236394-37-9
Chemical Structure
sPLA2-IIA Inhibitor
- CAS No.: 236394-37-9
- Formula:C41H50N8O6
- Molecular Weight:750.89
InChIKey: MTWYMBFLNQUYAM-ZZTWKDBPSA-N
SMILES: O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC(C)C)=O)CO)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)CCCNC(N)=N)N[C@H]1CC4=CC5=C(C=CC=C5)C=C4
Biological Activity: sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids[1].
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sPLA2-IIA Inhibitor | sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids. | |||||||||||||||||||||
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Keywords
