1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Bromoenol lactone

Bromoenol lactone (Synonyms: (6E)-Bromoenol lactone)

Cat. No.: HY-107411 Purity: 98.18%
Handling Instructions

Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.

For research use only. We do not sell to patients.

Bromoenol lactone Chemical Structure

Bromoenol lactone Chemical Structure

CAS No. : 88070-98-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 158 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 316 In-stock
Estimated Time of Arrival: December 31
50 mg USD 556 In-stock
Estimated Time of Arrival: December 31
100 mg USD 960 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Bromoenol lactone:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Bromoenol lactone

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Description

Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].

IC50 & Target[1][2]

PLA2

7 μM (IC50)

In Vitro

In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilised mast cells where Ca2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signalling, both the release from internal stores and sustained elevation due to Ca2+ influx[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

317.18

Formula

C16H13BrO2

CAS No.
SMILES

O=C1C(C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (157.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1528 mL 15.7639 mL 31.5278 mL
5 mM 0.6306 mL 3.1528 mL 6.3056 mL
10 mM 0.3153 mL 1.5764 mL 3.1528 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (7.88 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.88 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.88 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.18%

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Bromoenol lactone
Cat. No.:
HY-107411
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