Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp

  • J Nat Prod. 2015 Apr 24;78(4):949-52. doi: 10.1021/acs.jnatprod.5b00095.
Zeinab G Khalil  1 ,  Ritesh Raju  1 ,  Andrew M Piggott  1 ,  Angela A Salim  1 ,  Antje Blumenthal  1 ,  Robert J Capon  1
Affiliations
  • 1. †Institute for Molecular Bioscience, ⊥Diamantina Institute, and ∥Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
PMID: 25789410 DOI: 10.1021/acs.jnatprod.5b00095
Abstract

Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline Antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 μM) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 μM) and a panel of human Cancer cell lines (IC50 > 7.5 μM). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 μM) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-Guérin.

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