2. Epigenetics TGF-beta/Smad Anti-infection Immunology/Inflammation
  3. PKC SARS-CoV IFNAR
  4. SB2960

SB2960 is a receptor for activated protein C kinase 1 (RACK1) binder with a human KD of 5.65 μM. SB2960 can promote stress granule (SG) formation and exhibit potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. SB2960 increases the thermal stability of RACK1 and reduces SARS-CoV-2 N protein levels. SB2960 enhances type I interferon (IFN-β) expression and inhibits RIG-I, ISG56, and RANTES expression. SB2960 can be used for the research of virus infection.

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SB2960

SB2960 Chemical Structure

CAS No. : 3111225-79-4

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SB2960 Related Antibodies

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Description

SB2960 is a receptor for activated protein C kinase 1 (RACK1) binder with a human KD of 5.65 μM. SB2960 can promote stress granule (SG) formation and exhibit potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. SB2960 increases the thermal stability of RACK1 and reduces SARS-CoV-2 N protein levels. SB2960 enhances type I interferon (IFN-β) expression and inhibits RIG-I, ISG56, and RANTES expression. SB2960 can be used for the research of virus infection[1].

IC50 & Target[1]

RACK1

 

SARS-CoV-2

 

In Vitro

SB2960 (1.2-100 μM) induces stress granule formation in Vero cells with an EC50 of 12.31 μM and reduces SARS-CoV-2 N protein levels in a dose-dependent manner[1].
SB2960 (0.2-100 μM) demonstrates broad-spectrum antiviral activity against multiple RNA viruses in Vero, Calu-3, and Huh7 cells with IC50 values between 3.01 and 5.45 μM[1].
SB2960 (20 μM; 24 h) modulates antiviral gene expression in G3BP1-GFP U-2 OS cells treated with poly(I:C)[1].
SB2960 (0-30 μM) synergizes with Remdesivir (HY-104077) and Nirmatrelvir (HY-138687) against SARS-CoV-2 in Vero cells with high ZIP synergy scores[1].
SB2960 (0.39-700 μM; 24 h) exhibits low cytotoxicity in Vero and G3BP1-GFP U-2 OS cells with a CC50 > 100 μM[1].
SB2960 (20 μM; 24 h) increases the thermal stability of RACK1 in Vero and G3BP1-GFP U-2 OS cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB2960 Related Antibodies

Western Blot Analysis[1]

Cell Line: Vero and G3BP1-GFP U-2 OS cells
Concentration: 40 μM (CETSA)
Incubation Time: 2 h (CETSA)
Result: Increased the thermal stability of RACK1, with a higher melting temperature (Tm) compared to DMSO-treated cells.

Real Time qPCR[1]

Cell Line: G3BP1-GFP U-2 OS cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Enhanced IFN-β expression in poly(I:C)-stimulated cells while attenuating RIG-I, ISG56, and RANTES expression.
Molecular Weight

656.66

Formula

C34H31F3N8O3
CAS No.
SMILES

CC1(C)OC2=CC(N3CCN(C(C4=NC=CN4C)=O)CC3)=C(NC(C5=NC=CC=C5)=O)C=C2C6=C1C=NN6C7=CC=C(C(F)(F)F)C=C7
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB2960 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB29603111225-79-4SB 2960SB-2960PKCSARS-CoVIFNARProtein kinase CSARS coronavirusInterferon-α/β receptorInterferon-alpha/beta receptortype I interferon (IFN-β)Vero cellsRNA virusesSARS-CoV-2Calu-3dengue virusInhibitorinhibitorinhibit

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