1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    Nucleoside Antimetabolite/Analog
  3. Ascamycin

Ascamycin 

Cat. No.: HY-121071
Handling Instructions

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.

For research use only. We do not sell to patients.

Ascamycin Chemical Structure

Ascamycin Chemical Structure

CAS No. : 91432-48-3

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Description

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively[1][2][3].

IC50 & Target

MIC: 0.4 μg/mL (Xanthomonas citri), 12.5 μg/mL (Xanthomonas oryzae) and 12.5 μg/mL (Mycobacterium phlei)[1]

In Vitro

The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine[1]. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface[2].

Molecular Weight

451.84

Formula

C₁₃H₁₈ClN₇O₇S

CAS No.

91432-48-3

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C(N=C(Cl)N=C21)N)O3)O)[[email protected]]3COS(=O)(NC([[email protected]@H](N)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AscamycinBacterialNucleoside Antimetabolite/AnalogAdenosineantibiotic5'-O-sulfonamideribonucleosideaminopeptidaseantimicrobialXanthomonasInhibitorinhibitorinhibit

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Ascamycin
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