1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Bromoenol lactone

Bromoenol lactone (Synonyms: (6E)-Bromoenol lactone)

Cat. No.: HY-107411
Handling Instructions

Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.

For research use only. We do not sell to patients.

Bromoenol lactone Chemical Structure

Bromoenol lactone Chemical Structure

CAS No. : 88070-98-8

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Description

Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].

IC50 & Target[1][2]

PLA2

7 μM (IC50)

In Vitro

In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilised mast cells where Ca2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signalling, both the release from internal stores and sustained elevation due to Ca2+ influx[1].

Molecular Weight

317.18

Formula

C₁₆H₁₃BrO₂

CAS No.

88070-98-8

SMILES

O=C1C(C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bromoenol lactone(6E)-Bromoenol lactonePhospholipaseInhibitorinhibitorinhibit

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Bromoenol lactone
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