108883-90-5
108883-90-5
Chemical Structure
CB096
- CAS No.: 108883-90-5
- Formula:C14H11N3O4
- Molecular Weight:285.25
IUPAC Name: 2-methoxy-4-(6-nitro-1H-benzo[d]imidazol-2-yl)phenol
InChIKey: LSNPOGOZVAHETR-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
Biological Activity: CB096 is an r(G4C2)exp RNA binder with EC50 values of 19 μM, 20 μM and 33 μM. CB096 selectively interacts with the 5′CGG/3′GGC 1×1 GG internal loop motif of folded r(G4C2)exp RNA, alters motif dynamics and closed base pairs, and rescues disease-related pathways. CB096 can be used for research on inherited amyotrophic lateral sclerosis/frontotemporal dementia (c9ALS/FTD)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CB096 | 98.72% | CB096 is an r(G4C2)exp RNA binder with EC50 values of 19 μM, 20 μM and 33 μM. CB096 selectively interacts with the 5′CGG/3′GGC 1×1 GG internal loop motif of folded r(G4C2)exp RNA, alters motif dynamics and closed base pairs, and rescues disease-related pathways. CB096 can be used for research on inherited amyotrophic lateral sclerosis/frontotemporal dementia (c9ALS/FTD). | ||||||||||||||||||||
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References
- [1]. Ursu A, et al. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020;15(12):3112-3123. [Content Brief]
- [2]. Ursu A, et al. A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks. ACS Chem Neurosci. 2021;12(21):4076-4089. [Content Brief]
