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Results for "

phospholipase A2 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phospholipase (100) Acetyl-CoA Carboxylase (1) Akt (2) Antibiotic (3) AP-1 (2) Apoptosis (6) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (1) Carbonic Anhydrase (4) COX (7) DAGL (1) Drug Derivative (1) Drug Isomer (1) Endogenous Metabolite (4) Environmental Pollutants (2) ERK (2) FAP (1) Fungal (4) HDAC (2) HIV Protease (2) Integrin (4) Isotope-Labeled Compounds (3) Leukotriene Receptor (1) Lipase (1) Lipoxygenase (2) MAGL (1) NADPH Oxidase (2) NF-κB (2) p38 MAPK (2) Phosphatase (4) Prostaglandin Receptor (4) Reactive Oxygen Species (ROS) (3) Reference Standards (10) TRP Channel (1) Tyrosinase (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (13) Endocrinology (2) Infection (11) Inflammation/Immunology (69) Metabolic Disease (12) Neurological Disease (16)

By Targets:

Phospholipase (100)

Acetyl-CoA Carboxylase (1)

Akt (2)

Antibiotic (3)

AP-1 (2)

Apoptosis (6)

Autophagy (2)

Bacterial (2)

Biochemical Assay Reagents (1)

Carbonic Anhydrase (4)

COX (7)

DAGL (1)

Drug Derivative (1)

Drug Isomer (1)

Endogenous Metabolite (4)

Environmental Pollutants (2)

ERK (2)

FAP (1)

Fungal (4)

HDAC (2)

HIV Protease (2)

Integrin (4)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (1)

Lipase (1)

Lipoxygenase (2)

MAGL (1)

NADPH Oxidase (2)

NF-κB (2)

p38 MAPK (2)

Phosphatase (4)

Prostaglandin Receptor (4)

Reactive Oxygen Species (ROS) (3)

Reference Standards (10)

TRP Channel (1)

Tyrosinase (2)

By Research Areas:

Cancer (11)

Cardiovascular Disease (13)

Endocrinology (2)

Infection (11)

Inflammation/Immunology (69)

Metabolic Disease (12)

Neurological Disease (16)

112

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Phospholipase PNPLA3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118628

(E/Z)-BML264 5+ Cited Publications N-(p-Amylcinnamoyl) anthranilic acid; ACA	Phospholipase TRP Channel	Cardiovascular Disease
(E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A₂ (PLA₂) inhibitor and TRP channel blocker . (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia .

HY-108611

AACOCF3 4 Publications Verification Arachidonyl trifluoromethyl ketone	Phospholipase	Cardiovascular Disease
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa *cytosolic phospholipase* A2 (cPLA2)*. AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits* glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .

HY-13402

Varespladib Maximum Cited Publications 9 Publications Verification LY315920	Phospholipase	Inflammation/Immunology
Varespladib (LY315920) is a potent and selective *group IIA, secretory phospholipase* A₂ (sPLA₂)** inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-N7036

Rhamnetin 1 Publications Verification	Phospholipase HDAC Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-17448

Varespladib methyl 1 Publications Verification A-002; LY333013	Phospholipase	Inflammation/Immunology
Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).

HY-107411

Bromoenol lactone 3 Publications Verification (6E)-Bromoenol lactone	Phospholipase	Inflammation/Immunology
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of *calcium-independent phospholipase* A₂ (iPLA₂β) with an IC₅₀** value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca ²⁺ influx .

HY-115403

FKGK18 1 Publications Verification	Phospholipase Apoptosis	Metabolic Disease
FKGK18 is a selective *group VIA calcium-independent phospholipase* A₂ (GVIA iPLA₂)** inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC₅₀s of 50 nM and 3 μM for iPLA₂β and iPLA₂γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes .

HY-108607

PACOCF3 Palmityltrifluoromethylketone	Phospholipase	Inflammation/Immunology
PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC₅₀ of 3.8 μM. PACOCF3 alters Ca ²⁺ signaling in renal tubular cells .

HY-W012595

Benzylideneacetone Benzalacetone	Environmental Pollutants Antibiotic Endogenous Metabolite Phospholipase Bacterial Tyrosinase	Infection Metabolic Disease Inflammation/Immunology
Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-11059

KH064	Phospholipase	Inflammation/Immunology
KH064, a D-tyrosine derivative, is an orally active, potent *secretory phospholipase* A₂ (sPLA₂)** inhibitor with an IC₅₀ of 29 nM for human nonpancreatic secretory PLA₂ isoform IIa (hnpsPLA₂-IIa). KH064 has anti-inflammatory activity .

HY-102004

Rilapladib 3 Publications Verification SB 659032	Phospholipase	Neurological Disease Inflammation/Immunology
Rilapladib (SB 659032) is a selective Lp-PLA₂ (lipoprotein-associated phospholipase A₂) inhibitor with an IC₅₀ of 230 pM . Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist .

