Collagenase (Type C, filtered, animal free)
Collagenase (Type C, filtered, animal free) is a microbial collagenolytic enzyme that can be found in Clostridium histolyticum, leeches, or Paralithodes camtschaticus (Kamchatka crab). The activity of Collagenase (Type C, filtered, animal free) is completely inhibited by tea catechins, especially (-)-epicatechin gallate (ECg) (HY-N0356) and (-)-epigallocatechin gallate (EGCg). Collagenase (Type C, filtered, animal free) is used in research related to Peyronie's disease.
For research use only. We do not sell to patients.
- CAS No.: 9001-12-1
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
In Vitro
Clostridium histolyticum-derived Collagenase (Type C, filtered, animal free) (10-50 ng/mL; 30-120 min) digests up to 85-90% of collagen at 50 ng/mL after 120 min incubation at 35°C in a fluorometric collagen digestion assay, with activity increasing with higher concentrations and longer incubation times[2].
Collagenase (Type C, filtered, animal free) (50 ng/mL; 120 min) displays collagenolytic activity at 50 ng/mL over 120 min at 35°C in a fluorometric collagen digestion assay, and this activity is fully inhibited by 100 μg/mL tea catechins[2].
Paralithodes camtschatica-derived Collagenase (Type C, filtered, animal free) (50 ng/mL; 120 min) displays collagenolytic activity at 50 ng/mL over 120 min at 35°C in a fluorometric collagen digestion assay, and this activity is fully inhibited by 100 μg/mL tea catechins[2].
Porphyromonas gingivalis 381-derived Collagenase (Type C, filtered, animal free) (Culture supernatant; 120 min) displays collagenolytic activity in culture supernatant over 120 min at 35°C in a fluorometric collagen digestion assay, and this activity is fully inhibited by 100 μg/mL tea catechins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 9001-12-1
-
SMILES
[Collagenase (Type C, filtered, animal free)]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)