N-Palmitoyl-l-leucine (Synonyms: GK144)

Cat. No.: HY-122756 Purity: 99.98%: Data Sheet
COA

SDS
Handling Instructions
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N-Palmitoyl-l-leucine (GK144) is a secreted phospholipases A₂ inhibitor. N-Palmitoyl-l-leucine can be used for inflammatory diseases.

For research use only. We do not sell to patients.

N-Palmitoyl-l-leucine Chemical Structure

CAS No. : 14379-42-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

N-Palmitoyl-l-leucine (GK144) is a secreted phospholipases A₂ inhibitor. N-Palmitoyl-l-leucine can be used for inflammatory diseases^[1].

IC₅₀ & Target^[1]

sPLA2

Molecular Weight

369.58

Formula

C₂₂H₄₃NO₃

CAS No.

14379-42-1

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CC(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (270.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7058 mL	13.5289 mL	27.0577 mL
5 mM	0.5412 mL	2.7058 mL	5.4115 mL
10 mM	0.2706 mL	1.3529 mL	2.7058 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (239 KB) HNMR (257 KB) LCMS (327 KB)

Handling Instructions (2659 KB)

References

[1]. Mouchlis VD, et al. Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorg Med Chem. 2011 Jan 15;19(2):735-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7058 mL	13.5289 mL	27.0577 mL	67.6444 mL
	5 mM	0.5412 mL	2.7058 mL	5.4115 mL	13.5289 mL
	10 mM	0.2706 mL	1.3529 mL	2.7058 mL	6.7644 mL
	15 mM	0.1804 mL	0.9019 mL	1.8038 mL	4.5096 mL
	20 mM	0.1353 mL	0.6764 mL	1.3529 mL	3.3822 mL
	25 mM	0.1082 mL	0.5412 mL	1.0823 mL	2.7058 mL
	30 mM	0.0902 mL	0.4510 mL	0.9019 mL	2.2548 mL
	40 mM	0.0676 mL	0.3382 mL	0.6764 mL	1.6911 mL
	50 mM	0.0541 mL	0.2706 mL	0.5412 mL	1.3529 mL
	60 mM	0.0451 mL	0.2255 mL	0.4510 mL	1.1274 mL
	80 mM	0.0338 mL	0.1691 mL	0.3382 mL	0.8456 mL
	100 mM	0.0271 mL	0.1353 mL	0.2706 mL	0.6764 mL

N-Palmitoyl-l-leucine Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Palmitoyl-l-leucine14379-42-1GK144GK 144GK-144Phospholipasesecreted phospholipases A2Inhibitorinhibitorinhibit

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N-Palmitoyl-l-leucine (Synonyms: GK144)

N-Palmitoyl-l-leucine Related Antibodies

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