2. Anti-infection
  3. Antibiotic
  4. Aranciamycin

Aranciamycin (Compound 1) is an anthracycline antibiotic with collagenase inhibitory activity (IC503.7*10-7M). Aranciamycin can be used to inhibit DNA synthesis in tumor cells .

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Aranciamycin

Aranciamycin Chemical Structure

CAS No. : 72389-06-1

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Aranciamycin Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Aranciamycin (Compound 1) is an anthracycline antibiotic with collagenase inhibitory activity (IC503.7*10-7M). Aranciamycin can be used to inhibit DNA synthesis in tumor cells [1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
2.7 μM
Compound: 7
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
[PMID: 38412432]
HL-60 IC50
4.1 μM
Compound: 3
Cytotoxicity against human HL60 cells after 48 hrs by WST8 assay
Cytotoxicity against human HL60 cells after 48 hrs by WST8 assay
[PMID: 20192240]
HeLa IC50
2.7 μM
Compound: 3
Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay
Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay
[PMID: 20192240]
HepG2 IC50
18 μM
Compound: 4
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25789410]
KB 3-1 IC50
> 30 μM
Compound: 4
Cytotoxicity against human KB-3-1 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25789410]
NCI-H460 IC50
> 30 μM
Compound: 4
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25789410]
PC-3 IC50
1.1 μM
Compound: 7
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
[PMID: 38412432]
SW-620 IC50
> 30 μM
Compound: 4
Cytotoxicity against human SW620 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human SW620 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25789410]
Molecular Weight

544.50

Formula

C27H28O12
CAS No.
SMILES

O=C1[C@@](C)(O)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)OC)C(C(O)=C3C(C4=C5C=CC=C4O)=O)=C1C=C3C5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aranciamycin Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aranciamycin72389-06-1Antibioticcollagenase anthracycline antibiotictumor cellsInhibitorinhibitorinhibit

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