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Results for "

collagenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (1) AMPK (1) Angiotensin Receptor (3) Antibiotic (1) Apoptosis (1) Autophagy (6) Bacterial (8) Biochemical Assay Reagents (13) COX (1) Drug Isomer (1) Elastase (3) Endogenous Metabolite (1) ERK (1) Fungal (2) Glycosidase (1) Interleukin Related (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) Lipoxygenase (1) MicroRNA (1) MMP (29) mTOR (1) NF-κB (2) NO Synthase (1) p38 MAPK (3) Parasite (1) Phosphodiesterase (PDE) (2) Proteasome (7) Reactive Oxygen Species (ROS) (2) Reference Standards (7) Ser/Thr Protease (3) SOD (2) TGF-beta/Smad (5) TGF-β Receptor (3) TNF Receptor (5) Tyrosinase (8) Xanthine Oxidase (2)
By Research Areas:	Cancer (23) Cardiovascular Disease (4) Endocrinology (1) Infection (12) Inflammation/Immunology (20) Metabolic Disease (6) Neurological Disease (8)

By Targets:

Aminopeptidase (1)

AMPK (1)

Angiotensin Receptor (3)

Antibiotic (1)

Apoptosis (1)

Autophagy (6)

Bacterial (8)

Biochemical Assay Reagents (13)

COX (1)

Drug Isomer (1)

Elastase (3)

Endogenous Metabolite (1)

ERK (1)

Fungal (2)

Glycosidase (1)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

Lipoxygenase (1)

MicroRNA (1)

MMP (29)

mTOR (1)

NF-κB (2)

NO Synthase (1)

p38 MAPK (3)

Parasite (1)

Phosphodiesterase (PDE) (2)

Proteasome (7)

Reactive Oxygen Species (ROS) (2)

Reference Standards (7)

Ser/Thr Protease (3)

SOD (2)

TGF-beta/Smad (5)

TGF-β Receptor (3)

TNF Receptor (5)

Tyrosinase (8)

Xanthine Oxidase (2)

By Research Areas:

Cancer (23)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (12)

Inflammation/Immunology (20)

Metabolic Disease (6)

Neurological Disease (8)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70005D

Collagenase IV, Clostridium histolytica 10+ Cited Publications collagenase, Type IV	MMP	Others
Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.

HY-E70005B

Collagenase, Type II 10+ Cited Publications	MMP	Others
Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-15768

Ilomastat Maximum Cited Publications 61 Publications Verification GM6001; Galardin	MMP	Cancer
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-E70005A

Collagenase, Type I 15+ Cited Publications EC 3.4.24.3	MMP	Others
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

HY-131577

Neutral protease, Paenibacillus polymyxa 5 Publications Verification Dispase II, Dispase	Endogenous Metabolite	Metabolic Disease
Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .

HY-O0004

Collagenase I, from Clostridium histolyticum 1 Publications Verification	MMP	Metabolic Disease
Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation.

HY-E70005H

Collagenase, Type VIII	Proteasome	Cardiovascular Disease
Collagenase, Type VIII is a mixed enzyme derived from Clostridium histolyticum that contains collagenase, a nonspecific protease, and a clostripain. Collagenase, Type VIII can hydrolyze Type VIII collagen and may be used to study the formation of atherosclerosis. Type VIII collagen is a regulator of endothelial cell differentiation and angiogenesis, a substrate for cell adhesion and migration such as smooth muscle cells, and may accumulate in atherosclerosis. After endotoxin activates the expression of Collagenase, Type VIII, it can reduce the production of Type VIII collagen and has the potential to inhibit atherosclerosis .

HY-N0136

Taxifolin Maximum Cited Publications 27 Publications Verification (+)-Dihydroquercetin; (+)-Taxifolin	TNF Receptor Autophagy Tyrosinase	Inflammation/Immunology Cancer
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against *collagenase* with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-E70005N

Collagenase (Type D, animal free) 2 Publications Verification	Biochemical Assay Reagents	Others
Collagenase (Type D, animal free) does not contain animal-related components, and has collagenase and secondary protease activities similar to type 1 and type 2 collagenase. The activity of Collagenase (Type D, animal free) is higher than that of Collagenase (Type A, animal free).