HY-19151

Fuzapladib IS-741	Integrin Phospholipase	Inflammation/Immunology
Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .

HY-N7327

Ochnaflavone	Phospholipase	Inflammation/Immunology
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-156041

Lysophosphatidylethanolamines, egg Lyso-PE (egg); LPE (egg); L-α-lysophosphatidylethanolamine	Endogenous Metabolite	Metabolic Disease
Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (HY-12031A) and PD 98059 (HY-12028) and the EGFR inhibitor AG-1478 (HY-13524).1 LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.3 This product contains lysophosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position.

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-14952

Giripladib PLA-695	Phospholipase	Inflammation/Immunology Cancer
Giripladib (PLA-695) is a indole-based inhibitor of *cytosolic phospholipase* A₂ (cPLA₂)**. Giripladib can be used for osteoarthritis and breast cancer research .

HY-101015A

OBAA	Phospholipase Apoptosis	Inflammation/Immunology
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM .

HY-13402A

Varespladib sodium Maximum Cited Publications 9 Publications Verification LY315920 sodium	Phospholipase	Inflammation/Immunology
Varespladib sodium (LY315920 sodium) is a potent and selective *group IIA, secretory phospholipase* A₂ (sPLA₂)** inhibitor with an IC₅₀ of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-W100403

Choline tosylate Choline p-toluenesulfonate	Phospholipase	Others
Choline tosylate (Choline p-toluenesulfonate) is an intermediate and also a substrate of choline acetyltransferase (CHAT). Choline tosylate inhibits phospholipase A2 and phospholipase C .

HY-122756

N-Palmitoyl-l-leucine GK144	Phospholipase	Inflammation/Immunology
N-Palmitoyl-l-leucine (GK144) is a *secreted phospholipases* A₂** inhibitor. N-Palmitoyl-l-leucine can be used for inflammatory diseases .

HY-120441

CAY10590 GK115	Phospholipase Prostaglandin Receptor	Inflammation/Immunology
CAY10590 (GK115) is an inhibitor of *secreted phospholipase* A₂ (sPLA₂**) and can be used for the research of chronic inflammatory kidney diseases .

HY-145653

GSK2647544	Phospholipase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages .

HY-W012595A

trans-Benzylideneacetone trans-Benzalacetone	Environmental Pollutants Phospholipase	Inflammation/Immunology
trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant .

HY-107393

LY-311727	Phospholipase	Inflammation/Immunology
LY-311727 is a potent *secretory non-pancreatic phospholipase* A₂ (sPLA₂)** inhibitor (IC₅₀ <1 μM for group IIA sPLA₂). sPLA₂ is an important proinflammatory enzyme .

HY-17485

Alminoprofen 1 Publications Verification EB-382	Phospholipase COX	Inflammation/Immunology
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both *secretory phospholipase* A₂ (sPLA₂) and COX-2** .

HY-19757

Lp-PLA2-IN-1	Phospholipase	Cardiovascular Disease Neurological Disease
Lp-PLA2-IN-1 is a potent *Lipoprotein-associated phospholipase* A2 (Lp-PLA2)** inhibitor. Lp-PLA2-IN-1 has the potential for atherosclerosis, Alzheimer's disease research .

HY-116301

CAY10502	Phospholipase	Inflammation/Immunology
CAY10502 is a potent, calcium-dependent *cytosolic phospholipase* A2 α** (cPLA₂α) inhibitor with an IC₅₀ of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases .

HY-19151A

Fuzapladib sodium IS-741 sodium	Integrin Phospholipase	Inflammation/Immunology
Fuzapladib (IS-741) sodium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib sodium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib sodium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .

HY-120078

AZD2716	Phospholipase
AZD2716 is a selective sPLA₂ (secretory phospholipase A2) inhibitor. AZD2716 significantly reduces the production of pro-inflammatory lipids by inhibiting sPLA₂-IIa (IC₅₀ = 10 nM), sPLA₂-V (IC₅₀ = 40 nM), and sPLA₂-X (IC₅₀ = 400 nM), thereby decreasing macrophage activation and foam cell formation. AZD2716 is promising for studying mechanisms related to atherosclerosis and inflammatory diseases associated with sPLA₂ .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-129944

MJ33-OH	Phospholipase	Inflammation/Immunology
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .

HY-125157

Me-Indoxam	Phospholipase	Inflammation/Immunology
Me-Indoxam is a potent and cell-impermeable secreted phospholipase A₂ (sPLA₂) inhibitor .

