2. Apoptosis
  3. Apoptosis
  4. Z19024498

Z19024498 is a heat sensitizer. Z19024498 inhibits SAFB granule formation under heat stress conditions. Z19024498 enhances heat stress-induced Apoptosis. Z19024498 exerts anticancer activity against cervical cancer in synergy with heat stress.

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Z19024498

Z19024498 Chemical Structure

CAS No. : 1005147-23-8

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Description

Z19024498 is a heat sensitizer. Z19024498 inhibits SAFB granule formation under heat stress conditions. Z19024498 enhances heat stress-induced Apoptosis. Z19024498 exerts anticancer activity against cervical cancer in synergy with heat stress[1].

In Vitro

Z19024498 (5 μM; 1 h pre-incubation at 37°C, 1 h co-incubation with 43°C heat stress, followed by 24 h recovery at 37°C without compound) significantly enhances heat stress-induced cell growth inhibition in HeLa cells[1].
Z19024498 (0-20 μM; 1 h pre-incubation at 37°C, 1 h co-incubation with 43°C heat stress) inhibits standalone SAFB granule formation (IC50 = 10.7 μM) and SAFB granule colocalization with HSF1 granules (IC50 = 2.7 μM) in heat-stressed HeLa cells, without altering HSF1 granule formation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z19024498 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa, H1299, AsPC1, HepG2, HEK293T
Concentration: 0-25 μM (GI50 determination); 5 μM (post-heat stress incubation)
Incubation Time: 37 °C for 1 h, followed by incubation at 43 °C for 1 h, followed by 24 h incubation at 37°C with 5 μM compound
Result: Achieved a GI50 of 5.3 μM (37°C) and 3.1 μM (43°C), with a TER of 1.7 in HeLa cells.
Achieved a GI50 of 4.1 μM (37°C) and 1.6 μM (43°C), with a TER of 2.6 in H1299 cells.
Achieved a GI50 of 18.7 μM (37°C) and 15.6 μM (43°C), with a TER of 1.2 in AsPC1 cells.
Achieved a GI50 of 40.8 μM (37°C) and 3.4 μM (43°C), with a TER of 12 in HepG2 cells.
Achieved a GI50 of 10.5 μM (37°C) and 6.0 μM (43°C), with a TER of 1.8 in HEK293T cells.
Produced all TER values >1.0, indicating synergistic enhancement of hyperthermic effects.
In Vivo

Z19024498 (3 mg/kg; i.p.; twice) alone slightly reduces tumor volume and prolongs survival in mice bearing HeLa xenografts, and exerts significant tumor growth inhibitory effects when combined with hyperthermia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c-nu/nu nude mice (6-week-old female; HeLa cell xenograft)[1]
Dosage: 3 mg/kg
Administration: i.p.; twice (days 0 and 8, 1 hour before hyperthermia)
Result: Reduced tumor volume compared with DMSO-treated mice.
Extended lifespan slightly compared with DMSO-treated controls.
Combined with hyperthermia, significantly suppressed tumor growth compared with DMSO, Z19024498 alone, or hyperthermia alone, with significantly reduced tumor volumes on day 14 and significantly lower tumor weight on day 28 compared with hyperthermia alone.
Extended lifespan slightly compared with hyperthermia alone when combined with hyperthermia.
Caused no changes in body weight, indicating minimal to no physiological toxicity.
Molecular Weight

332.23

Formula

C14H19Cl2N3O2
CAS No.
SMILES

O=C(NC1C(C)C(C)CCC1)CN2C(C(Cl)=C(Cl)C=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z190244981005147-23-8Z 19024498Z-19024498Apoptosiscervical cancerSAFB granulesHeLa cellspancreatic adenocarcinomaHSF1 granulesheat shock transcription factor 1apoptosislung cancerxenograft modelsscaffold attachment factor BInhibitorinhibitorinhibit

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