HY-E70005I

Collagenase, Type VI 1 Publications Verification Type VI collagenase	MMP	Cancer
Collagenase, Type VI (EC 3.4.24.3) is a collagenase that can degrade type VI collagen. Type VI collagen is a component of cell membranes in various tissues (such as skin, heart, blood vessels, cartilage, and synovial fluid). Excessive collagenase can cause extracellular matrix lesions. Collagenase is also a biomarker for tumor invasion and metastasis. Collagenase, Type VI can specifically act on the peptide bond between proline and glycine. This feature can be used to quickly and sensitively detect its concentration level in experiments using corresponding modified electrodes .

HY-E70005C

Collagenase, Type III	MMP	Others
Collagenase, Type III is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin

HY-100113

Buloxibutid 5 Publications Verification AT2 receptor agonist C21	Angiotensin Receptor p38 MAPK TGF-beta/Smad TGF-β Receptor MMP	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a K_i value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis .

HY-E70005E

Collagenase, Type V 1 Publications Verification	MMP	Others
Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-P4931

Mca-KPLGL-Dap(Dnp)-AR-NH2 1 Publications Verification	MMP	Cancer
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)

HY-E70005J

Collagenase, Type VII Type VII collagenase	MMP	Neurological Disease
Collagenase, Type VII (EC 3.4.24.3) is a collagenase that can be used to induce thalamic hemorrhage .

HY-P2661

FA-Leu-Gly-Pro-Ala-OH	Biochemical Assay Reagents Bacterial	Infection
FA-Leu-Gly-Pro-Ala-OH is a furylacryloyl-terminal tetrapeptide that serves as a substrate for bacterial collagenase and spirochete metalloendopeptidase. FA-Leu-Gly-Pro-Ala-OH is specifically hydrolyzed by spirochete collagenase only at the Leu-Gly bond. FA-Leu-Gly-Pro-Ala-OH can be used to determine the equilibrium constant of peptide bond hydrolysis, and also to detect collagenase-mediated cleavage reactions via turbidimetry based on absorbance reduction .

HY-E70005K

Collagenase (Type A, animal free)	Proteasome	Others
Collagenase (Type A, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-N6013

Aloin (mixture of A&B)	MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum *collagenase, granulocyte matrix metalloproteinases* and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-N1881

4',5-Dihydroxyflavone 3 Publications Verification	Lipoxygenase Glycosidase	Inflammation/Immunology
4',5-Dihydroxyflavone (Compound 2c; Compound B3) is a type of flavonoid compound. 4',5-Dihydroxyflavone can inhibit various oxidases and its IC₅₀ values for collagenase A (ColA) and α-glucosidase are less than 1 μM and 66 μM respectively; for soybean lipoxygenase-1 (LOX-1), its K_i value is 102.6 μM. 4',5-Dihydroxyflavone can be used in studies on anti-toxicity and anti-diabetes .

HY-N0616

Trifolirhizin	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB	Infection Metabolic Disease Inflammation/Immunology Cancer
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-E70005M

Collagenase (Type C, animal free)	Proteasome	Others
Collagenase (Type C, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-16182

Ecamsule 1 Publications Verification	Biochemical Assay Reagents	Others
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

HY-15652

Freselestat ONO-6818; ONO-PO-736	Elastase	Inflammation/Immunology
Freselestat (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat has a potent anti-inflammatory activity .

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Phosphodiesterase (PDE)	Neurological Disease Cancer
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-E70005L

Collagenase (Type B, animal free)	Proteasome	Others
Collagenase (Type B, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-116399

MMP-2/MMP-9-IN-1	MMP	Cancer
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC₅₀s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer .

HY-16182A

Ecamsule disodium 1 Publications Verification	Biochemical Assay Reagents	Others
Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .

HY-N2472

Medicagenic acid Castanogenin	Bacterial Xanthine Oxidase	Infection
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-122624

MMP13-IN-2	MMP	Inflammation/Immunology
MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC₅₀=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research .

HY-19677

Cipemastat Ro 32-3555	MMP	Cancer
Cipemastat is a potent, competitive inhibitor of human *collagenases* 1, 2 and 3 with K_is of 3.0, 4.4 and 3.4 nM, respectively.

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-122106

RS-104966	MMP	Others
RS-104966 is a potent collagenase-1 (MMP-1) inhibitor. RS-104966 induces a conformational change in the side chains of the S10 pocket of MMP-1 .

