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Cat. No.: HY-P10996

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Corticostatin, human TFA

(Synonyms: Human Neutrophil Peptide-4 TFA)

Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candida albicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients.

For research use only. We do not sell to patients.

Formula: C₁₅₉H₂₅₆F₃N₄₉O₄₅S₆.xC₂HF₃O₂
Molecular Weight:3709.43 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Corticostatin, human TFA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 3709.43 (free base)
Formula C₁₅₉H₂₅₆F₃N₄₉O₄₅S₆.xC₂HF₃O₂
Synonyms

Human Neutrophil Peptide-4 TFA
Sequence

Val-Cys-Ser-Cys-Arg-Leu-Val-Phe-Cys-Arg-Arg-Thr-Glu-Leu-Arg-Val-Gly-Asn-Cys-Leu-Ile-Gly-Gly-Val-Ser-Phe-Thr-Tyr-Cys-Cys-Thr-Arg-Val (Disulfide bridge:Cys2-Cys30,Cys4-Cys19,Cys9-Cys29)
Sequence Shortening

VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV (Disulfide bridge:Cys2-Cys30,Cys4-Cys19,Cys9-Cys29)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ehmann D, et al. Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria. Front Microbiol. 2020 Jun 3;11:1147. [Content Brief]

[2]. Wilde CG, et al. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem. 1989 Jul 5;264(19):11200-3. [Content Brief]

[3]. Loffredo MR, et al. Antimicrobial peptides for novel antiviral strategies in the current post-COVID-19 pandemic. J Pept Sci. 2024 Jan;30(1):e3534. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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