(S)-Bromoenol lactone
Based on 1 Customer Validation
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 μM.
The product specifications provided below refer solely to the active content of (S)-Bromoenol lactone.
For research use only. We do not sell to patients.
- Purity : 99.1%
- CAS No.: 478288-94-7
- Formula: C16H13BrO2
- Molecular Weight:317.18
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Storage:
Solution, -20°C, 2 years
All Phospholipase Isoforms
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Biological Activity
Description
The product specifications provided below refer solely to the active content of (S)-Bromoenol lactone.
IC50 & Target
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PLA2 |
Chemical Information
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CAS No. 478288-94-7
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Appearance Liquid
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Molecular Weight 317.18
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Formula C16H13BrO2
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Color Colorless to light yellow
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SMILES
O=C1[C@H](C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br
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Synonyms
(S)-BEL; (S,E)-Bromoenol lactone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277(36):32807-14. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)