CB096
Based on 1 Customer Validation
CB096 is an r(G4C2)exp RNA binder with EC50 values of 19 μM, 20 μM and 33 μM. CB096 selectively interacts with the 5′CGG/3′GGC 1×1 GG internal loop motif of folded r(G4C2)exp RNA, alters motif dynamics and closed base pairs, and rescues disease-related pathways. CB096 can be used for research on inherited amyotrophic lateral sclerosis/frontotemporal dementia (c9ALS/FTD).
For research use only. We do not sell to patients.
- Purity: 98.72%
- CAS No.: 108883-90-5
- Formula: C14H11N3O4
- Molecular Weight:285.25
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
r (G4C2)exp RNA refers to a neurotoxic RNA molecule transcribed from the abnormally expanded hexanucleotide repeat sequence (GGGGCC, i.e., G4C2) in the C9orf72 gene[1].
CB096 (100 μM; EC50) potently binds the r (G4C2)8 hairpin RNA, with an EC50 value of 33 μM as determined by the TO1 dye displacement assay[1].
CB096 (25 μM; 24 h) reverses approximately 75% of nucleocytoplasmic transport dysfunction induced by the expression of r (G4C2)66 in HEK293T cells, with its mechanism of action being the inhibition of RAN translation without affecting canonical translation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 108883-90-5
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Appearance Solid
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Molecular Weight 285.25
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Formula C14H11N3O4
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Color Yellow to orange
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SMILES
OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (175.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Ursu A, et al. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020;15(12):3112-3123. [Content Brief]
[2]. Ursu A, et al. A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks. ACS Chem Neurosci. 2021;12(21):4076-4089. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5057 mL | 17.5285 mL | 35.0570 mL | 87.6424 mL |
| 5 mM | 0.7011 mL | 3.5057 mL | 7.0114 mL | 17.5285 mL | |
| 10 mM | 0.3506 mL | 1.7528 mL | 3.5057 mL | 8.7642 mL | |
| 15 mM | 0.2337 mL | 1.1686 mL | 2.3371 mL | 5.8428 mL | |
| 20 mM | 0.1753 mL | 0.8764 mL | 1.7528 mL | 4.3821 mL | |
| 25 mM | 0.1402 mL | 0.7011 mL | 1.4023 mL | 3.5057 mL | |
| 30 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9214 mL | |
| 40 mM | 0.0876 mL | 0.4382 mL | 0.8764 mL | 2.1911 mL | |
| 50 mM | 0.0701 mL | 0.3506 mL | 0.7011 mL | 1.7528 mL | |
| 60 mM | 0.0584 mL | 0.2921 mL | 0.5843 mL | 1.4607 mL | |
| 80 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 1.0955 mL | |
| 100 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL | 0.8764 mL |
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