Z19024498
Z19024498 is a heat sensitizer. Z19024498 inhibits SAFB granule formation under heat stress conditions. Z19024498 enhances heat stress-induced Apoptosis. Z19024498 exerts anticancer activity against cervical cancer in synergy with heat stress.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1005147-23-8
- 分子式: C14H19Cl2N3O2
- 分子量:332.23
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Z19024498 (5 μM; 1 h pre-incubation at 37°C, 1 h co-incubation with 43°C heat stress, followed by 24 h recovery at 37°C without compound) significantly enhances heat stress-induced cell growth inhibition in HeLa cells[1].
Z19024498 (0-20 μM; 1 h pre-incubation at 37°C, 1 h co-incubation with 43°C heat stress) inhibits standalone SAFB granule formation (IC50 = 10.7 μM) and SAFB granule colocalization with HSF1 granules (IC50 = 2.7 μM) in heat-stressed HeLa cells, without altering HSF1 granule formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, H1299, AsPC1, HepG2, HEK293T
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Concentration:0-25 μM (GI50 determination); 5 μM (post-heat stress incubation)
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Incubation Time:37 °C for 1 h, followed by incubation at 43 °C for 1 h, followed by 24 h incubation at 37°C with 5 μM compound
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Result:Achieved a GI50 of 5.3 μM (37°C) and 3.1 μM (43°C), with a TER of 1.7 in HeLa cells.
Achieved a GI50 of 4.1 μM (37°C) and 1.6 μM (43°C), with a TER of 2.6 in H1299 cells.
Achieved a GI50 of 18.7 μM (37°C) and 15.6 μM (43°C), with a TER of 1.2 in AsPC1 cells.
Achieved a GI50 of 40.8 μM (37°C) and 3.4 μM (43°C), with a TER of 12 in HepG2 cells.
Achieved a GI50 of 10.5 μM (37°C) and 6.0 μM (43°C), with a TER of 1.8 in HEK293T cells.
Produced all TER values >1.0, indicating synergistic enhancement of hyperthermic effects.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c-nu/nu nude mice (6-week-old female; HeLa cell xenograft)[1]
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Dosage:3 mg/kg
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Administration:i.p.; twice (days 0 and 8, 1 hour before hyperthermia)
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Result:Reduced tumor volume compared with DMSO-treated mice.
Extended lifespan slightly compared with DMSO-treated controls.
Combined with hyperthermia, significantly suppressed tumor growth compared with DMSO, Z19024498 alone, or hyperthermia alone, with significantly reduced tumor volumes on day 14 and significantly lower tumor weight on day 28 compared with hyperthermia alone.
Extended lifespan slightly compared with hyperthermia alone when combined with hyperthermia.
Caused no changes in body weight, indicating minimal to no physiological toxicity.
化学情報
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CAS 番号 1005147-23-8
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分子量 332.23
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分子式 C14H19Cl2N3O2
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SMILES
O=C(NC1C(C)C(C)CCC1)CN2C(C(Cl)=C(Cl)C=N2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Z19024498 関連分類
HY-181794 関連分類
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