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Cat. No.: HY-123886

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Aranciamycin

Aranciamycin (Compound 1) is an anthracycline antibiotic with collagenase inhibitory activity (IC₅₀3.7*10_-7M). Aranciamycin can be used to inhibit DNA synthesis in tumor cells .

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CAS No.: 72389-06-1
화학식: C₂₇H₂₈O₁₂
분자량:544.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Aranciamycin Chemical Structure

CAS No.: 72389-06-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Aranciamycin (Compound 1) is an anthracycline antibiotic with collagenase inhibitory activity (IC₅₀3.7*10_-7M). Aranciamycin can be used to inhibit DNA synthesis in tumor cells ^[1].

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.7 μM Compound: 7	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 38412432]
HeLa	IC₅₀	2.7 μM Compound: 3	Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay	[PMID: 20192240]
HepG2	IC₅₀	18 μM Compound: 4	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]
HL-60	IC₅₀	4.1 μM Compound: 3	Cytotoxicity against human HL60 cells after 48 hrs by WST8 assay Cytotoxicity against human HL60 cells after 48 hrs by WST8 assay	[PMID: 20192240]
KB 3-1	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human KB-3-1 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human KB-3-1 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]
NCI-H460	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]
PC-3	IC₅₀	1.1 μM Compound: 7	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 38412432]
SW-620	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human SW620 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human SW620 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]

Chemical Information

CAS No. 72389-06-1
분자량 544.50
화학식 C₂₇H₂₈O₁₂
SMILES

O=C1[C@@](C)(O)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)OC)C(C(O)=C3C(C4=C5C=CC=C4O)=O)=C1C=C3C5=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bols M, et al. Inhibition of collagenase by aranciamycin and aranciamycin derivatives. J Med Chem. 1992 Jul 24;35(15):2768-71. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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