2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. CB096

CB096 is an r(G4C2)exp RNA binder with EC50 values of 19 μM, 20 μM and 33 μM. CB096 selectively interacts with the 5′CGG/3′GGC 1×1 GG internal loop motif of folded r(G4C2)exp RNA, alters motif dynamics and closed base pairs, and rescues disease-related pathways. CB096 can be used for research on inherited amyotrophic lateral sclerosis/frontotemporal dementia (c9ALS/FTD).

For research use only. We do not sell to patients.

CB096

CB096 Chemical Structure

CAS No. : 108883-90-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
100 mg In-stock
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Based on 1 publication(s) in Google Scholar

CB096 Related Antibodies

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Description

CB096 is an r(G4C2)exp RNA binder with EC50 values of 19 μM, 20 μM and 33 μM. CB096 selectively interacts with the 5′CGG/3′GGC 1×1 GG internal loop motif of folded r(G4C2)exp RNA, alters motif dynamics and closed base pairs, and rescues disease-related pathways. CB096 can be used for research on inherited amyotrophic lateral sclerosis/frontotemporal dementia (c9ALS/FTD)[1][2].

In Vitro

r (G4C2)exp RNA refers to a neurotoxic RNA molecule transcribed from the abnormally expanded hexanucleotide repeat sequence (GGGGCC, i.e., G4C2) in the C9orf72 gene[1].
CB096 (100 μM; EC50) potently binds the r (G4C2)8 hairpin RNA, with an EC50 value of 33 μM as determined by the TO1 dye displacement assay[1].
CB096 (25 μM; 24 h) reverses approximately 75% of nucleocytoplasmic transport dysfunction induced by the expression of r (G4C2)66 in HEK293T cells, with its mechanism of action being the inhibition of RAN translation without affecting canonical translation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB096 Related Antibodies
Molecular Weight

285.25

Formula

C14H11N3O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (175.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5057 mL 17.5285 mL 35.0570 mL
5 mM 0.7011 mL 3.5057 mL 7.0114 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5057 mL 17.5285 mL 35.0570 mL 87.6424 mL
5 mM 0.7011 mL 3.5057 mL 7.0114 mL 17.5285 mL
10 mM 0.3506 mL 1.7528 mL 3.5057 mL 8.7642 mL
15 mM 0.2337 mL 1.1686 mL 2.3371 mL 5.8428 mL
20 mM 0.1753 mL 0.8764 mL 1.7528 mL 4.3821 mL
25 mM 0.1402 mL 0.7011 mL 1.4023 mL 3.5057 mL
30 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9214 mL
40 mM 0.0876 mL 0.4382 mL 0.8764 mL 2.1911 mL
50 mM 0.0701 mL 0.3506 mL 0.7011 mL 1.7528 mL
60 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.4607 mL
80 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0955 mL
100 mM 0.0351 mL 0.1753 mL 0.3506 mL 0.8764 mL
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CB096 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB096108883-90-5CB 096CB-096DNA/RNA SynthesisHEK293T cellsamyotrophic lateral sclerosis/frontotemporal dementiaRAN translationCy5-r(CGG) 16 RNAr(G4C2 )exp RNAc9ALS/FTDr(G4C2)8 hairpin RNAstress granulespoly(GP) dipeptide repeat protein5′CGG/3′GGC 1×1 GG internal loop motif
Inhibitorinhibitorinhibit

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