HY-N0136R

Taxifolin (Standard) (+)-Dihydroquercetin (Standard); (+)-Taxifolin (Standard)	TNF Receptor Reference Standards Autophagy Tyrosinase	Inflammation/Immunology
Taxifolin (Standard) is the analytical standard of Taxifolin. This product is intended for research and analytical applications. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-E70005P

Collagenase (Type B, filtered, animal free)	Biochemical Assay Reagents	Others
Collagenase (Type B, animal free) does not contain animal-related components, and is sterilized by filtration using a 0.22 μm filter membrane. Collagenase (Type B, filtered, animal free) has higher collagenase and casein activity.

HY-100210A

FN-439 TFA	MMP	Inflammation/Immunology Cancer
FN-439 TFA is a selective *collagenase-1* inhibitor. FN-439 TFA inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation .

HY-E70005O

Collagenase (Type A, filtered, animal free)	Proteasome	Others
Collagenase (Type A, filtered, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-N1235

Skullcapflavone I Panicolin	Elastase MicroRNA	Cancer
Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits *collagenase* and elastase enzyme with IC₅₀s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a .

HY-P4363

Suc-GPLGP-AMC	Biochemical Assay Reagents	Others
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .

HY-N0136B

(-)-Taxifolin (-)-Dihydroquercetin	Tyrosinase	Inflammation/Immunology
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against *collagenase* with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N0136A

(±)-Taxifolin (±)-Dihydroquercetin	Drug Isomer TNF Receptor Autophagy Tyrosinase	Inflammation/Immunology Cancer
(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin (HY-N0136). Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against *collagenase* with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone	NF-κB COX TNF Receptor NO Synthase Reactive Oxygen Species (ROS) Parasite	Infection Metabolic Disease Inflammation/Immunology Cancer
2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity .

HY-E70005Q

Collagenase (Type C, filtered, animal free)	Biochemical Assay Reagents	Others
Collagenase (Type C, filtered, animal free) does not contain animal-related components, and is sterilized by filtration using a 0.22 μm filter membrane. Collagenase (Type C, filtered, animal free) has low trypsin activity similar to type 4 collagenase.

HY-E70531

Collagenase/Neutral protease 2 (animal free)	Biochemical Assay Reagents	Others
Collagenase/Neutral protease 2 (animal free) is an animal-free mixture of collagenase and neutral protease that can be used for stem cell and other primary cell isolation and bioprocessing applications without the introduction of potential animal-borne pathogens. It has higher casein activity than Collagenase/Neutral Protease 1 (animal free).

HY-137521

Z-PDLDA-NHOH	MMP	Others
Z-PDLDA-NHOH is a potent and specific inhibitor of vertebrate collagenase .

HY-E70368

Collagenase G (Recombinant)	Biochemical Assay Reagents	Others
Collagenase G Recombinant is involved in the islet isolation process, and digests specific collagens from the N-terminus, especially Col-V .

HY-P2641

Peptide 74	MMP	Cancer
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .

HY-N0136S

Taxifolin-d3 (+)-Dihydroquercetin-d₃; (+)-Taxifolin-d₃	Isotope-Labeled Compounds Autophagy Tyrosinase	Inflammation/Immunology
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N2472R

Medicagenic acid (Standard) Castanogenin (Standard)	Xanthine Oxidase Reference Standards Bacterial	Infection
Medicagenic acid (Standard) is the analytical standard of Medicagenic acid. This product is intended for research and analytical applications. Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-16182R

Ecamsule (Standard)	Biochemical Assay Reagents Reference Standards	Others
Ecamsule (Standard) is the analytical standard of Ecamsule. This product is intended for research and analytical applications. Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

HY-15652A

Freselestat quarterhydrate ONO-6818 quarterhydrate; ONO-PO-736 quarterhydrate	Elastase	Inflammation/Immunology
Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity .

Cat. No.	Product Name	Type

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone

Biochemical Assay Reagents

2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity .

Cat. No.	Product Name	Target	Research Area

HY-P4931

Mca-KPLGL-Dap(Dnp)-AR-NH2 1 Publications Verification	MMP	Cancer
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)

HY-P2661

FA-Leu-Gly-Pro-Ala-OH	Biochemical Assay Reagents Bacterial	Infection
FA-Leu-Gly-Pro-Ala-OH is a furylacryloyl-terminal tetrapeptide that serves as a substrate for bacterial collagenase and spirochete metalloendopeptidase. FA-Leu-Gly-Pro-Ala-OH is specifically hydrolyzed by spirochete collagenase only at the Leu-Gly bond. FA-Leu-Gly-Pro-Ala-OH can be used to determine the equilibrium constant of peptide bond hydrolysis, and also to detect collagenase-mediated cleavage reactions via turbidimetry based on absorbance reduction .

