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Cat. No.: HY-P10053

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sPLA2-IIA Inhibitor

sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids.

For research use only. We do not sell to patients.

CAS No.: 236394-37-9
Formula: C₄₁H₅₀N₈O₆
Molecular Weight:750.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

sPLA2-IIA Inhibitor Chemical Structure

CAS No.: 236394-37-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Phospholipase Isoforms :

Chemical Information

CAS No. 236394-37-9
Molecular Weight 750.89
Formula C₄₁H₅₀N₈O₆
Sequence

Cyclo({Nal}-Leu-Ser-{Nal}-Arg)
Sequence Shortening

Cyclo({Nal}-LS-{Nal}-R)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim RR, et al. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A2. Proteins. 2017;85(5):827-842. doi:10.1002/prot.25235

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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sPLA2-IIA Inhibitor

All Phospholipase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

sPLA2-IIA Inhibitor Related Classifications

HY-P10053 Related Classifications