88070-98-8
88070-98-8
Chemical Structure
Bromoenol lactone
Synonym(s): (6E)-Bromoenol lactone
- CAS No.: 88070-98-8
- Formula:C16H13BrO2
- Molecular Weight:317.18
IUPAC Name: (E)-6-(bromomethylene)-3-(naphthalen-1-yl)tetrahydro-2H-pyran-2-one
InChIKey: BYUCSFWXCMTYOI-ZRDIBKRKSA-N
SMILES: O=C1C(C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br
Biological Activity: Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bromoenol lactone | 99.59% | Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. | ||||||||||||||||||||
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References
- [1]. Fensome-Green A, et al. Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. Cell Calcium. 2007 Feb;41(2):145-53. [Content Brief]
- [2]. Takuma T, et al. Role of Ca2+-independent phospholipase A2 in exocytosis of amylase from parotid acinar cells. J Biochem. 1997 Jun;121(6):1018-24. [Content Brief]