HY-145384

ROC-0929	Phospholipase	Inflammation/Immunology
ROC-0929 (compound 13a) is a potent and selective inhibitor of *secreted phospholipases* A₂ (sPLA₂s) with an IC₅₀ of 80 nM, specially targeting hGX*. ROC-0929 inhibits* the phosphorylation of ERK1/2 and p-38. *Secreted phospholipases* A2 (sPLA2s)** are a family of disulfide-rich, Ca ²⁺-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .

HY-168765

LY433771 LSN433771	Phospholipase	Cardiovascular Disease
LY433771 (LSN433771) (Compound 8) is a type X secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ value of 3 nM, which can be used in the study of cardiovascular diseases .

HY-116018

FKGK11	Phospholipase	Neurological Disease Inflammation/Immunology Cancer
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis .

HY-N2330

Lipstatin	Lipase	Metabolic Disease
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-W127380

Arachidonoyl thio-PC	Biochemical Assay Reagents	Others
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-19920

AVX001 AKH-217	Phospholipase	Inflammation/Immunology
AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis .

HY-N1450

Aristolochic acid C	Phospholipase	Cancer
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A₂ (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-N8610

Uralsaponin D	Phosphatase	Inflammation/Immunology
Uralsaponin D is a saponin that can be isolated from Glycyrrhiza inflata. Uralsaponin D inhibits phospholipase A2 (PLA₂) with an IC₅₀ value of 32.2 μM .

HY-153561

Lp-PLA2-IN-15	Phospholipase	Neurological Disease
Lp-PLA2-IN-15 (example 2) is a lipoprotein-associated phospholipase A2 (Lp-PLA 2) inhibitor, which can be used in the research of Alzheimer's disease, etc .

HY-129944A

MJ33-OH lithium	Phospholipase	Inflammation/Immunology
MJ33-OH lithium is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .

HY-113560

Plipastatin B1	Antibiotic Fungal Phospholipase	Infection
Plipastatin B1 is a lipopeptide antibiotic, an inhibitor of phospholipase A₂ (PLA2), which has antifungal activity .

HY-128762

ML256	Phospholipase	Cancer
ML256 is a covalent *lipoprotein-associated phospholipase* A2 (Lp-PLA2** inhibitor. ML256 can be used for the study of neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS .

HY-W396889

(R)-N-(1-Hydroxypropan-2-yl)palmitamide	Phospholipase	Inflammation/Immunology
(R)-N-(1-Hydroxypropan-2-yl)palmitamide (compound 24) is a substrate analog inhibitor of phospholipase A2 .

HY-118725

Luffariellolide	Phospholipase	Inflammation/Immunology
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-23909

7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid DEDA	Phospholipase	Inflammation/Immunology
7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA), a *phospholipase* inhibitor, is a non-metabolizable analog of arachidonic or eicosadienoic acid. 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA) inhibits P388D1 cell phospholipase A₂ (PLA₂) (IC₅₀ = 16 µM) and snake venom PLA₂ (IC₅₀ = 14 µM) .

HY-101015

(2E)-OBAA	Phospholipase Apoptosis	Inflammation/Immunology
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC₅₀ of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei, with an IC₅₀ of 0.4 μM .

HY-125986

GK187	Phospholipase	Neurological Disease
GK187 is a potent and selective *Group VIA calcium-independent phospholipase* A₂ (GVIA iPLA₂)** inhibitor with an X_I(50) value of 0.0001. GK187 can be used for researching various neurological disorders . ^{[The X_I(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]}

HY-120621

BMS-229724	Phospholipase	Inflammation/Immunology
BMS-229724 is an orally active and tight-binding cytosolic phospholipase A₂ (cPLA₂) inhibitor with an IC₅₀ of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation .

Cat. No.	Product Name	Type

HY-W100403

Choline tosylate Choline p-toluenesulfonate	Biochemical Assay Reagents
Choline tosylate (Choline p-toluenesulfonate) is an intermediate and also a substrate of choline acetyltransferase (CHAT). Choline tosylate inhibits phospholipase A2 and phospholipase C .

HY-W127380

Arachidonoyl thio-PC

Biochemical Assay Reagents

Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

Cat. No.	Product Name	Target	Research Area

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-113560

Plipastatin B1	Antibiotic Fungal Phospholipase	Infection
Plipastatin B1 is a lipopeptide antibiotic, an inhibitor of phospholipase A₂ (PLA2), which has antifungal activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7036

Rhamnetin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification	Phospholipase HDAC Apoptosis
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-W012595

Benzylideneacetone Benzalacetone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Phospholipase Bacterial Tyrosinase
Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-N1393

2-Methoxybenzoic acid NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Carbonic Anhydrase Phospholipase
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether) is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-N7327

Ochnaflavone	Structural Classification Flavonoids Ochna atropurpurea DC. Plants Biflavones Source Classification	Phospholipase
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-W012595A

trans-Benzylideneacetone trans-Benzalacetone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Phospholipase
trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant .

