2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Lp-PLA2-IN-4

Lp-PLA2-IN-4 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-4 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2021228159A1, compound 38).

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Lp-PLA2-IN-4 Chemical Structure

Lp-PLA2-IN-4 Chemical Structure

CAS No. : 2738877-91-1

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Lp-PLA2-IN-4 Related Antibodies

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Description

Lp-PLA2-IN-4 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-4 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2021228159A1, compound 38)[1].

IC50 & Target

Lp-PLA2[1]
Molecular Weight

495.40

Formula

C23H18F5N3O4
CAS No.
SMILES

O=C1N2C(N3C[C@@H](OCC3)C2)=CC(OCC4=CC(F)=C(C(F)=C4)OC5=CC(C(F)(F)F)=CC=C5)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lp-PLA2-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lp-PLA2-IN-42738877-91-1PhospholipasePAF-AHphospholipase A2 enzymelipoprotein lipidsphospholipidatherosclerosisAlzheimer's diseaseInhibitorinhibitorinhibit

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