HY-P4474

Pz-Pro-Leu-Gly-Pro-d-Arg	Peptides	Others
Pz-Pro-Leu-Gly-Pro-d-Arg is a synthetic polypeptide substrate. Pz-Pro-Leu-Gly-Pro-d-Arg can be used to detect the collagenase-like activity of enzymes from various sources, such as Bacillus sp. AH-101 .

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-P4363

Suc-GPLGP-AMC	Biochemical Assay Reagents	Others
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .

HY-P4474A

Pz-Pro-Leu-Gly-Pro-d-Arg TFA	Peptides	Others
Pz-Pro-Leu-Gly-Pro-d-Arg TFA is a synthetic polypeptide substrate. Pz-Pro-Leu-Gly-Pro-d-Arg TFA can be used to detect the collagenase-like activity of enzymes from various sources, such as Bacillus sp. AH-101 .

HY-137521

Z-PDLDA-NHOH	MMP	Others
Z-PDLDA-NHOH is a potent and specific inhibitor of vertebrate collagenase .

HY-P2641

Peptide 74	MMP	Cancer
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .

HY-100210

FN-439	MMP	Inflammation/Immunology Cancer
FN-439 is a selective *collagenase-1* inhibitor. FN-439 inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 can be used for the research of cancer and inflammation .

HY-P2718

Z-Gly-Pro-Gly-Gly-Pro-Ala-OH	Biochemical Assay Reagents	Others
Z-Gly-Pro-Gly-Gly-Pro-Ala-OH is a collagenase substrate that induces planulae to settle .

HY-P10139

Dnp-PLGLWAr-NH2	MMP	Others
Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples .

HY-P2661A

FA-Leu-Gly-Pro-Ala-OH TFA	Biochemical Assay Reagents Bacterial	Infection
FA-Leu-Gly-Pro-Ala-OH TFA is a furylacryloyl-terminal tetrapeptide that serves as a substrate for bacterial collagenase and spirochete metalloendopeptidase. FA-Leu-Gly-Pro-Ala-OH TFA is specifically hydrolyzed by spirochete collagenase only at the Leu-Gly bond. FA-Leu-Gly-Pro-Ala-OH TFA can be used to determine the equilibrium constant of peptide bond hydrolysis, and also to detect collagenase-mediated cleavage reactions via turbidimetry based on absorbance reduction .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-131577

Neutral protease, Paenibacillus polymyxa 5 Publications Verification Dispase II, Dispase	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .

HY-N0136

Taxifolin Maximum Cited Publications 27 Publications Verification (+)-Dihydroquercetin; (+)-Taxifolin	Flavanonols Structural Classification Flavonoids other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor Autophagy Tyrosinase
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against *collagenase* with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N6013

Aloin (mixture of A&B)	Infection Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields Source Classification	MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal
Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum *collagenase, granulocyte matrix metalloproteinases* and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-N1881

4',5-Dihydroxyflavone 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Glycine max (L.) merr Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Lipoxygenase Glycosidase
4',5-Dihydroxyflavone (Compound 2c; Compound B3) is a type of flavonoid compound. 4',5-Dihydroxyflavone can inhibit various oxidases and its IC₅₀ values for collagenase A (ColA) and α-glucosidase are less than 1 μM and 66 μM respectively; for soybean lipoxygenase-1 (LOX-1), its K_i value is 102.6 μM. 4',5-Dihydroxyflavone can be used in studies on anti-toxicity and anti-diabetes .

HY-N0616

Trifolirhizin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Trifolium pratense Linn. Sophora flavescens Aiton Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-N2472

Medicagenic acid Castanogenin	Infection Triterpenes Classification of Application Fields Herniaria glabra Linnaeus. Terpenoids Plants Disease Research Fields Caryophyllaceae	Bacterial Xanthine Oxidase
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-N0136R

Taxifolin (Standard) (+)-Dihydroquercetin (Standard); (+)-Taxifolin (Standard)	Flavanonols Structural Classification Flavonoids other families Phenols Polyphenols Plants Source Classification	TNF Receptor Reference Standards Autophagy Tyrosinase
Taxifolin (Standard) is the analytical standard of Taxifolin. This product is intended for research and analytical applications. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N1235

Skullcapflavone I Panicolin	Flavonols Flavonoids Labiatae Plants Medicago truncatula Gaertn. Source Classification	Elastase MicroRNA
Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits *collagenase* and elastase enzyme with IC₅₀s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a .

