GSK2647544
Based on 1 Customer Validation
GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 1380426-95-8
- Formula: C24H18ClF3N4O3
- Molecular Weight:502.87
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolic Enzyme Compound Library
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Highly Selective Inhibitors Library
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Macrophage Related Compound Library
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All Phospholipase Isoforms
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1380426-95-8
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Appearance Solid
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Molecular Weight 502.87
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Formula C24H18ClF3N4O3
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Color White to off-white
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SMILES
O=C1NC(OCCC2=CC=C(C=C2)OC3=CC=C(C(C(F)(F)F)=C3)Cl)=NC=C1CC4=CN=CN=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (198.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9886 mL | 9.9429 mL | 19.8859 mL | 49.7146 mL |
| 5 mM | 0.3977 mL | 1.9886 mL | 3.9772 mL | 9.9429 mL | |
| 10 mM | 0.1989 mL | 0.9943 mL | 1.9886 mL | 4.9715 mL | |
| 15 mM | 0.1326 mL | 0.6629 mL | 1.3257 mL | 3.3143 mL | |
| 20 mM | 0.0994 mL | 0.4971 mL | 0.9943 mL | 2.4857 mL | |
| 25 mM | 0.0795 mL | 0.3977 mL | 0.7954 mL | 1.9886 mL | |
| 30 mM | 0.0663 mL | 0.3314 mL | 0.6629 mL | 1.6572 mL | |
| 40 mM | 0.0497 mL | 0.2486 mL | 0.4971 mL | 1.2429 mL | |
| 50 mM | 0.0398 mL | 0.1989 mL | 0.3977 mL | 0.9943 mL | |
| 60 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8286 mL | |
| 80 mM | 0.0249 mL | 0.1243 mL | 0.2486 mL | 0.6214 mL | |
| 100 mM | 0.0199 mL | 0.0994 mL | 0.1989 mL | 0.4971 mL |
GSK2647544 Related Classifications
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