2. Metabolic Enzyme/Protease
  3. Aminopeptidase
  4. Aminopeptidase N (rat)

Aminopeptidase N (rat) (APN/CD13) is a Zn2+-dependent membrane-bound exopeptidase that preferentially degrades proteins and peptides with N-terminal neutral amino acids. Aminopeptidase N (rat) is inhibited by angiotensin IV and participates in the regulation of angiotensin IV half-life in the rat striatum.

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Aminopeptidase N (rat)

Aminopeptidase N (rat) Chemical Structure

CAS No. : 9054-63-1

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Aminopeptidase N (rat) Related Antibodies

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Description

Aminopeptidase N (rat) (APN/CD13) is a Zn2+-dependent membrane-bound exopeptidase that preferentially degrades proteins and peptides with N-terminal neutral amino acids. Aminopeptidase N (rat) is inhibited by angiotensin IV and participates in the regulation of angiotensin IV half-life in the rat striatum[1][2][3][4].

In Vitro

Aminopeptidase N (rat) accounted for 60 % of the total aminopeptidase activity in rat striatal cell membranes[1].
Aminopeptidase N (rat)'s over-expression reduces basolateral Na+/K+ ATPase activity and abundance in LLCPK-1 proximal tubule cells, with this effect dependent on signaling via the AT4 receptor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aminopeptidase N (rat) Related Antibodies
In Vivo

Aminopeptidase N (rat)‘s (10-500 nM; local perfusion via microdialysis probe; 60 min) inhibition alone does not alter striatal dopamine release in rats[1].
Aminopeptidase N (rat) (intracerebroventricular infusion; microinfusion into paraventricular nucleus of the hypothalamus) reduces arterial blood pressure in both spontaneously hypertensive and normotensive rats, with a more pronounced effect in spontaneously hypertensive rats, via an angiotensin type 1 receptor-dependent mechanism[2].
Aminopeptidase N (rat) has increased renal abundance and activity in salt-resistant rat strains fed a high-salt diet, supporting a role in renal salt adaptation and blood pressure regulation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, 250-300 g)[1]
Dosage: 10 nM, 100 nM, 500 nM
Administration: local perfusion via microdialysis probe; 60 min
Result: Caused no significant change in extracellular dopamine concentrations in the rat striatum, with levels remaining near baseline (100%) throughout and after perfusion (10 nM, 100 nM, 500 nM inhibitor 7B alone).
Potentiated the angiotensin IV-induced increase in striatal dopamine levels, resulting in a maximal increase of approximately 350% of baseline at 60 min of co-perfusion.
Completely abolished the angiotensin IV-induced dopamine increase, with dopamine levels remaining at baseline (500 nM inhibitor 7B + 10 µM angiotensin IV, combined APN and IRAP inhibition).
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[Aminopeptidase N (rat)]
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References
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Aminopeptidase N (rat) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminopeptidase N (rat)9054-63-1APN/CD13AminopeptidaseIRAPspontaneously hypertensive ratsdopaminesolid tumorsangiotensin IIILLCPK-1 proximal tubule cellsangiotensin IVAT4 receptorrat striatumInhibitorinhibitorinhibit

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