2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. PACOCF3

PACOCF3  (Synonyms: Palmityltrifluoromet​hylketone)

Cat. No.: HY-108607 Purity: ≥98.0%
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PACOCF3 (Palmityltrifluoromet​hylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.

For research use only. We do not sell to patients.

PACOCF3 Chemical Structure

PACOCF3 Chemical Structure

CAS No. : 141022-99-3

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Based on 1 publication(s) in Google Scholar

PACOCF3 Related Antibodies

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Description

PACOCF3 (Palmityltrifluoromet​hylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells[1][2].

IC50 & Target[1]

PLA2

3.8 μM (IC50)

In Vitro

At a concentration of 20 μM, PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca2+]i), but at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca2+]i by activating extracellular Ca2+ entry which is partly suppressed by 50 μM La3+[2].
The effect of PACOCF3 is abolished by removal of extracellular Ca2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca2+]i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca2+ influx without affecting internal Ca2+ release[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PACOCF3 Related Antibodies
Molecular Weight

308.42

Formula

C17H31F3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (108.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2423 mL 16.2117 mL 32.4233 mL
5 mM 0.6485 mL 3.2423 mL 6.4847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2423 mL 16.2117 mL 32.4233 mL 81.0583 mL
5 mM 0.6485 mL 3.2423 mL 6.4847 mL 16.2117 mL
10 mM 0.3242 mL 1.6212 mL 3.2423 mL 8.1058 mL
15 mM 0.2162 mL 1.0808 mL 2.1616 mL 5.4039 mL
20 mM 0.1621 mL 0.8106 mL 1.6212 mL 4.0529 mL
25 mM 0.1297 mL 0.6485 mL 1.2969 mL 3.2423 mL
30 mM 0.1081 mL 0.5404 mL 1.0808 mL 2.7019 mL
40 mM 0.0811 mL 0.4053 mL 0.8106 mL 2.0265 mL
50 mM 0.0648 mL 0.3242 mL 0.6485 mL 1.6212 mL
60 mM 0.0540 mL 0.2702 mL 0.5404 mL 1.3510 mL
80 mM 0.0405 mL 0.2026 mL 0.4053 mL 1.0132 mL
100 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.8106 mL
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PACOCF3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PACOCF3141022-99-3Palmityltrifluoromet​hylketonePACOCF 3PACOCF-3PhospholipaseCa2+ signalingphospholipase A2 inhibitorInhibitorinhibitorinhibit

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