Ascamycin
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.
For research use only. We do not sell to patients.
- CAS No.: 91432-48-3
- Formula: C13H18ClN7O7S
- Molecular Weight:451.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MIC: 0.4 μg/mL (Xanthomonas citri), 12.5 μg/mL (Xanthomonas oryzae) and 12.5 μg/mL (Mycobacterium phlei)[1]
The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine[1]. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 91432-48-3
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Molecular Weight 451.84
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Formula C13H18ClN7O7S
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SMILES
O[C@@H]([C@H]([C@H](N1C=NC2=C(N=C(Cl)N=C21)N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)C)=O)=O
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Structure Classification
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Initial Source
Streptomyces sp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo). 1984 Jun;37(6):670-2. [Content Brief]
[2]. Osada H, rt al. Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri. Biochem J. 1986 Jan 15;233(2):459-63. [Content Brief]
[3]. Zhao C, et al. Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5'-O-sulfonamide moiety in Streptomyces sp. JCM9888. PLoS One. 2014 Dec 5;9(12):e114722. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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