584

TRH-βNA	Biochemical Assay Reagents	Others
TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .

HY-P4658

H-Val-Ala-pNA	Dipeptidyl Peptidase	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

HY-P11334

Cyanostatin B	Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis	Cancer
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability. .

HY-W794670

H-Ala-Pro-Ala-OH	Aminopeptidase	Others
H-Ala-Pro-Ala-OH, tripeptide, is a substrate for Escherichia coli PepP (Xaa-Pro aminopeptidase). H-Ala-Pro-Ala-OH acts as a nitrogen source for wild-type Escherichia coli .

HY-P4205

Aminopeptidase N Ligand (CD13) NGR peptide	Aminopeptidase	Cancer
Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research .

HY-P4553

H-Met-Pro-OH	Amino Acid Derivatives	Others
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .

HY-P4553A

H-Met-Pro-OH acetate	Amino Acid Derivatives	Others
H-Met-Pro-OH acetate is a dipeptide containing methionine and proline. H-Met-Pro-OH acetate serves as a substrate for aminopeptidase P (APP) and skin fibroblast prolinase .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-P11004

A3-APO	Bacterial Antibiotic	Infection
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .

HY-P10472

Azaline B	GnRH Receptor	Endocrinology
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC₅₀ of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .

HY-P4757

N1-Glutathionyl-spermidine disulfide	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-P11243

EphA4 agonist compound 23	Ephrin Receptor	Neurological Disease
EphA4 agonist compound 23 is a novel EphA4 agonist peptide mimic. EphA4 agonist compound 23 exhibits high affinity, high selectivity, and significant receptor activation ability. EphA4 agonist compound 23 is commonly used in the study of neurodegenerative diseases .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

HY-P5362A

NODAGA-LM3 TFA	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-115431

Antho-rwamide I	Aminopeptidase	Neurological Disease
Antho-rwamide I is a neuropeptide that can be isolated from the sea anemone Anthopleura elegantissima. Antho-rwamide I is resistant to nonspecific aminopeptidases, which increases the stability of the peptide after neuronal release .

HY-137946

L-Leucine 4-methoxy-β-naphthylamide hydrochloride	Aminopeptidase	Others
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate .

HY-P5607

Bombinin	Bacterial Antibiotic Aminopeptidase	Infection
Bombinin is an antimicrobial peptide derived from frog Bombina variegata. Bombinin has a protective effect on aminopeptidase .

HY-W009004B

Trilysine TFA Lys-Lys-Lys TFA; H-Lys-Lys-Lys-OH TFA	Aminopeptidase	Others
Trilysine TFA is a tripeptide and also a substrate for specific peptidases. Trilysine TFA serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

HY-P4461

Ala-Ala-Pro-pNA	Peptides	Others
Ala-Ala-Pro-pNA is a tripeptide, including chromophoric amino acids Pro-pNA. Ala-Ala-Pro-pNA is targeted by tripeptidyl aminopeptidase (SM-TAP) .

HY-P4393

H-Leu-Trp-Met-Arg-OH	Aminopeptidase	Others
H-Leu-Trp-Met-Arg-OH is a tetrapeptide. H-Leu-Trp-Met-Arg-OH can be used as a substrate for *aminopeptidase*-mediated hydrolysis studies .

HY-P4227A

WRVYEKC(dnp)ALK tetraTFA	Peptides	Metabolic Disease
WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate .

HY-P4528

Ala-Phe-Pro-βNA	Ser/Thr Protease	Others
Ala-Phe-Pro-βNA is the subsrate of prolyl tripeptidyl aminopeptidase, which is from Porphyromonas gingivalis. Ala-Phe-Pro-βNA binds to H-Ala-Ile-pyrrolidin-2-yl boronic acid for PTP39 and the E636A mutant with K_i values of 88.1 nM and 48.8 nM, respectivley .

HY-P2075

EMD 55068	Renin	Endocrinology
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .

HY-P10876

mcK6A1	Amyloid-β	Neurological Disease
mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .

HY-P11642

Sialorphin	ERK Androgen Receptor Opioid Receptor Enteropeptidase mTOR Aminopeptidase	Neurological Disease Inflammation/Immunology Cancer
Sialorphin is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin is also a copper (II) ion-binding ligand. Sialorphin has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-103294

R892	Endogenous Metabolite	Others
R892 is a selective and efficient bradyK_inin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability .

HY-P11488

JR11-PEG3-DOTA-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-DOTA-PSMA-03 (Compound 2) is an RDC-related compound containing the chelating agent DOTA (HY-W053583), the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-DOTA-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 94.0 nM, 81.8 nM, respectively. JR11-PEG3-DOTA-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-DOTA-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

HY-P11485

JR11-PEG3-HBED-CC-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0134

Bestatin Maximum Cited Publications 11 Publications Verification Ubenimex	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-B0134A

Bestatin hydrochloride Maximum Cited Publications 11 Publications Verification Ubenimex hydrochloride	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Antibiotic Bacterial Aminopeptidase
Bestatin hydrochloride is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-113952

Actinonin 5+ Cited Publications (-)-Actinonin	Infection Natural Products Microorganisms Classification of Application Fields Marine natural products Disease Research Fields Source Classification	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-114336

Enocyanin 3 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields Inflammation/Immunology Source Classification	Phosphatase
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-105055

Didemnin B	Natural Products Animals Classification of Application Fields Marine natural products Other marine organisms Disease Research Fields Source Classification Cancer	Others
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-122369

Histargin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Carboxypeptidase
Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B .