HY-W612338

9-Oxononanoic acid 9-ONA	Structural Classification Arachis hypogaea L. Leguminosae Ketones, Aldehydes, Acids Plants Source Classification	Acetyl-CoA Carboxylase
9-Oxononanoic acid (9-ONA) is an orally active acetyl-CoA carboxylase inhibitor. 9-Oxononanoic acid inhibits acetyl-CoA carboxylase via accumulation of long-chain acyl-CoA. 9-Oxononanoic acid increases carnitine palmitoyltransferase, isocitrate dehydrogenase and glucose 6-phosphate dehydrogenase activity to elevate β-oxidation and support NADPH (HY-113324) supplyactivity. 9-Oxononanoic acid stimulates phospholipase A2 activity via post-translational, non-transcriptional mechanisms. 9-Oxononanoic acid can be used for the research of atherothrombosis .

HY-N2330

Lipstatin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Lipase
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-N1450

Aristolochic acid C	Monophenols other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Phospholipase
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A₂ (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-N8610

Uralsaponin D	Triterpenes Leguminosae Glycyrrhiza inflata Batal. Terpenoids Plants Source Classification	Phosphatase
Uralsaponin D is a saponin that can be isolated from Glycyrrhiza inflata. Uralsaponin D inhibits phospholipase A2 (PLA₂) with an IC₅₀ value of 32.2 μM .

HY-118725

Luffariellolide	Natural Products Classification of Application Fields Animals Disease Research Fields Inflammation/Immunology Source Classification	Phospholipase
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-N14050

Cinatrin A	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin A has the activity of inhibiting phospholipase A2 .

HY-N14101

Cinatrin B	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin B has the activity of inhibiting phospholipase A2 .

HY-116671

Folipastatin	Monophenols Microorganisms Classification of Application Fields Other Diseases Phenols Disease Research Fields Source Classification	Phospholipase
Folipastatin is a potent inhibitor of phospholipase A2 with an IC₅₀ of 39 μM. Folipastatin is a new depsidone compound from Aspergillus unguis .

HY-N14103

Cinatrin C1	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin C1 is a phospholipase A2 (PLA2) inhibitor that can be extracted from Circinotrichum falcatisporum RF-641 .

HY-N14104

Cinatrin C2	Microorganisms Antibiotics Other Antibiotics Source Classification	Phospholipase
Cinatrin C2 is a phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 800 μM and can be extracted from Circinotrichum falcatisporum RF-641 .

HY-N14105

Cinatrin C3	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin C3 is a phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 μM and can be extracted from Circinotrichum falcatisporum RF-641 .

HY-N1450R

Aristolochic acid C (Standard)	Structural Classification Monophenols other families Phenols Plants Source Classification	Reference Standards Phospholipase
Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-N7036R

Rhamnetin (Standard)	Flavonols Structural Classification Flavonoids Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Source Classification	Reference Standards Phospholipase HDAC Apoptosis
Rhamnetin (Standard) is the analytical standard of Rhamnetin. This product is intended for research and analytical applications. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-N16481

Parameritannin A-1	Apocynaceae Structural Classification Phenols Polyphenols Parameria laevigata (Juss.) Moldenke Plants Source Classification	COX Phospholipase
Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A₂ (PLA₂) .

HY-W012595AR

trans-Benzylideneacetone (Standard) trans-Benzalacetone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Phospholipase
trans-Benzylideneacetone (Standard) is the analytical standard of trans-Benzylideneacetone. This product is intended for research and analytical applications. trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant[1].

HY-W012595R

Benzylideneacetone (Standard) Benzalacetone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Antibiotic Bacterial Tyrosinase Phospholipase
Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-N1393R

2-Methoxybenzoic acid (Standard) NSC 3778 (Standard); O-Methylsalicylic acid (Standard); Salicylic acid methyl ether (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Carbonic Anhydrase Phospholipase
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether) (Standard) is the analytical standard of 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-N16849

Myristinin A YM 26567-1	Structural Classification Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants Source Classification	COX Prostaglandin Receptor Fungal
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC₅₀ of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC₅₀ of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis .

HY-N16865

Myristinin B/C	Structural Classification Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants Source Classification	COX Prostaglandin Receptor Fungal
Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit COX-2 activity with an IC₅₀ of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candida albicans with an IC₅₀ of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis .

Cat. No.	Product Name	Chemical Structure

HY-13402S

Varespladib-d7

Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-N1393S

2-Methoxybenzoic acid-13C6

2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether)- ¹³C₆ is the ¹³C-labeled 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-N1393S1

2-Methoxybenzoic acid-d3

2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether)-d₃ is deuterium-labeled 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

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phospholipase A2 inhibitor

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