Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26

  • J Nat Prod. 2010 Apr 23;73(4):755-8. doi: 10.1021/np9007409.
Keiichiro Motohashi  1 ,  Motoki Takagi ,  Kazuo Shin-Ya
Affiliations
  • 1. Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
PMID: 20192240 DOI: 10.1021/np9007409
Abstract

Two new anthracyclines, tetracenoquinocin (1) and 5-iminoaranciamycin (2), together with the known compounds aranciamycin (3) and Antibiotic SM 173B were isolated from the culture of Streptomyces sp. Sp080513GE-26 associated with a marine Sponge, Haliclona sp. The structures of 1 and 2 were established on the basis of extensive NMR and MS analyses along with (13)C-labeling experiments. The compounds 1-3 were evaluated for cytotoxicity against two Cancer cell lines.