2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Endogenous Metabolite
  4. Androst-16-en-3-ol

Androst-16-en-3-ol is a pheromone derived from boars that triggers mating responses in estrous sows. It also exists in human urine, plasma, saliva and sweat. As an endogenous neurosteroid, Androst-16-en-3-ol acts as a positive allosteric modulator of GABAA receptors (GABAA receptor) and exerts anxiolytic, antidepressant and anticonvulsant activities in mice.

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Androst-16-en-3-ol

Androst-16-en-3-ol Estructura química

No. CAS : 7148-51-8

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Androst-16-en-3-ol Related Antibodies

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Descripciòn

Androst-16-en-3-ol is a pheromone derived from boars that triggers mating responses in estrous sows. It also exists in human urine, plasma, saliva and sweat. As an endogenous neurosteroid, Androst-16-en-3-ol acts as a positive allosteric modulator of GABAA receptors (GABAA receptor) and exerts anxiolytic, antidepressant and anticonvulsant activities in mice.
In Vitro

Androstenol (15-20 s preapplication and coapplication with GABA) positively modulates GABAA receptors in mouse cerebellar slices with an EC50 of 1.4 μM, enhancing GABA-activated currents in a concentration-dependent manner[1].
Androstenol (0.1-300 μM) potentiates GABAA receptors in HEK 293 cells transfected with α1β2γ2 or α2β2γ2 subunits at 0.1-1 μM and directly activates these receptors at 10-300 μM[1].
Androstenol prolongs the duration of spontaneous inhibitory postsynaptic currents in mouse cultured cerebellar granule cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Androst-16-en-3-ol Related Antibodies
In Vivo

Androst-16-en-3-ol (10-100 mg/kg; i.p.; single dose) displays anxiolytic-like effects in mice[1].
Androst-16-en-3-ol (5-10 mg/kg; i.p.; single dose) exhibits antidepressant-like effects in mice in the forced swim test[1].
Androst-16-en-3-ol (10-100 mg/kg; i.p.; single dose 15 minutes before seizure induction) has anticonvulsant activity in mice[1].
Androst-16-en-3-ol (100-300 mg/kg; i.p.; single dose) causes motor impairment in mice at high doses with a TD50 of 181 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 10, 30, 50, 100 mg/kg
Administration: i.p.; single dose immediately before testing
Result: Significantly increased the area-under-the-curve for percent time spent in the center of the arena at 30 and 50 mg/kg.
Reduced horizontal activity at 100 mg/kg, making center time values unmeaningful.
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 10, 30, 50 mg/kg
Administration: i.p.; single dose 15 minutes before testing
Result: Caused a dose-dependent reduction in latency to first open arm entry, increase in number of open arm entries, and increase in percent time spent in open arms; observed significant effects at doses of 10-50 mg/kg depending on the measure.
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 5, 10, 30 mg/kg
Administration: i.p.; single dose 15 minutes before testing
Result: Reduced immobility times compared with vehicle at 5 and 10 mg/kg; showed no activity at 30 mg/kg.
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 10, 30, 100 mg/kg
Administration: i.p.; single dose 15 minutes before seizure induction
Result: Conferred dose-dependent protection against seizures in both pentylenetetrazol and 6 Hz electroshock models; reached ED50 values of 21.9 mg/kg (6 Hz model) and 48.9 mg/kg (pentylenetetrazol model).
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 100, 200, 300 mg/kg
Administration: i.p.; single dose 15 minutes before testing
Result: Caused no impairment at 100 mg/kg; impaired 4/6 mice at 200 mg/kg and 5/6 at 300 mg/kg; reached a TD50 value of 181 mg/kg.
Peso molecular

274.44

Fòrmula

C19H30O
No. CAS
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C=CC4)C
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Room temperature in continental US; may vary elsewhere.
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Androst-16-en-3-ol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Androst-16-en-3-ol7148-51-83β-AndrostenolGABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptormouseHEK 293 cellscerebellar granule cell GABAA receptorsα1β2γ2 subtypeseizure disordersanxietydepression-like behaviorGABAA receptorα2β2γ2 subtypeblood-brain barrierInhibitorinhibitorinhibit

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