478288-94-7
Chemical Structure
(S)-Bromoenol lactone
Synonym(s): (S)-BEL; (S,E)-Bromoenol lactone
- CAS No.: 478288-94-7
- Formula:C16H13BrO2
- Molecular Weight:317.18
IUPAC Name: (S,E)-6-(bromomethylene)-3-(naphthalen-1-yl)tetrahydro-2H-pyran-2-one
InChIKey: BYUCSFWXCMTYOI-PABFRNLHSA-N
SMILES: O=C1[C@H](C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br
Biological Activity:
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 μM[1].
The product specifications provided below refer solely to the active content of (S)-Bromoenol lactone.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Bromoenol lactone | 99.1% | (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 μM. The product specifications provided below refer solely to the active content of (S)-Bromoenol lactone. |
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(S)-Bromoenol lactone-d7 | (S)-Bromoenol lactone-d7 is the deuterium labeled (S)-Bromoenol lactone. | |||||||||||||||||||||
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Similarity Score 1.00
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References
- [1]. Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277(36):32807-14. [Content Brief]
