2-(2′-Pyridyl)benzimidazole

Cat. No.: HY-W009906 Pureza: 99.88%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

2-(2’-Pyridyl)benzimidazole is a potentially tridentate ligand that can form stable complexes with various transition metal ions. 2-(2’-Pyridyl)benzimidazole can be used as an anti-inflammatory agent and an inhibitor of Escherichia coli methionine aminopeptidase.

Para uso exclusivo en investigación. No vendemos a pacientes.

2-(2′-Pyridyl)benzimidazole Estructura química

No. CAS : 1137-68-4

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
25 g	En stock	Estimated Time of Arrival: December 31
50 g	En stock	Estimated Time of Arrival: December 31
100 g	En stock	Estimated Time of Arrival: December 31
> 100 g	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Aminopeptidase:

Ver todas las isoformas

CD13 LTA4H

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	13.3 μM Compound: 25	Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells	[PMID: 20621724]

Peso molecular

195.22

Fòrmula

C₁₂H₉N₃

No. CAS

1137-68-4

Appearance

Solid

Color

Pale purple to purple

SMILES

C12=CC=CC=C1NC(C3=CC=CC=N3)=N2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 50 mg/mL (256.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1224 mL	25.6121 mL	51.2243 mL
5 mM	1.0245 mL	5.1224 mL	10.2449 mL
10 mM	0.5122 mL	2.5612 mL	5.1224 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (12.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 99.88%

Select Batch:

Ficha de datos (273 KB) SDS (393 KB)

COA (249 KB) HNMR (132 KB) RP-HPLC (216 KB) LCMS (96 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Serratrice M, et al. Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2'-pyridyl)benzimidazole as ligand: comparisons of gold(III) versus gold(I) and mononuclear versus binuclear derivatives. Inorg Chem. 2012 Mar 5;51(5):3161-71. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.1224 mL	25.6121 mL	51.2243 mL	128.0606 mL
	5 mM	1.0245 mL	5.1224 mL	10.2449 mL	25.6121 mL
	10 mM	0.5122 mL	2.5612 mL	5.1224 mL	12.8061 mL
	15 mM	0.3415 mL	1.7075 mL	3.4150 mL	8.5374 mL
	20 mM	0.2561 mL	1.2806 mL	2.5612 mL	6.4030 mL
	25 mM	0.2049 mL	1.0245 mL	2.0490 mL	5.1224 mL
	30 mM	0.1707 mL	0.8537 mL	1.7075 mL	4.2687 mL
	40 mM	0.1281 mL	0.6403 mL	1.2806 mL	3.2015 mL
	50 mM	0.1024 mL	0.5122 mL	1.0245 mL	2.5612 mL
	60 mM	0.0854 mL	0.4269 mL	0.8537 mL	2.1343 mL
	80 mM	0.0640 mL	0.3202 mL	0.6403 mL	1.6008 mL
	100 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.2806 mL