HY-N0136B

(-)-Taxifolin (-)-Dihydroquercetin	Flavanonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Source Classification	Tyrosinase
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against *collagenase* with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N0136A

(±)-Taxifolin (±)-Dihydroquercetin	Flavanonols Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Drug Isomer TNF Receptor Autophagy Tyrosinase
(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin (HY-N0136). Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against *collagenase* with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N2472R

Medicagenic acid (Standard) Castanogenin (Standard)	Triterpenes Structural Classification Herniaria glabra Linnaeus. Terpenoids Plants Caryophyllaceae	Xanthine Oxidase Reference Standards Bacterial
Medicagenic acid (Standard) is the analytical standard of Medicagenic acid. This product is intended for research and analytical applications. Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-N6013R

Aloin (mixture of A&B) (Standard)	Structural Classification Liliaceae Ketones, Aldehydes, Acids Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Source Classification	Reference Standards Proteasome MMP Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Fungal Bacterial
Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum *collagenase, granulocyte matrix metalloproteinases* and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-N3654

Cyclo(l-Pro-d-Leu)	Microorganisms Antibiotics Source Classification	Tyrosinase
Cyclo(l-Pro-d-Leu) (compound 11) is a *collagenase* inhibitor that can be extracted from R. atalantica and also exhibits a mild tyrosinase inhibitory effect .

HY-125422

Matlystatin A	Natural Products Microorganisms Source Classification	Aminopeptidase
Matlystatin A is a potent aminopeptidase inhibitor, with IC₅₀ values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. Matlystatin A can be utilized in cancer research .

HY-N14759

Matlystatin B	Natural Products Microorganisms Source Classification	Bacterial
Matlystatin B is a type IV collagenase inhibitor. Matlystatin B has anti-Gram-positive bacteria effect .

HY-N14772

Laccaridione A	Quinones Microorganisms Naphthalene Quinones Source Classification	Ser/Thr Protease
Laccaridione A can inhibit the activity of antiserine protease. Laccaridione A inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC₅₀s of 14.7 μg/mL, 2.5 μg/mL, 18.8 μg/mL, 7.2 μg/mL and 18.2 μg/mL, respectively .

HY-N12742

Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside	Flavonoids Flavones Astragalus thracicus Griseb. Phenols Plants Fabaceae Source Classification	Others
Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (compound 4) is an inhibitor of collagenase and elastase with potential anti-inflammatory activity. Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside can be isolated from the methanol extract of the Balkan endemic species Astragalus thracicus Griseb .

HY-N2038R

3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone (Standard)	Structural Classification Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Reference Standards Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone (Standard) is the analytical standard of 3,5,6,7,8,3',4'-Heptemthoxyflavone (HY-N2038). This product is intended for research and analytical applications. 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-N13896

Aureoquinone	Quinones Microorganisms Naphthalene Quinones Source Classification	Ser/Thr Protease
Aureoquinone is a broad-spectrum protease inhibitor. Aureoquinone inhibits trypsin, papain, thermophilic protease, collagenase and pound-protease, with IC₅₀ values of 11.4 μg/mL, 14.5 μg/mL, 17.8 μg/mL, 7.1 μg/mL, and 8.7 μg/mL, respectively .

HY-N14773

Laccaridione B	Quinones Microorganisms Naphthalene Quinones Source Classification	Ser/Thr Protease
Laccaridione B can inhibit the activity of antiserine protease. Laccaridione B inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC₅₀s of 10.9 μg/mL, 5.1 μg/mL, 8.4 μg/mL, 5.7 μg/mL and 3.0 μg/mL, respectively. Laccaridione B also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC₅₀s of 2.4 μg/mL, 1.8 μg/mL and 13.9 μg/mL, respectively .

