MN-05 

MN-05 is a dual neuroprotective and vasodilatory NMDA receptor inhibitor.MN-05 blocks calcium influx, reduces free radical production, and maintains mitochondrial membrane potential in cortical neurons exposed to glutamate.MN-05 dilates aortic rings against phenylephrine-induced contraction.MN-05 protects neurons against glutamate-induced injury in vitro.MN-05 can be used for the research of neurodegenerative diseases^[1].

MN-05 (0.1-100 μM; 24 h) potently protects primary cerebellar granule neurons against glutamate-induced injury, with an EC₅₀ of 10.68 μM^[1].
MN-05 (5-45 μM; 24 h) protects primary rat cortical neurons against glutamate-induced injury in vitro in a concentration-dependent manner^[1].
MN-05 (5-15 μM; 5 min) inhibits glutamate-induced intracellular calcium influx in primary cortical neurons^[1].
MN-05 (5-45 μM; 12 h) concentration-dependently inhibits the production of reactive oxygen/nitrogen species in primary cortical neurons induced by glutamate^[1].
MN-05 (5-45 μM; 12 h) maintains mitochondrial membrane potential in a concentration-dependent manner and inhibits glutamate-induced mitochondrial dysfunction in primary cortical neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

254.33

C₁₃H₂₂N₂O₃

1835197-63-1

NC(C1)(CC(C2)(C3)CC)CC2CC13CO[N+]([O-])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu Z, et al. Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases. Medchemcomm. 2016;8(1):135-147. Published 2016 Oct 20.  [Content Brief]