(R)-Bromoenol lactone
(R)-Bromoenol lactone ((R,E)-Bromoenol lactone) is an isomer of Bromoenol lactone (HY-107411). (R)-Bromoenol lactone acts as a selective inhibitor of microsomal calcium-independent phospholipase A2γ (iPLA2γ). (R)-Bromoenol lactone induces mild activation of p38 mitogen-activated protein kinase in prostate cancer cells, resulting in slight increases in the expressions of phosphorylated p53, total p53 and p21. (R)-Bromoenol lactone is applicable to prostate cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 478288-90-3
- Formula: C16H13BrO2
- Molecular Weight:317.18
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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p38 |
PLA2 |
(R)-Bromoenol lactone (R-BEL) (5 μM; 9 h) slightly upregulates the expression levels of phosphorylated p53 (Ser15), total p53 and p21 in human prostate cancer LNCaP cells[1].
(R)-Bromoenol lactone (5 μM; 2 h) slightly upregulates the expression of phosphorylated p38 and slightly increases the production of active substances in LNCaP and PC-3 human prostate cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:p53-positive human prostate cancer LNCaP cells
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Concentration:5 μM
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Incubation Time:9 h
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Result:Caused only a slight increase in phosphorylated p53 (Ser15), total p53, and p21 protein expression relative to untreated control cells.
Resulted in a significantly lower increase than that induced by racemic bromoenol lactone or S-bromoenol lactone.
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Cell Line:p53-positive human prostate cancer LNCaP cells, p53-negative human prostate cancer PC-3 cells
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Concentration:5 μM
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Incubation Time:2 h
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Result:Caused only a slight increase in phosphorylated p38 protein expression relative to untreated control cells.
Resulted in a significantly lower increase than that induced by racemic bromoenol lactone or S-bromoenol lactone.
Chemical Information
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CAS No. 478288-90-3
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Appearance Liquid
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Molecular Weight 317.18
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Formula C16H13BrO2
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Color Colorless to light yellow
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SMILES
O=C1[C@@H](C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br
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Synonyms
(R,E)-Bromoenol lactone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-Bromoenol lactone Related Classifications
HY-117068 Related Classifications
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- (R)-Bromoenol lactone
- 478288-90-3
- (R,E)-Bromoenol lactone
- Phospholipase
- p38 MAPK
- MDM-2/p53
- prostate cancer cells
- reactive species
- p53
- iPLA2γ
- microsomal calcium-independent phospholipase A2γ
- PC-3 human prostate cancer cells
- phosphorylated-p53
- p21
- p38 mitogen-activated protein kinase
- LNCaP human prostate cancer cells
- Inhibitor
- inhibitor
- inhibit