Species:	Human (13) Rat (1) Mouse (11) Cynomolgus (1)
Tag:	His (20) Tag Free (5) Fc (1)
Source:	HEK293 (21) CHO (1) P. pastoris (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70250

	MMP-1 Protein, Human (HEK293, His, solution) 1 Publications Verification rHuInterstitial collagenase/MMP-1, His; Interstitial collagenase; Fibroblast collagenase; Matrix Metalloproteinase-1; MMP-1; MMP1; CLG	Human	HEK293
	The MMP-1 protein acts as an enzyme capable of cleaving types I, II, and III collagen at specific sites within the helical domain. In addition, it exhibits lytic activity against type VII and type X collagen. MMP-1 Protein, Human (HEK293, His, solution) is the recombinant human-derived MMP-1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70250A

	MMP-1 Protein, Human (HEK293, C-His) rHuInterstitial collagenase/MMP-1, His; Interstitial collagenase; Fibroblast collagenase; Matrix Metalloproteinase-1; MMP-1; MMP1; CLG	Human	HEK293
	The MMP-1 protein acts as an enzyme capable of cleaving types I, II, and III collagen at specific sites within the helical domain. In addition, it exhibits lytic activity against type VII and type X collagen. MMP-1 Protein, Human (HEK293, C-His) is the recombinant human-derived MMP-1, expressed by HEK293, with C-6*His labeled tag.

HY-P701987

	MMP-13 Protein, Human (His) MMP13; collagenase 3; Matrix metalloproteinase-13; MMP-13	Human	E. coli
	The MMP-13 protein plays a role in the degradation of extracellular matrix proteins, especially fibrillar collagen, fibronectin, TNC, and ACAN. It cleaves triple-helical collagen, preferentially cleaves type II collagen, and can also target other collagen types. MMP-13 Protein, Human (His) is the recombinant human-derived MMP-13 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700793

	MMP-8 Protein, Cynomolgus (HEK293, His) PMNL-CL; CLG1; MMP8; collagenase 2; PMNL-CL; HNC	Cynomolgus	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MMP-8 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72507

	MMP-8 Protein, Human (HEK293, His) 1 Publications Verification Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; MMP8; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293, His) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78328

	MMP-8 Protein, Mouse (HEK293, His) MMP-8; PMNL-CL; CLG1; MMP8; collagenase 2; PMNL-CL; HNC	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III.It is implicated in the breakdown of collagen fibers during uterine involution.MMP-8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71110

	TIMP-1 Protein, Mouse (HEK293) 1 Publications Verification Metalloproteinase Inhibitor 1; Erythroid-Potentiating Activity; EPA; Fibroblast collagenase Inhibitor; collagenase Inhibitor; Tissue Inhibitor of Metalloproteinases 1; TIMP-1; TIMP1; CLGI; TIMP	Mouse	HEK293
	TIMP-1 is a metalloproteinase inhibitor that irreversibly inactivates collagenase and other metalloproteinases by binding to their catalytic zinc cofactor.It regulates MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16 and affects cellular processes such as differentiation, migration and cell death.TIMP-1 Protein, Mouse (HEK293) is the recombinant mouse-derived TIMP-1 protein, expressed by HEK293 , with tag free.

HY-P73298

	MMP-8 Protein, Human (HEK293) Neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with N-Met labeled tag.

HY-P73808

	MMP-8 Protein, Mouse (HEK293) Neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III.It is implicated in the breakdown of collagen fibers during uterine involution.MMP-8 Protein, Mouse (HEK293) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293 , with tag free.

HY-P73809

	MMP-8 Protein, Mouse (CHO, His) Neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Mouse	CHO
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III.It is implicated in the breakdown of collagen fibers during uterine involution.MMP-8 Protein, Mouse (CHO, His) is the recombinant mouse-derived MMP-8 protein, expressed by CHO , with C-His labeled tag.

HY-P702527

	MMP-13 Protein, Human (HEK293) CLG 3; CLG3EC 3.4.24; collagenase 3; EC 3.4.24.-; EC 3.4.24.22; EC 3.4.24.24; EC 3.4.24.35; EC 3.4.24.65; EC 3.4.24.7; MANDP1; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); Matrix metalloproteinase-13; MMP13; MMP-13	Human	HEK293
	The MMP-13 protein plays a role in the degradation of extracellular matrix proteins, especially fibrillar collagen, fibronectin, TNC, and ACAN. It cleaves triple-helical collagen, preferentially cleaves type II collagen, and can also target other collagen types. MMP-13 Protein, Human (HEK293) is the recombinant human-derived MMP-13 protein, expressed by HEK293 , with tag free.

