9-Oxononanoic acid (Synonyms: 9-ONA)

Name: 9-Oxononanoic acid
Brand: MedChemExpress
SKU: HY-W612338
Rating: 4.5 (1 reviews)

Cat. No.: HY-W612338 Purity: 98.29%: Data Sheet
COA

SDS
Handling Instructions
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9-Oxononanoic acid (9-ONA) is an orally active acetyl-CoA carboxylase inhibitor. 9-Oxononanoic acid inhibits acetyl-CoA carboxylase via accumulation of long-chain acyl-CoA. 9-Oxononanoic acid increases carnitine palmitoyltransferase, isocitrate dehydrogenase and glucose 6-phosphate dehydrogenase activity to elevate β-oxidation and support NADPH (HY-113324) supplyactivity. 9-Oxononanoic acid stimulates phospholipase A2 activity via post-translational, non-transcriptional mechanisms. 9-Oxononanoic acid can be used for the research of atherothrombosis.

For research use only. We do not sell to patients.

9-Oxononanoic acid Chemical Structure

CAS No. : 2553-17-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

In Vitro

9-Oxononanoic acid (9-ONA) (1-9 μM; 10 min) treatment of fresh human whole blood increases PLA2 activity and TxB₂ levels in a dose-dependent manner, with 3 μM increasing PLA2 activity by ~10% and TxB₂ levels by ~50^[2].
9-Oxononanoic acid (3-9 μM; 10 min) incubation of fresh human whole blood under nitrogen at 37°C restores and increases both PLA2 activity and TxB₂ levels significantly, while incubation under nitrogen alone suppresses PLA2 activity and TxB₂ production^[2].
9-Oxononanoic acid (1-3 μM; 15 min) treatment of human platelet-rich plasma induces dose-dependent platelet aggregation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

9-Oxononanoic acid (9-ONA) (100 mg; i.g.; single dose) decreases hepatic lipogenesis by 70-80% via inhibition of acetyl-CoA carboxylase due to accumulated long-chain acyl-CoA, while increasing carnitine palmitoyltransferase activity by 35% and serum triacylglycerol levels decrease by 30% 30 hours post-dose in male Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar (male, 6 weeks old, ~100 g)^[1]
Dosage:	100 mg
Administration:	i.g.; single dose
Result:	Reduced de novo hepatic fatty acid synthesis by 80% when using [³H]acetate as a substrate. Reduced de novo hepatic fatty acid synthesis by 70% when using [¹⁴C]glucose as a substrate. Decreased hepatic acetyl-CoA carboxylase activity by 60%. Increased hepatic carnitine palmitoyltransferase activity by 35%. Lowered serum triacylglycerol levels by 30%. Increased hepatic NADPH/NADP ratio from 2.19 to 5.67. Increased hepatic glucose 6-phosphate dehydrogenase activity by 15%. Increased hepatic isocitrate dehydrogenase activity by 15%. Increased hepatic long-chain acyl-CoA levels from 39.0 to 81.3 nmol/g liver. Increased hepatic acetyl-CoA levels from 45.4 to 59.6 nmol/g liver. Increased hepatic CoASH levels from 80.0 to 190.6 nmol/g liver. Increased hepatic long-chain acyl-CoA/acetyl-CoA ratio from 0.859 to 1.36. Caused no changes in body weight gain, relative liver weight, serum free fatty acid levels, hepatic NADH/NAD ratio, hepatic phosphogluconate dehydrogenase activity, hepatic malate dehydrogenase activity, or hepatic fatty acid composition (except a minor reduction in phospholipid linoleic acid percentage).

Molecular Weight

172.22

Formula

C₉H₁₆O₃

CAS No.

2553-17-5

Appearance

Solid

Color

White to off-white

SMILES

O=CCCCCCCCC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (580.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8065 mL	29.0326 mL	58.0653 mL
5 mM	1.1613 mL	5.8065 mL	11.6131 mL
10 mM	0.5807 mL	2.9033 mL	5.8065 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (29.03 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (29.03 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (29.03 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.29%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (240 KB)

Handling Instructions (2659 KB)

References

[1]. Minamoto S, et al. Effect of orally administered 9-oxononanoic acid on lipogenesis in rat liver. Biochim Biophys Acta. 1988;958(2):199-204.

[2]. Ren R, et al. A lipid peroxidation product 9-oxononanoic acid induces phospholipase A2 activity and thromboxane A2 production in human blood. J Clin Biochem Nutr. 2013 May;52(3):228-33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.8065 mL	29.0326 mL	58.0653 mL	145.1632 mL
	5 mM	1.1613 mL	5.8065 mL	11.6131 mL	29.0326 mL
	10 mM	0.5807 mL	2.9033 mL	5.8065 mL	14.5163 mL
	15 mM	0.3871 mL	1.9355 mL	3.8710 mL	9.6775 mL
	20 mM	0.2903 mL	1.4516 mL	2.9033 mL	7.2582 mL
	25 mM	0.2323 mL	1.1613 mL	2.3226 mL	5.8065 mL
	30 mM	0.1936 mL	0.9678 mL	1.9355 mL	4.8388 mL
	40 mM	0.1452 mL	0.7258 mL	1.4516 mL	3.6291 mL
	50 mM	0.1161 mL	0.5807 mL	1.1613 mL	2.9033 mL
	60 mM	0.0968 mL	0.4839 mL	0.9678 mL	2.4194 mL
	80 mM	0.0726 mL	0.3629 mL	0.7258 mL	1.8145 mL
	100 mM	0.0581 mL	0.2903 mL	0.5807 mL	1.4516 mL

9-Oxononanoic acid Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-Oxononanoic acid2553-17-59-ONAAcetyl-CoA CarboxylaseACC, Acetyl Coenzyme A Carboxylasephospholipase A2rat liverlinoleic acidcarnitine palmitoyltransferaseβ-oxidationisocitrate dehydrogenaseglucose 6-phosphate dehydrogenaselong-chain acyl-CoAacetyl-CoA carboxylasehuman plateletsInhibitorinhibitorinhibit

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9-Oxononanoic acid (Synonyms: 9-ONA)

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Complete Stock Solution Preparation Table

9-Oxononanoic acid Related Classifications

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