2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Insulin icodec

Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Insulin icodec

Insulin icodec Chemical Structure

CAS No. : 1188379-43-2

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Based on 1 publication(s) in Google Scholar

Insulin icodec Related Antibodies

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Description

Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus[1][2].

In Vitro

Insulin icodec (48 h at 37°C) is stable in rat, monkey, and human plasma (retaining ≥89.76% after 48 h at 37°C) but showed reduced stability in mouse plasma (82.89% retention after 48 h at 37°C)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Insulin icodec Related Antibodies
Parmacokinetics
Species Dose Route Tmax Cmax AUC0-t T1/2
Rat[1] 2 nmol/Kg s.c. 6.5 h 69.9 ng/mL 2029 ng·h/mL 18.9 h
Dog[1] 2 nmol/Kg s.c. 6-24 h 79.1 ng/mL 6872 ng·h/mL 61.9 h
In Vivo

Insulin icodec (3-6 mg/kg; s.c.; once every 2 days; for 52 consecutive days) exerts a hypoglycemic effect, and reduces HbA1c levels by -7.96% (3 mg/kg) and -11.49% (6 mg/kg) relative to baseline in BKS-db/db mice with type 2 diabetes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BKS-db/db mice (male, 5-6 weeks old, 30-40 g, T2DM db/db model)[1]
Dosage: 3 mg/kg; 6 mg/kg
Administration: s.c.; every two days; 52 days
Result: Showed similar blood glucose trend to TBE001-A-S033; reduced HbA1c levels by -7.96% (3 mg/kg) and -11.49% (6 mg/kg) relative to baseline.
Molecular Weight

6380.26

Formula

C280H435N71O87S6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

Sequence

Chain1:Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-His-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-His-Tyr-Thr-Pro-{Lys(2OEG-γGlu-C20 diacid)} Chain2:Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-His-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-His-Tyr-Thr-Pro-Lys Chain3:{Ggu}-{Oaa}-{Oaa}(Disulfide:Chain1 Cys7-Chain2 Cys7, Disulfide:Chain1 Cys19-Chain2 Cys20, Disulfide:Chain 2 Cys6-Cys11, Amide bridge:Chain1 Lys29 to Chain3 ω-amino acid3)
Sequence Shortening

Chain1:FVNQHLCGSHLVEALHLVCGERGFHYTP-{Lys(2OEG-γGlu-C20 diacid)}; Chain2:GIVEQCCTSICSLEQLENYCN; Chain3:{Ggu}-{Oaa}-{Oaa} (Disulfide:Chain1 Cys7-Chain2 Cys7, Disulfide:Chain1 Cys19-Chain2 Cys20, Disulfide:Chain2 Cys6-Cys11, Amide bridge:Chain1 Lys29 to Chain3 ω-amino acid3)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at 4°C, do not freeze
Purity & Documentation

Purity: 95%

SDS (251 KB)

COA (232 KB)

Handling Instructions (2659 KB)
References
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Insulin icodec Related Classifications

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Insulin icodec1188379-43-2Insulin Receptorhuman serum albuminSD ratsinsulin receptorHbA1cICR miceBKS-db/db micefasting plasma glucosebeagle dogsCHO-hIR cellstype 2 diabetes mellitusInhibitorinhibitorinhibit

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