Z19024498
Z19024498 is a heat sensitizer. Z19024498 inhibits SAFB granule formation under heat stress conditions. Z19024498 enhances heat stress-induced Apoptosis. Z19024498 exerts anticancer activity against cervical cancer in synergy with heat stress.
For research use only. We do not sell to patients.
- CAS No.: 1005147-23-8
- Formula: C14H19Cl2N3O2
- Molecular Weight:332.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Z19024498 (5 μM; 1 h pre-incubation at 37°C, 1 h co-incubation with 43°C heat stress, followed by 24 h recovery at 37°C without compound) significantly enhances heat stress-induced cell growth inhibition in HeLa cells[1].
Z19024498 (0-20 μM; 1 h pre-incubation at 37°C, 1 h co-incubation with 43°C heat stress) inhibits standalone SAFB granule formation (IC50 = 10.7 μM) and SAFB granule colocalization with HSF1 granules (IC50 = 2.7 μM) in heat-stressed HeLa cells, without altering HSF1 granule formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, H1299, AsPC1, HepG2, HEK293T
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Concentration:0-25 μM (GI50 determination); 5 μM (post-heat stress incubation)
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Incubation Time:37 °C for 1 h, followed by incubation at 43 °C for 1 h, followed by 24 h incubation at 37°C with 5 μM compound
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Result:Achieved a GI50 of 5.3 μM (37°C) and 3.1 μM (43°C), with a TER of 1.7 in HeLa cells.
Achieved a GI50 of 4.1 μM (37°C) and 1.6 μM (43°C), with a TER of 2.6 in H1299 cells.
Achieved a GI50 of 18.7 μM (37°C) and 15.6 μM (43°C), with a TER of 1.2 in AsPC1 cells.
Achieved a GI50 of 40.8 μM (37°C) and 3.4 μM (43°C), with a TER of 12 in HepG2 cells.
Achieved a GI50 of 10.5 μM (37°C) and 6.0 μM (43°C), with a TER of 1.8 in HEK293T cells.
Produced all TER values >1.0, indicating synergistic enhancement of hyperthermic effects.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c-nu/nu nude mice (6-week-old female; HeLa cell xenograft)[1]
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Dosage:3 mg/kg
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Administration:i.p.; twice (days 0 and 8, 1 hour before hyperthermia)
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Result:Reduced tumor volume compared with DMSO-treated mice.
Extended lifespan slightly compared with DMSO-treated controls.
Combined with hyperthermia, significantly suppressed tumor growth compared with DMSO, Z19024498 alone, or hyperthermia alone, with significantly reduced tumor volumes on day 14 and significantly lower tumor weight on day 28 compared with hyperthermia alone.
Extended lifespan slightly compared with hyperthermia alone when combined with hyperthermia.
Caused no changes in body weight, indicating minimal to no physiological toxicity.
Chemical Information
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CAS No. 1005147-23-8
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Molecular Weight 332.23
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Formula C14H19Cl2N3O2
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SMILES
O=C(NC1C(C)C(C)CCC1)CN2C(C(Cl)=C(Cl)C=N2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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