SB2960
SB2960 is a receptor for activated protein C kinase 1 (RACK1) binder with a human KD of 5.65 μM. SB2960 can promote stress granule (SG) formation and exhibit potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. SB2960 increases the thermal stability of RACK1 and reduces SARS-CoV-2 N protein levels. SB2960 enhances type I interferon (IFN-β) expression and inhibits RIG-I, ISG56, and RANTES expression. SB2960 can be used for the research of virus infection.
For research use only. We do not sell to patients.
- CAS No.: 3111225-79-4
- Formula: C34H31F3N8O3
- Molecular Weight:656.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RACK1 |
SARS-CoV-2 |
SB2960 (1.2-100 μM) induces stress granule formation in Vero cells with an EC50 of 12.31 μM and reduces SARS-CoV-2 N protein levels in a dose-dependent manner[1].
SB2960 (0.2-100 μM) demonstrates broad-spectrum antiviral activity against multiple RNA viruses in Vero, Calu-3, and Huh7 cells with IC50 values between 3.01 and 5.45 μM[1].
SB2960 (20 μM; 24 h) modulates antiviral gene expression in G3BP1-GFP U-2 OS cells treated with poly(I:C)[1].
SB2960 (0-30 μM) synergizes with Remdesivir (HY-104077) and Nirmatrelvir (HY-138687) against SARS-CoV-2 in Vero cells with high ZIP synergy scores[1].
SB2960 (0.39-700 μM; 24 h) exhibits low cytotoxicity in Vero and G3BP1-GFP U-2 OS cells with a CC50 > 100 μM[1].
SB2960 (20 μM; 24 h) increases the thermal stability of RACK1 in Vero and G3BP1-GFP U-2 OS cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero and G3BP1-GFP U-2 OS cells
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Concentration:40 μM (CETSA)
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Incubation Time:2 h (CETSA)
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Result:Increased the thermal stability of RACK1, with a higher melting temperature (Tm) compared to DMSO-treated cells.
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Cell Line:G3BP1-GFP U-2 OS cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Enhanced IFN-β expression in poly(I:C)-stimulated cells while attenuating RIG-I, ISG56, and RANTES expression.
Chemical Information
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CAS No. 3111225-79-4
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Molecular Weight 656.66
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Formula C34H31F3N8O3
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SMILES
CC1(C)OC2=CC(N3CCN(C(C4=NC=CN4C)=O)CC3)=C(NC(C5=NC=CC=C5)=O)C=C2C6=C1C=NN6C7=CC=C(C(F)(F)F)C=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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