HY-P71055

	TIMP-1 Protein, Human (HEK293, His) Metalloproteinase Inhibitor 1; Erythroid-Potentiating Activity; EPA; Fibroblast collagenase Inhibitor; collagenase Inhibitor; Tissue Inhibitor of Metalloproteinases 1; TIMP-1; TIMP1; CLGI; TIMP	Human	HEK293
	The TIMP-1 protein forms a one-to-one complex with the target metalloprotease, irreversibly inactivating it by binding to the catalytic zinc cofactor. It inhibits multiple MMPs, activates cell signaling through CD63 and ITGB1, and interacts with MMP1, MMP3, MMP10, and MMP13. TIMP-1 Protein, Human (HEK293, His) is the recombinant human-derived TIMP-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704924

	TIMP-1 Protein, Mouse (HEK293, His) Metalloproteinase Inhibitor 1; Erythroid-Potentiating Activity; EPA; Fibroblast collagenase Inhibitor; collagenase Inhibitor; Tissue Inhibitor of Metalloproteinases 1; TIMP-1; TIMP1; CLGI; TIMP	Mouse	HEK293

HY-P70268

	MMP-2 Protein, Human (HEK293, His) 3 Publications Verification rHu72 kDa type IV collagenase/MMP-2, His ; 72 kDa Type IV collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; MMP-2; TBE-1; MMP2; CLG4A	Human	HEK293
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Human (HEK293, His) is the recombinant human-derived MMP-2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700573

	MMP-2 Protein, Rat (P. pastoris, His) 1 Publications Verification rHu72 kDa type IV collagenase/MMP-2, His ; 72 kDa Type IV collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; MMP-2; TBE-1; MMP2; CLG4A	Rat	P. pastoris
	MMP-2 is a multifunctional metalloproteinase that plays multiple roles in vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, MMP-2 also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Rat (P. pastoris, His) is the recombinant rat-derived MMP-2 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P700139AF

	Animal-Free MMP-2 Protein, Human (His) rHu72 kDa type IV collagenase/MMP-2, His ; 72 kDa Type IV collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; MMP-2; TBE-1; MMP2; CLG4A	Human	E. coli
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. Animal-Free MMP-2 Protein, Human (His) is the recombinant human-derived animal-FreeMMP-2 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P704792

	MMP-8 Protein, Mouse (242a.a, HEK293, His) Neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III. It is implicated in the breakdown of collagen fibers during uterine involution. MMP-8 Protein, Mouse (242a.a, HEK293, His) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293, with C-His labeled tag.

HY-P70029

	Basigin/CD147 Protein, Human (HEK293, His) rHuBasigin/CD147, His ; Basigin; 5F7; collagenase Stimulatory Factor; Extracellular Matrix Metalloproteinase Inducer; EMMPRIN; Leukocyte Activation Antigen M6; OK Blood Group Antigen; Tumor Cell-Derived collagenase Stimulatory Factor; TCSF; CD147; BSG	Human	HEK293
	Basigin/BSG proteins are critical for retinal maturation and development and function as retinal cell receptors for NXNL1, promoting the survival of retinal cone photoreceptors. Basigin/CD147 Protein, Human (HEK293, His) is the recombinant human-derived Basigin/CD147 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73296

	MMP-2 Protein, Human (HEK293) Maximum Cited Publications 8 Publications Verification 72 kDa Type IV collagenase; Gelatinase A; MMP-2; TBE-1; CLG4A	Human	HEK293
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Human (HEK293) is the recombinant human-derived MMP-2 protein, expressed by HEK293 , with tag free.

HY-P73810

	MMP-2 Protein, Mouse (HEK293, His) 72 kDa Type IV collagenase; Gelatinase A; MMP-2; TBE-1; CLG4A	Mouse	HEK293
	MMP-2 protein is a ubiquitous metalloprotease that contributes to vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to extracellular matrix degradation, it also targets non-matrix proteins and promotes vasoconstriction. MMP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P705699

	MMP-2 Protein, Mouse (HEK293, Fc) 72 kDa Type IV collagenase; Gelatinase A; MMP-2; TBE-1; CLG4A	Mouse	HEK293
	MMP-2 protein is a ubiquitous metalloprotease that contributes to vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to extracellular matrix degradation, it also targets non-matrix proteins and promotes vasoconstriction. MMP-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived MMP-2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705697

	MMP-2 Protein, Mouse (431a.a, HEK293, His) 72 kDa Type IV collagenase; Gelatinase A; MMP-2; TBE-1; CLG4A	Mouse	HEK293
	MMP-2 protein is a ubiquitous metalloprotease that contributes to vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to extracellular matrix degradation, it also targets non-matrix proteins and promotes vasoconstriction. MMP-2 Protein, Mouse (431a.a, HEK293, His) is the recombinant mouse-derived MMP-2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700572

