DDD00057570

Cat. No.: HY-158690 Purity: 99.69%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DDD00057570 is a selective M17 leucyl-aminopeptidase (LAP) inhibitor. DDD00057570 inhibits L. major and L. donovani intracellular amastigotes in vitro growth.

For research use only. We do not sell to patients.

DDD00057570 Chemical Structure

CAS No. : 338965-07-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

DDD00057570 is a selective M17 leucyl-aminopeptidase (LAP) inhibitor. DDD00057570 inhibits L. major and L. donovani intracellular amastigotes in vitro growth^[1].

Molecular Weight

307.35

Formula

C₁₇H₁₇N₅O

CAS No.

338965-07-4

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C=C1)CC2=C(N=C(N=C2N)C3=CC=CC=N3)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (325.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2536 mL	16.2681 mL	32.5362 mL
5 mM	0.6507 mL	3.2536 mL	6.5072 mL
10 mM	0.3254 mL	1.6268 mL	3.2536 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (247 KB) HNMR (256 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Aguado ME, et al. Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17. ACS Infect Dis. 2024 May 16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2536 mL	16.2681 mL	32.5362 mL	81.3405 mL
	5 mM	0.6507 mL	3.2536 mL	6.5072 mL	16.2681 mL
	10 mM	0.3254 mL	1.6268 mL	3.2536 mL	8.1340 mL
	15 mM	0.2169 mL	1.0845 mL	2.1691 mL	5.4227 mL
	20 mM	0.1627 mL	0.8134 mL	1.6268 mL	4.0670 mL
	25 mM	0.1301 mL	0.6507 mL	1.3014 mL	3.2536 mL
	30 mM	0.1085 mL	0.5423 mL	1.0845 mL	2.7113 mL
	40 mM	0.0813 mL	0.4067 mL	0.8134 mL	2.0335 mL
	50 mM	0.0651 mL	0.3254 mL	0.6507 mL	1.6268 mL
	60 mM	0.0542 mL	0.2711 mL	0.5423 mL	1.3557 mL
	80 mM	0.0407 mL	0.2034 mL	0.4067 mL	1.0168 mL
	100 mM	0.0325 mL	0.1627 mL	0.3254 mL	0.8134 mL

DDD00057570 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDD00057570338965-07-4DDD 00057570DDD-00057570ParasiteAminopeptidaseLeishmaniaLAPM17 leucyl-aminopeptidaseInhibitorinhibitorinhibit

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