Spinorphin
Spinorphin is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect.
For research use only. We do not sell to patients.
- CAS No.: 137201-62-8
- Formula: C45H64N8O10
- Molecular Weight:877.04
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | IC50 |
48.1 pM
Compound: 5, spinorphin
|
Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current in presence of 20 nM LVVYPWA peptide by two electrode voltage clamping technique
Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current in presence of 20 nM LVVYPWA peptide by two electrode voltage clamping technique
|
[PMID: 17676725] |
| Oocyte | IC50 |
8.3 pM
Compound: 5, spinorphin
|
Antagonist activity at human P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current by two electrode voltage clamping technique
Antagonist activity at human P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current by two electrode voltage clamping technique
|
[PMID: 17676725] |
Chemical Information
-
CAS No. 137201-62-8
-
Molecular Weight 877.04
-
Formula C45H64N8O10
-
SMILES
C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H]3N(C([C@H](CC4=CC=C(C=C4)O)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@H](CC(C)C)N)=O)=O)=O)=O)CCC3)=O)=O
-
Synonyms
LVV-hemorphin-4
-
Sequence
Leu-Val-Val-Tyr-Pro-Trp-Thr
-
Sequence Shortening
LVVYPWT
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz