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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
128 Results for "
granule
" in MedChemExpress (MCE) Product Catalog:
Products (128)
128 Results for "granule" in MCE Product Catalog:
9
9 Publications Verification
Cat. No.: HY-162288
CAS No.: 3036029-72-5
Target:
Research Areas:
FAZ-3532 is a G3BP inhibitor (Kd = 0.54 μM) which binds to the NTF2L nsP3 binding pocket in G3BP1. FAZ-3532 disrupts the co-condensation of RNA, G3BP1, and caprin 1. FAZ-3532 inhibits G3BP-driven stress granule formation. FAZ-3532 can be studied as a powerful tool to probe the biology of stress granules and a promising interventions designed to modulate stress granule formation .
6
6 Cited Publications
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Research Areas:
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation .
6
6 Cited Publications
Cat. No.: HY-112680
CAS No.: 1417638-60-8
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Research Areas:
Carboxypyridostatin is a G-quadruplex ligand. Carboxypyridostatin has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxypyridostatin reduces cell proliferation and hinders stress granule (SG) formation .
3
3 Cited Publications
Cat. No.: HY-162289
CAS No.: 3036029-78-1
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FAZ-3780 is an inhibitor that binds to the NTF2L domain of G3BP1/2. FAZ-3780 binds to the NTF2L nsP3 of G3BP1 with high affinity, with a Kd of 0.15 μM and a Pep-FRET IC50 of 0.7 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2, and specifically inhibits the co-condensation of G3BP1, caprin 1 and RNA in vitro. FAZ-3780 inhibits stress granule formation and disassembles pre-formed stress granules. FAZ-3780 can be used in studies related to cancer and neurodegenerative diseases .
2
2 Cited Publications
Cat. No.: HY-W040045
CAS No.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride
1
1
1 Cited Publications
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Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis .
1
1 Cited Publications
Synonyms: β-NAAG; β-N-Acetylaspartylglutamic acid
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β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies .
1
1 Cited Publications
Cat. No.: HY-P76059
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SRGN; Proteoglycan 1, Secretory granule; Prev. PRG1; P.PG; Prev. PRG; Proteoglycan Protein Core For Mast Cell Secretory granule; PPG; Secretory granule Proteoglycan Core Peptide; Secretory granule Proteoglycan Core Protein; Hematopoetic Proteoglycan Core
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P76058
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SRGN; Proteoglycan 1, Secretory granule; Prev. PRG1; P.PG; Prev. PRG; Proteoglycan Protein Core For Mast Cell Secretory granule; PPG; Secretory granule Proteoglycan Core Peptide; Secretory granule Proteoglycan Core Protein; Hematopoetic Proteoglycan Core
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P70803
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELP; Selectin P (granule Membrane Protein 140kDa, Antigen CD62); Prev. GRMP; LECAM3; P-Selectin; Selectin P (granule Membrane Protein 140kD, Antigen CD62); PADGEM; Leukocyte-Endothelial Cell Adhesion Molecule 2; Platelet Activation Dependent granule-Exte
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P70509
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRTN3; Neutrophil Proteinase 4; Proteinase 3; Leukocyte Proteinase 3; AGP7; Wegener Autoantigen; PR-3; C-ANCA Antigen; P29; NP-4; Myeloblastin; MBN; C-ANCA; PR3; ACPA; Azurophil granule Protein 7; MBT; CANCA; Wegener Granulomatosis Autoantigen; NP4; Serin
Species:
Human
Source:
HEK293
1
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke .
1
1 Cited Publications
Cat. No.: HY-P1080
CAS No.: 145017-83-0
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Cat. No.: HY-P991028
CAS No.: 2892667-02-4
Synonyms: AZD0486; TNB-486
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Research Areas:
Target:
Synonyms: FD&C RED NO. 40; CI 16035
Cat. No.: HY-D2348A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