	MMP-9 Protein, Human (P. pastoris, His) rHuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; MMP9	Human	P. pastoris
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (P. pastoris, His) is the recombinant human-derived MMP-9 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70145A

	MMP-9 Protein, Human (HEK293, C-His) rHuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; MMP9	Human	HEK293
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (HEK293, C-His) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70351A

	MMP-9 Protein, Mouse (HEK293, C-His) 1 Publications Verification rMuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration.It is suggested that it may be involved in bone osteoclastic resorption.MMP-9 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P70351

	MMP-9 Protein, Mouse (HEK293, His, solution) rMuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration.It is suggested that it may be involved in bone osteoclastic resorption.MMP-9 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-N0136S

Taxifolin-d3
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N0136S1

(±)-Taxifolin-13C3

(±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

Host:	Mouse (2) Rabbit (11)
Reactivity:	Human (13) Rat (4) Mouse (5)
Application:	IHC-P (9) ICC/IF (8) IF-Tissue (1) IP (3) IHC-F (3) WB (13) FC (3) ELISA (2)
Isotype:	IgG (9) IgG1 (1) IgG2a (1) IgG/Kappa (2)
Conjugation:	Non-conjugated (13)
Clonality:	Polyclonal (2) Monoclonal (10) Recombinant (4)
Modification:	Unmodified (12)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86656

	MMP-9 Antibody (YA6348) Matrix metalloproteinase-9 precursor; MMP-9; MMP9; MMP 9; 92 kDa type IV; collagenase; 92 kDa gelatinase; Gelatinase B; GELB; MMP9_HUMAN; 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG-4B; CLG4B; collagenase Type 4 beta; collagenase Type-4 beta; collagenase type IV 92 KD; collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase 92 KD; Gelatinase beta; Gelatinase-beta; GelatinaseB; GELB; Macrophage gelatinase; MANDP2; Matrix metallopeptidase 9(gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix Metalloproteinase 9; Type V collagenase.	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	MMP-9 Antibody (YA6348) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP-9.

HY-P80754

	MMP-1 Antibody MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1	WB, IP	Human
	MMP-1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MMP-1.

HY-P83398

	MMP13 Antibody (YA3143) MMP13; collagenase 3; Matrix metalloproteinase-13; MMP-13	WB	Human, Mouse
	MMP13 Antibody (YA3143) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP13.

HY-P86592

	MMP13 Antibody (YA6284) MMP13; collagenase 3; Matrix metalloproteinase-13; MMP-13	WB, IHC-P, ICC/IF, ELISA	Human
	MMP13 Antibody (YA6284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP13.

HY-P80754A

	MMP-1 Antibody (YA3394) MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1	WB, FC, ICC/IF, IHC-P	Human
	MMP-1 Antibody (YA3394) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP-1.

HY-P85280

	MMP-1 Antibody (YA4972) MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1	WB	Human
	MMP-1 Antibody (YA4972) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MMP-1.

HY-P81133

	TIMP-1 Antibody (YA3543) 1 Publications Verification Clgi; collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.	WB, IHC-P, ICC/IF	Human
	TIMP-1 Antibody (YA3543) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TIMP-1.

HY-P83285

	MMP8 Antibody (YA3030) HNC; CLG1; MMP-8; PMNL-CL; collagenase I; NEUTROPHIL; matrix metalloproteinase 8	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MMP8 Antibody (YA3030) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP8.

HY-P80756

	MMP-9 Antibody 2 Publications Verification MMP9; CLG4B; Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	MMP-9 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MMP-9.

HY-P86224

	MMP2 Antibody (YA5916) MMP2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MMP2 Antibody (YA5916) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP2.

HY-P83689

	CD147 Antibody (YA3422) HT-7; CD147; EMMPRIN; AI115436; AI325119; BSG; Basigin; 5F7; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD antigen CD147	WB, IHC-P, IHC-F, ICC/IF	Human
	CD147 Antibody (YA3422) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD147.

HY-P83689A

	CD147 Antibody (YA3422)(PBS only) HT-7; CD147; EMMPRIN; AI115436; AI325119; BSG; Basigin; 5F7; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD antigen CD147	WB, IHC-P, IHC-F, ICC/IF	Human
	CD147 Antibody (YA3422) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD147.

HY-P80356

	TIMP2 Antibody (YA034) 1 Publications Verification Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.	WB, IHC-P, FC	Human
	TIMP2 Antibody (YA034) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIMP2.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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