HY-126564

Ebelactone A	Natural Products Microorganisms Source Classification	Lipase MetAP
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis .

HY-N2150

Psammaplin A	Structural Classification Classification of Application Fields Marine natural products Antibacterial Disease Research Other Antibiotics Infection Microorganisms Animals Antibiotics Phenols Polyphenols Sponge Anticancer Disease Research Fields Source Classification	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Aminopeptidase Farnesyl Transferase PPAR Apoptosis
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC₅₀: 45 nM), DNA methyltransferases (IC₅₀: 18.6 nM) and aminopeptidase N (APN) (IC₅₀: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .

HY-121071

Ascamycin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Nucleoside Antimetabolite/Analog Antibiotic
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against *Xanthomonas* species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for *Xanthomonas citri, Xanthomonas oryzae* and *Mycobacterium phlei*, respectively .

HY-116126

Leuhistin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Aminopeptidase
Leuhistin is an AP-M (aminopeptidase-M) inhibitor. AP-M is an inactivating enzyme of bioactive peptides in cerebral membranes. Leuhistin can be produced by Bacillus laterosporus BMI156-14F1 .

HY-B0134R

Bestatin (Standard) Ubenimex (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aminopeptidase Bacterial Antibiotic
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-N9898

Sinocrassoside C1	Structural Classification Flavonols Sinocrassula indica (Decne.) Berger Flavonoids Crassulaceae Plants Source Classification	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-125422

Matlystatin A	Natural Products Microorganisms Source Classification	Aminopeptidase
Matlystatin A is a potent *aminopeptidase* inhibitor, with IC₅₀ values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. Matlystatin A can be utilized in cancer research .

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Aminopeptidase Bacterial Antibiotic
Bestatin trifluoroacetate is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-113952R

Actinonin (Standard) (-)-Actinonin (Standard)	Natural Products Microorganisms Source Classification	Reference Standards Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin (Standard) is the analytical standard of Actinonin. This product is intended for research and analytical applications. Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

HY-116306

Probestin	Natural Products Microorganisms Source Classification	Aminopeptidase
Probestin is a potent aminopeptidase N (APN) inhibitor produced by Streptomyces cyanogens MH663-2F6 .

HY-B0134AR

Bestatin hydrochloride (Standard) Ubenimex hydrochloride (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aminopeptidase Bacterial Antibiotic
Bestatin (hydrochloride) (Standard) is the analytical standard of Bestatin (hydrochloride). This product is intended for research and analytical applications. Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-125564

Acetyltrialanine	Natural Products Microorganisms Source Classification	Aminopeptidase
Acetyltrialanine is a peptide containing three amino acid residues in which the N-terminal amino acid is acetylated and used as a substrate for Nα-acetyl alanine aminopeptidase in order to study the activity and properties of the enzyme. Acetyltrialanine can be used in the study of protein degradation and N-terminal regulation .

HY-N15079

Arphamenine B	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Arphamenine B is a Zn ²⁺-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases .

HY-N19847

LYRM03	Structural Classification Microorganisms Peptides Source Classification	Drug Derivative Aminopeptidase Endogenous Metabolite Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) NF-κB p38 MAPK IKK NO Synthase COX
LYRM03 is a derivative of Ubenimex (HY-B0134) and a Aminopeptidase N inhibitor. LYRM03 is isolated from Streptomyces HCCB10043. LYRM03 inhibits TLR4, MyD88, NLRP3, ASC, NF-κB and p38 MAPK, stabilizes IκB, and suppresses LPS-induced expression of iNOS and COX-2. LYRM03 reduces the levels of inflammatory cytokines and oxidative stress markers, and alleviates pulmonary edema. LYRM03 exhibits anticancer activity against breast cancer. LYRM03 has anti-inflammatory activity. LYRM03 can be used in the research of acute lung injury and breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-B0134AS

Bestatin-d7 hydrochloride
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-123193S

Avizafone-d5 dihydrobromide

Avizafone-d₅ dihydrobromide is the deuterium labeled Avizafone dihydrobromide . Avizafone (Pro-diazepam) dihydrobromide, a pro-drug of Diazepam, is an anticonvulsant agent. Avizafone dihydrobromide can be used as an antidote of nerve agent poisoning. In vivo, Avizafone is rapidly hydrolyzed by aminopeptidase to produce lysine and diazepam. Avizafone dihydrobromide has research areas including neurological disease, such as epilepsy.

HY-B0134S1

Bestatin-d10
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

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