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Cat. No.: HY-P86686

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PR3 Antibody (YA6378)

Name: PR3 Antibody (YA6378)
Brand: MedChemExpress
SKU: HY-P86686
Availability: PreOrder

(Synonyms: ACPA; AGP 7; AGP7; AGP7 serine proteinase; Azurophil Granule Protein 7; C ANCA antigen; C-ANCA antigen; EC 3.4.21.76; Leukocyte proteinase 3; MBN; MBT WEGENER AUTOANTIGEN; Myeloblastin; Neutrophil proteinase 4; NP 4; NP-4; NP4; P29; PR 3; PR-3; Proteinase3; PRTN 3; Prtn3; PRTN3_HUMAN; Serine proteinase neutrophil Wegener granulomatosis autoantigen; Wegener autoantigen.)

PR3 Antibody (YA6378) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PR3.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
IHC-P, IHC-F, IF-Tissue
Reactivity :
Human

Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Conjugation:
Non-conjugated

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:100-500	1:100-500	1:100-500

Product Details

Description

PR3 Antibody (YA6378) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PR3.

Host Rabbit
Clonality Monoclonal
Species Reactivity
Human
Calculated Molecular Weight Predicted band size: 28 kDa

Immunogen

Recombinant human PR3 Protein

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

PR3 serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. Plays a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation^[1]^[2]^[3]^[4]^[5]^[6].
Subcellular Localization

Cytoplasmic granule,Secreted,Cell membrane,Membrane raft
Expression

Tissue_Specificity: Expressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:3198760, PubMed:7897245). Expressed in neutrophils (at protein level) (PubMed:17244676, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:28240246). Expressed in differentiating neutrophils (PubMed:18462208)
Induction: Induced during CSF3/G-CSF-mediated neutrophil differentiation
Subunit

May form dimers (PubMed:28240246)
SwissProt ID

P24158
Gene ID

5657 [NCBI]
Synonyms

ACPA; AGP 7; AGP7; AGP7 serine proteinase; Azurophil Granule Protein 7; C ANCA antigen; C-ANCA antigen; EC 3.4.21.76; Leukocyte proteinase 3; MBN; MBT WEGENER AUTOANTIGEN; Myeloblastin; Neutrophil proteinase 4; NP 4; NP-4; NP4; P29; PR 3; PR-3; Proteinase3; PRTN 3; Prtn3; PRTN3_HUMAN; Serine proteinase neutrophil Wegener granulomatosis autoantigen; Wegener autoantigen.