1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. COX
    Lipoxygenase
    Phospholipase
  3. LY 178002

LY 178002 

Cat. No.: HY-101579
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LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

For research use only. We do not sell to patients.

LY 178002 Chemical Structure

LY 178002 Chemical Structure

CAS No. : 107889-32-7

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Description

LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

IC50 & Target[1]

5-LPO

0.6 μM (IC50)

PLA2

6.3 μM (IC50)

FCO

4.2 μM (IC50)

Cyclooxygenase

 

In Vitro

LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC50s of 0.1, 6.3 and 4.2 μM [1].

In Vivo

LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1].

Molecular Weight

319.46

Formula

C₁₈H₂₅NO₂S

CAS No.

107889-32-7

SMILES

O=C1NCS/C1=C/C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LY 178002LY178002LY-178002COXLipoxygenasePhospholipaseCyclooxygenaseLOXInhibitorinhibitorinhibit

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